Cases حلوة

Question 1

Necrolytic migratory erythema.

Answer 1

Gluocagonoma

Question 2

Diarrhea+Diabetes+Dermatitis

Answer 2

Gluocagonoma

Question 3

Diabetes + dermatitis + diarrhea + weight loss + pancreatic mass.

Answer 3

Gluocagonoma

Question 4

A 50-year-old man is evaluated for a 6-month history of large volume, watery diarrhea that
often awakens him at night. He has lost 20 lb in the last 6 months. He was recently diagnosed with
diabetes. He also complains of a painful, pruritic rash on his face and extremities .
He takes insulin for his diabetes but does not take any other medications. He does not smoke cigarettes, drink alcohol, or use illicit drugs. Complete blood count, serum chemistry and liver tests are normal. EGD with duodenal biopsies is normal. Colonoscopy with random biopsies is
also normal

Answer 4

What is the diagnosis?
Gluocagonoma
▶ What is this rash called?
NME
(Necrolytic migratory erythema)

Question 5

Diarrhea + Diabetes + NME rash

Answer 5

Glucagonoma

Question 6

Name of the rash found in glucagonoma.

Answer 6

NME

Question 7

Dermatitis (necrolytic migratory erythema) + Glucose intolerance + Weight loss =

Answer 7

Glucagonoma (think DDW)

Question 8

60-year-old woman presents with new-onset diabetes mellitus, anorexia, weight loss,
and diarrhea. She developed a rash 2 years prior to the onset of these symptoms. The rash
has returned intermittently since it first appeared. The rash usually begins under the folds
of her breast or buttocks, and then spreads, becomes raised, blisters, and crusts over. This
sequence occurs over a 1- to 2-week period. On exam, there is evidence of erythematous
lesions in her groin, thighs, and buttocks, along with glossitis, dystrophic nails, and angu-
lar stomatitis.

Answer 8

*What is the name of the erythematous skin lesion?
NME (Necrolytic migratory erythema)
*What is the underlying
diagnosis?
Gluocagonoma