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Flashcards in case study Deck (22):
1

particles with a diameter of .... or less have POOR flow properties

50um or less

2

Good angle of repose is...

25 degrees

3

angle of repose greater than ... have poor flow

45 degrees

4

What can you add to reduce angle reduce of repose?

glidant

5

How can you measure Carr's index?

bulk density or tapped density

6

how is Carr index related to number of pores?

the lower the Carr index, the more pores, the better the flow

7

As dose increases past ...mg, compaction becomes an important factor

50mg

8

give an example of a polymorph

amorphous solids

9

the larger the Ka ...

the more soluble

10

The larger the pKa...

the less soluble

11

contact angle is related to what concept?

wettability

12

what contact angle is good?

less than 90 degrees

13

give examples of wetting agents to reduce contact angle

SLS, tween, lethicin

14

What are the 2 types of flow?

plastic and pseudo plastic

15

What polymers are used in film coating?

PVP, PEG

16

What does hygroscopicity affect?

drying, flow and ease of compaction

17

What are soft gel capsules good for?

highly potent drugs, greater than dose of 100um
using liquids/co-solvents to aid solubility

18

If powder flow is uneven, what can it lead to?

trapped air
capping and lamination
excess fine powder
dust contamination risks to handlers

19

what are the good and bad values for Carr index?

good: below 15%
bad: between 26-31%
15-26 is aight

20

What is brittle fracture?

the solid doesn't deform/isn't plastic so can lead to capping so we need to add a binder such as PVP

21

how are salts and water absorption related?

salts absorb more water than the free acid/base

22

what should solubility value be above to be 'good'?

above 10