CCD vs AD Poster

Question 1

What is tau protein?

Answer 1

stabilizes neuronal microtubules under normal physiological conditions

Question 2

what is hyperphosphorylated protein?

Answer 2

occurs when a biochemical with multiple phosphorylation sites is fully saturated

Question 3

why is hyperphosphorylated protein bad

Answer 3

causes tau to lose its original microtubule stabilization activity - neuronal damage

Question 4

what is microglia?

Answer 4

primary immune cells of the central nervous system

Question 5

What is an astrocyte?

Answer 5

subtype of glial cells that make up the majority of cells in the human central nervous system (CNS)

Question 6

What are glial?

Answer 6

Any of the cells that hold nerve cells in place and help them work the way they should

Question 7

what is a neurofibrillary tangle

Answer 7

abnormal accumulations of a protein called tau that collect inside neurons.

Question 8

why are neurofibrillary tangles bad

Answer 8

block the neuron’s transport system, which harms the synaptic communication between neurons

Question 9

What is rostral?

Answer 9

towards head

Question 10

What is caudal?

Answer 10

towards tail

Question 11

What is Immunohistochemistry?

Answer 11

lab technique that uses antibodies to detect antigens in a tissue sample

Question 12

What is an antigen?

Answer 12

Any substance that causes the body to make an immune response against that substance.

Question 13

What is IBa1?

Answer 13

Ionized calcium binding adaptor molecule 1, pan-microglial marker whose expression increases with microglial activation

Question 14

What does increased microglia mean?

Answer 14

overactive microglia can contribute to the death of healthy neurons, which may cause the disease to progress more rapidly

Question 15

S100B

Answer 15

S-100 calcium-binding protein,

Question 16

T231

Answer 16

Detects Tau when phosphorylated

Question 17

Bete-amyloid

Answer 17

necessary for hippocampal synaptic plasticity and memory, abnormal levels clump together to form plaques that disrupt cell function

Question 18

what is synaptic function

Answer 18

transmit nerve impulses between two nerve cells (neurons) or between a neuron and muscle cell

Question 19

CCD symtoms

Answer 19

doesn’t recognize familiar people, gets confused, turns away from petting, diffrent tail wagging, barks for no reason at night, stops greeting you, messes in the house

Question 20

canine cognitive dyfunction patients average age

Answer 20

8-9

Question 21

AD symtoms?

Answer 21

memory loss, language difficulties, and challenges in performing daily activities

Question 22

what enrichment changes can help with ccd

Answer 22

exercise, new and interactive toys, and learning new tasks

Question 23

Why the hippocampus?

Answer 23

involved in memory, learning, and emotion.