Catabolism Flashcards
(28 cards)
phosphofructokinase
Phosphorylates Fructose-6-phosphate. Important regulatory step. Non reversible. Allosteric Enzyme
How is glycolysis regulated
High concentrations of ADT allosterically bind to phosphofructokinase,allowing the second phosphorylation event to occur.
How does the Entner Duodoroff pathway differ from EMP
The first phase of EMP pathway.
Glucose is only activated by 1 phosphorylation reaction.
Produces 6phosphogluconate which is converted to pyruvate and glyceraldehyde, which enters EMP pathway
What does ED pathway produce
1 ATP, 2 Pyruvate, and 1 NADH, and 1 NADPH
What is an important intermediate only in ED and PPS
6-phosphogluconate
Do Duodoroff pathway and PPS share an intermediate
Yes, 6-phosphogluconate
Enzyme that converts Glucose 6-P to 6-phosphogluconate
Glucose-6-phospate-1-dehydrogenase, also produces NADPH
What is unique about PPS and ED somwhat
It is an Amphibolic pathway
What is special about NADPH
It is used as a source of electrons in biosynthesis reactions
PPS imporatant intermediate
Ribulose-5-phophaste, It can be isomerized by various enzylmes. These isomers can made
Eryhtrose-4-phosphate importance
Used for aromatic amino acid biosynthesis
of carbons transferred in Transaldolase and transketolase
Transketolase transfers 2 carbons and transketolase transfers 3 carbons
TWO enzymes critical for interconversions of sugars
Transketolase and Transaldolase
Fermentation
catabolism without electron transport system and a terminal electron acceptor
Where does ATP synthesis take place in fermentaiton
The conversion of Glyceraldehye-3-phosphate to Pyruvate
Two key intermeediates for most fermentations
Pyruvate, and acetyy-CoA
Key difference between fermentatation and nonfermentative growth
Electron in NADH donates its electrons to ETC in nonfermentative but it is donated back to an organic molecule to regenrate NAD+
Other names for TCA cycle
Krebs cycle and citric acid cycle
Two major roles of TCA cycle
Oxidation of pyruvate to CO2 with production of high energy P compounds and reducing equivalents,
Important source of Carbon skeleton during biosyntheis
Describe fermentation and respiration
Fermentation is the partial breakdown of organic material without net electron transport to a final inorganic electron acceptor.
Respiration is the complete breakdown of organic material with electron transfer to a terminal electron acceptor.
Photoheterotrophy
find out what this means
Important intermediates in sugar, lipid, and amino acid catabolism/
In sugar metabolism, its pyruvate.
In lipid meatbolism, its glycerol, and acetate
Name the three pathways of catabolism
Embden-meyerhoff parnas pathway
Entner-duodoroff pathway
Pentose Phosphate Shunt
Important components of Pyruvate dehydrogenase complex
NAD->NADH, Pyruvate loses a carbon
