CAW Basics

Question 1

3 types of mesh

Answer 1

Synthetic, Biologics, Bioresorbable

Question 2

Biological Mesh Response in Body

Answer 2

Cells penetrate implant pores
Enzymatic Degradation
Angiogenesis
Cells and collagen proliferate
Natural tissue completely replaces graph

Question 3

Wound Healing Race

Answer 3

Winning: wound heals before graft remodels

Not winning: graft degrades before wound heals

Question 4

Why wouldn’t a surgeon want to use a synthetic graft?

Answer 4

Infection or contamination, synthetic mesh is permanent

Question 5

Why use a biologic?

Answer 5

Graft goes away, less foreign body response

Question 6

What is XenMatrix mesh madeout of

Answer 6

non-cross linked porcine dermis

Question 7

XenMatrix’s open _______ strucure allows for early remodeling

Answer 7

collagen

Question 8

Two antibiotics on Xenmatrix AB

Answer 8

Rifampin and Monocylin

Question 9

Which two bacteria is XenMatrix known to protect against?

Answer 9

MRSA and E.Coli

Question 10

How long does XenMatrix antibacterial coating last?

Answer 10

7-14 days

Question 11

Polymer that binds antibacterial coating to Xenmatrix?

Answer 11

Tyrosine

Question 12

Rifampin

Answer 12

kills bacteria

Question 13

Minocyclin

Answer 13

stops replication of bacteria

Question 14

Zone of Inhibition

Answer 14

We have a larger zone of inhibition than our competitors

Zone of inhibition is where the mesh is capable of inhibiting bacteria colonization

Question 15

Repair strength of XenMatrix AB is ____ times stronger than the natural abdominal wall

Answer 15

3

Question 16

Heniford Study General Tkae away

Answer 16

Came out that XenMatrix was the most expensive and we had the highest rate of infection

Question 17

XenMatrix AB detectable drug concentration

Answer 17

will not result in detectable systemic concentrations of Rifampin or Minocycline

Question 18

What is the likelihood of antibiotic resistance with XenMatrix AB?

Answer 18

clinical studies have shown that it is unlikely that a bacterial strain will become resistant to both drugs at the same time

Question 19

What is Phasix made of

Answer 19

poly 4 hydroxybutyrate

Question 20

How does Phasix degrade?

Answer 20

hydrolysis

Question 21

How long does it take for Phasix to be resorbed?

Answer 21

12-18 months

Question 22

What happens when Phasix comes in contact with bacteria?

Answer 22

Nothing. Phasix is broken down by hydrolysis

Question 23

Phasix mesh has an open _____ structure that allows for _____ and ______

Answer 23

monofilament

early tissue ingrowth and vascularization

Question 24

XenMatrix ____ kills bacteria and Phasix _____ kills bacteria

Answer 24

actively

passively

Question 25

Matthews study for Phsaix

Answer 25

as mesh strength decreases over time, new healthy abdominal wall strength increases

Question 26

Phasix ST difference from Phasix

Answer 26

has the sepra technology which works as barrier for intraabdominal placement

Question 27

What is Sepra Technology made of

Answer 27

PEG HA CMC

Question 28

Phasix ST can be placed in which two planes?

Answer 28

intrabdominal or preperitoneal

Question 29

Phasix ST comes in home many sizes?

Answer 29

12

Question 30

How long does it take for the hydrogel barrier to resorb?

Answer 30

30 days

Question 31

How does the Sepra Technology stay on the mesh?

Answer 31

PGA fibers weave the ST into the mesh