Case 1 - Mitesh Questions

Question 1

what are the 6 processes involved after a thin scar has formed in healing by secondary intention?

Answer 1

1) clot dries and forms a scab
2) scab contracts
3) granulation tissue forms and contracts
4) epidermis regenerates
5) fibrous repair of dermis
6) Scar matures

Question 2

what are myofibroblasts and their function?

Answer 2

myofibroblasts contracts and helps close the wound
they are hybrid b/w smooth muscle cells and fibroblasts

Question 3

what local factors might have been responsible for a lack of union following a bone fracture?

Answer 3

movement of a person
infection
poor blood supply
foreign bodies

Question 4

list the stages of fracture healing

Answer 4

1) haematoma formation
2) granulation tissue formation
3) soft callous formation
4) a bony callous formation (woven bone)
5) Lamellar (harder) bone
6) Bone remodelling

Question 5

describe what is meant by the term “peripheral sensitisation” as it occurs following an injury and explain the mechanisms involved

Answer 5

“peripheral sensitisation” - when afferent nociceptor (pain receptor) activity is increased

mechanisms involved:
chemicals released by tissue damage and inflammatory mediators are recruited/released to the site
these mediators activate peripheral nociceptors and decrease the threshold for activation

Question 6

what should be used for mild pain and what should be used for severe pain?

Answer 6

mild: non opioid, e.g paracetamol with anti-inflammatory

severe: morphine with anti-inflammatory