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CBC and the Peripheral Smear Flashcards

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1
Q

What does MCH stand for?

A

Mean Corpuscular Hemoglobin

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1
Q

What is another name for Burr cells?

A

Echinocytes

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2
Q

When do schistocytes appear?

A

Microangiopathic hemolytic anemia (HUS, TTP, DIC), burns, HELLP, mechanical heart valves

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3
Q

What does MCHC stand for?

A

Mean Corpuscular Hgb Conc.

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3
Q

What does a Dohle Body look like?

A

a pale blue incision at the periphery of the cytoplasm of a neutrophil

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4
Q

How will the RBCs appear in hereditary spherocytosis?

A

as spherocytes

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5
Q

What is another name for Spur cells?

A

Acanthocytes

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5
Q

What does Babesiosis look like?

A

very intense round dots with vacuoles inside and outside the RBCs

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6
Q

How is MCHC calculated?

A

= HGB/HCT × 100

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6
Q

RBCs that are small, spherical, and w/o central pallor are called?

A

spherocytes

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6
Q

Describe Target cells.

A

central hemoglobin gives target shape

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7
Q

What is another name for Echinocytes?

A

Burr cells

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7
Q

What causes Pappenheimer bodies?

A

iron overload, postsplenectomy, asplenia

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8
Q

What are Cold Agglutinins?

A

RBC clumping b/c of cold temperature

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9
Q

What do Henz bodies look like?

A

blue spots in pale cells- Denatured/oxidized hemoglobin attached to the inner cell membrane

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10
Q

How is DIFF # calculated?

A

= (DIFF% × WBC)/100

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10
Q

When are spherocytes seen?

A

immune hemolytic anemia

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12
Q

What does DIFF% stand for?

A

NE%, IG%, LY%, MO%, EO%

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13
Q

What does RET% stand for?

A

Reticulocyte Percentage

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13
Q

Why are the RBCs in hereditary elliptocytosis longer than they are wide?

A

a defective spectrin α chain

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13
Q

What causes ovalocytes?

A

vitamin B12 or folate deficiency

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13
Q

What is another name for Acanthocytes?

A

Spur cells

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15
Q

How is MCH calculated?

A

= HGB/RBC × 10

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16
Q

When are sickle cells seen?

A

in Hb SS

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17
When would Howell-Jolly bodies be seen?
post-splenectomy, asplenia, megaloblastic anemia, myelodysplasia
19
What does WBC stand for?
White Blood Cell count
20
What do sickle cells look like?
banana shaped
21
What are bite cells?
RBCs with a bite-like defect or hemighost cell
22
How does Plasmodium falciparum appear?
as small rings or double chromatin dots w/i the RBCs; banana-shape gametocytes
24
What does RET# stand for?
Absolute Reticulocyte Number
25
What does RBC stand for?
Red Blood Cell count
25
How do teardrop cells look?
they are teardrop or pear shaped with a single elongated tail
26
How is MCV calculated?
= HCT/RBC × 10
27
Hereditary spherocytosis is associated with the \_\_\_\_.
ankyrin mutation
29
How do cells appear in hereditary elliptocytosis?
length 2x the width
30
What does HPC stand for?
Heme Progenitor Cells
31
What are spherocytes?
RBCs that are small, spherical, and w/o central pallor
32
What does MCV stand for?
Mean Corpuscular Volume
33
What is Basophilic stippling?
evenly dispursed fine blue granules of aggregated ribosomes and rRNA
34
When are stomatocytes seen?
Alcohol, dilantin, Rh null, or hereditary stomatocytosis
35
A spectrin α chain defect leads to \_\_\_\_\_.
hereditary elliptocytosis
37
What does DIFF # stand for?
Absolute Count NE#, IG#, LY#, MO#, EO#, BA#
38
When would Henz bodies appear?
with G6PD
39
What is a Howell-Jolly body?
RBC with a single, dense blue dot of nuclear DNA remains
41
What does MPV stand for?
Mean Platelet Volume
42
How will the RBCs appear in immune hemolytic anemia?
as spherocytes
42
When do Dohle Bodies appear?
infection, inflammation, burns, or pregnancy
43
How is RET# calculated?
= (RET% × RBC)/100
44
\_\_\_\_\_\_ is associated with the ankyrin mutation.
Hereditary spherocytosis
45
What does MCH stand for?
Mean Corpuscular Hemoglobin
46
When would Echinocytes be seen?
acute renal failure or pyruvate kinase deficiency
48
What do stomatocytes look like?
elongated, central pallor, mouth-like
49
What does HGB stand for?
Hemoglobin Concentration
51
What causes bite cells?
the spleen removes the Heinz body- G6PD
52
Why does neutrophil Toxic Granulation (Hypergranularity) occur?
Due to rapid cell division (not enough time to dilute)
53
Henz bodies are commonly seen with \_\_\_\_\_.
bite cells
55
Ovalocytes are seen in \_\_\_\_\_\_\_\_\_\_.
megaloblastic anemia
56
What does MCV stand for?
Mean Corpuscular Volume
57
What does PLT stand for?
Platelet Count
58
What is a Rouleaux formation?
loss of RBC repulsion and negative charge, causing adhesions of cells like a stack of coins
60
What does NRBC stand for?
Nucleated RBC count
62
G6PD is associated with _____ cells.
bite
62
When are Acanthocytes seen?
liver disease, Abetalipoproteinemia, McLeod phenotype
63
Describe Echinocytes.
Many sharp projections, even distribution, central pallor
64
Describe Acanthocytes.
few blunt projections, irregular distribution, no central pallor
66
What causes Basophilic stippling?
lead poisoning, porphyria, infections
67
How should normal RBCs look on a peripheral smear?
circular, uniform in size (6-8um), central pallor
68
What is a Pappenheimer body?
RBC with multiple blue dots of iron
69
\_\_\_\_\_\_ are seen in megaloblastic anemia.
Ovalocytes
70
When does neutrophil Toxic Granulation (Hypergranularity) occur?
Bacterial infection, Marrow recovery ,Stimulation G(M)- CSF
71
What is a schistocyte?
a fragmented RBC- "helmet cell"
72
What are ovalocytes?
large, ovoid RBCs
73
When would Target cells be seen?
Thalassemia, hemoglobin C, iron deficiency, liver disease
74
On a peripheral smear, what is the RBC appearance in iron deficiency anemia?
small with larger central pale area (microcytic and hypochromatic)
75
What does HCT stand for?
Hematocrit

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