Categories

Question 1

Alkylating Agents

Answer 1

Nitrogen Mustards
Methylhydrazine derivative
Alkyl sulfonate
nitrosoureas
Triazenes
Platinum coordination complexes

Question 2

Nitrogen Mustards

Answer 2

Cyclophosphamid
ifosfamide
mechlorethamine
melphalan
chlorambucil

Question 3

Methylhydrazine derivative

Answer 3

procarbazine

Question 4

Alkyl Sulfonate

Answer 4

busulfan

Question 5

Ntrosoureas

Answer 5

carmustine
streptozocin
bendamustine

Question 6

Triazines

Answer 6

dacarbazine

temozolomide

Question 7

Platinum Coordination complexes

Answer 7

cisplatin
carboplatin
oxaliplatin

Question 8

Antimetabolites

Answer 8

Folic acid analogs
pyrimidine analogs
purine analogs

Question 9

Folic acid analogs

Answer 9

methotrexate

pemetrexed

Question 10

Pyrimidine analogs

Answer 10

Flourouracil
capecitabine
cytarabine
gemcitabine
5-aza-cytidine
deoxy-5-aza-cytidine

Question 11

Purine analogs

Answer 11

mercaptopurine
pentostatin
fludarabine
clofarabine
nelarabine

Question 12

Natural products

Answer 12

vinca alkaloids
taxanes
epipodophyllotoxins
camptothecins
antibiotics
echinocandins
anthracenedione
enzymes

Question 13

vinca alkaloids

Answer 13

vinblastine
vinorelbine
vincristine

Question 14

taxanes

Answer 14

paclitaxel

docetaxel

Question 15

epipodophyllotoxins

Answer 15

etoposide

teniposide

Question 16

camptothecins

Answer 16

topotecan

irinotecan

Question 17

antibiotics

Answer 17

doxorubicin
dactinomycin
daunorubicin

Question 18

echinocandins

Answer 18

yondelis

Question 19

anthracenedione

Answer 19

bleomycin
mitoxantrone
mitomycin C

Question 20

Enzymes

Answer 20

l-asparaginase

pegaspargase

Question 21

Hormones and antagonists

Answer 21

steroid hormones

progestins, antiestrogens, antiandrogens

Question 22

Monoclonal Antibodies

Answer 22

Rituximab
alemtuzumab
gemtuzumab
trastuzumab
cetuximab
bevacizumab
ibritumomab
tositumomab

Question 23

Vaccines

Answer 23

Hep B vaccine

Gardasil (HPV vaccine)

Question 24

Agents to min adverse effects

Answer 24

Sargramostim
filgrastim and pegfilgrastin
oprelvekin
EPO/darbepoetin
serotonin antagonists (ondansetron)

Question 25

Misc agents

Answer 25

``` substituted urea differentiating agents biological response modifiers immunomodulators protein TK inhbitors proteasome inhibitor mTOR inhibitors ```

Question 26

mTOR inhibitors

Answer 26

temsirolimus | everolimus

Question 27

proteasome inhibitor

Answer 27

bortezomib

Question 28

substituted urea

Answer 28

hydroxyurea

Question 29

differentiating agents

Answer 29

tretinoin arsenic trioxide histone deacetylase inhibitor

Question 30

biological response modifiers

Answer 30

interferon-alfa | interleukin-2

Question 31

immunomodulators

Answer 31

thalidomide | lenalidomide

Question 32

Protein TK inhib

Answer 32

``` imatinib dasatinib nilotinib gefitinib erlotinib sorafenib sunitinib lapatinib ```

Question 33

Alkylating MOA

Answer 33

electrophiles-form covalent linkages with DNA cross-linkng (prevents tumor from unwiding DNA for mRNA prod) miscoding tru abn base pairing with T or excision of G (strand breakage) CCNS

Question 34

Alkylating SE

Answer 34

acute-N/V 30-60 min of IV, tissue damage at injection site delayed-BM dep (leukopenia, thrombocytopen) nephrotoxicity alopecia mucosal ulceration intestinal denudation Inc risk of 2 malig (AML)

Question 35

Alkylating SE (cyclophosphamide)

Answer 35

hemorrhagic cystitis-accumulation acreolin | IV mesna to prevent

Question 36

Alkylating SE (cisplatin)

Answer 36

renal tubular damage-hydration ototoxicity-worse in kids, UL BL NV

Question 37

Alkylating SE (busulfan)

Answer 37

hyperpigmentation, pulmonary fibrosis, adrenal insuff

Question 38

Antimetabolites MOA (foli acid analogs)

Answer 38

inhib dihydrofolate reductase, blocks conversion of folic acid to tetrahydrofolic acid CCS (s-phase) can give leucovorin to allow thymidine synthesis to proceed (sparing severe GI, BM tox)

Question 39

Antimetabolites SE (folic acid)

Answer 39

mucositis, diarrhea, myelosuppresso with neutropenia/thrombocytopenia, N/V immunosuppression, hepatotox, fatigue

Question 40

Antimetab MOA (pyrimidine, Fluorouracil)

Answer 40

prodrug, FdUMP covalently binds thymidylate synthetase blocks synth of thymidylate interferes with DNA synth/fx, RNA processing, mRNA translation CCS (s-phase)

Question 41

Antimetab SE/USE (pyrimidine, 5-FU)

Answer 41

mostly used in colorectal cancer | anorexia, N/D, stomatitis