Cardiovascular System Flashcards
(20 cards)
drugs used for HTN in pregnancy
hydrazine
nifedipine
methyldopa
labetolol
calcium channel blocker used for subarachnoid hemorrhage to decrease vasospasm
nimodipine
ca blocker used fro HTN emergency and urgency
Clevidipine
Hydrazine
MOA
USE
UDE
- vasodilator arterioles more then veins. increases cGMP
- severe HTN
- Lupus like symptoms
Nitroprusside
MOA
USE
UDE
- short acting increases in cGMP and release of NO
- HTN emergency
- cyanide toxicity
Fenoldapam
MOA
USE
UDE
D1 agonist, vasodilation. decrease in BP and increases in naturesis
- post op use for antiHTN
- hypotension
drug of choice for malignant HTN
nitroprusside
Nitroglycerin, Isosorbie di/mono nitrate
MOA
USE
UDE
- vasodilator by increasing NO (dilates veins more)
- Angina and Pulmonary Edema
- Monday Diseases (loss of tolerance to the vasodilation effect over the weekend)
Ranolazine
MOA
USE
UDE
- inhibits the late phase of sodium current reducing diastolic wall tension
- angina
- QT prolongation
Statins
MOA
USE
UDE
- inhibit conversion of HMG-CoA to mevalonate. decreases LDL
- lipids
- hepatotoxic
Cholestryramine
Colestipol
Colesnvelam
MOA
USE
UDE
- prevent intestinal reasobrption of bile acid. deceases LDL
- lipid
- GI upset
Ezetimibe
MOA
USE
UDE
- prevent absortion in the small intesinte (decreases LDL)
- lipid
- diarrhes
Gemifibrozil, Bezafibrate, Fenofibrate
MOA
USE
UDE
- activate PPAR alpha to induce HDL synthesis and increases TG clearance
- lipid
- myopathy and gall stones
Niacin
MOA
USE
UDE
- inhibits lipolysis (HSL) and reduces VLDL synthesis
- lipid
- flushed, hyperglycemia, hyperuricemia
Digoxin
MOA
USE
UDE
- inhibition of sodium potassium atpase and blocks sodium calcium pump so calcium remains inside and causes contraction of the heart
- HF
- hyperkalemia
Quinidine, Procainamide and Disopyramide (class 1A)
MOA
USE
UDE
- increases action potential duration
- atrial and ventricular arrhythmia
- cinconhism, SLE like, heart failure
Lidocaine, mexilitine, Phenytoin (class 1B)
MOA
USE
UDE
- decreases action potential
- Acute ventricular arryhtmias, post MI
- cardiovascular depression
Flecainide, Propefenone (class 1c)
MOA
USE
UDE
- prolongs ERP in AV node (same AP duration)
- SVTs
- proarryhtmic
metoprolol, propranolol, esomlol, atenolol, timolol, carvediol (class 2)
MOA
USE
UDE
- decreases SA and Av nodal activity by decreasing cAMP
- SVT
- impotence
Amiodarone, Ibutilide, Dofetilide, Sotalol
MOA
USE
UDE
- increases AP duration, increases QT, increases ERP
- atrial fib, atrial flutter, vent, tacky
- torsades de pointes and Amiodarone (pum fibrosis)
