CCFP Flashcards

(408 cards)

1
Q

Secondary causes of HTN ABCDES

A

Atherosclerotic, coarctation of the aorta
Bad kidneys - Renal parenchymal disease
Catecholamines
Drug, Diet
Endrocrine (Hypothyroid, aldosterone, Cushing), EtOH
Fibromuscular dysplasia
sleep apnea, stress

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2
Q

Medications that raise BP

A

Steroids, NSAIDs, amphetamines, many psychiatric meds - SSRIs, SNRIs, carbamazepine, estrogen/progesterone/androgens, sympathomimetic (decongestant), licorice

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3
Q

What does a lipid panel include

A

Chol, HDL, LDL, non-HDL, TG

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4
Q

Risks of HCTZ?

A

Skin cancer non melanoma, possible 4x risk after 3 years

Avoid long acting Chlorthalidone, indapamine b/c of DM2, renal and electrolyte abnormalities

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5
Q

Lifestyle interventions for HTN

A

Lower salt, exercise, weight loss, reduce alcohol, DASH diet, relaxation –> CBT

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6
Q

HTN Meds to avoid in HTN

A

alpha blocker alone
Beta blockers if > 60
ACE if black

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7
Q

Risk factors for uterine perforation

A
breast feeding
grand multiparity
history of csection
nulliparity
inexperienced HCP
uterine abnormalities 
postpartum state in breastfeeding women
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8
Q

when should you start various kinds of birth control when removing an IUD?

A

POP 2 days before, ocp/depo etc 7 days before

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9
Q

contraindications to IUD

A

pelvic TB, pregnancy, uterine/cervical malignancy, puerperal sepsis, post-septic abortion, unexplained vaginal bleeding, gestational throphoblastic disease with persistently elevated betahcg (decreasing beta is relative), distorted uterine cavity, current PID/gonochlam

mirena: breast cancer, hx of ischemic heart disease, antiphospholipid antibodies, migraine with aura, severe cirrhosis
copper: severe thrombocytopenia

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10
Q

What does SAD PERSONS stand for

A
Male sex
Age <19, >45
Depression
Previous attempt
Excess EtOH/substances
Loss of rational thinking
Social supports lackings
organized plan
no spouse
Sickness
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11
Q

What else should you r/o with depression

A

mania, anxiety (does worry get in the way of your life?), OCD (thoughts/rituals you cannot stop), delusions (special powers/plot against you), hallucinations

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12
Q

when to consider bipolar?

A
age <25
>= 5 episodes
family hx
hypersomnia
hyperphagia/increased weight
lability of mood/irritability
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13
Q

first line meds/treatments for PTSD

A

fluoxetine, paroxetine, sertraline
venlafaxine
CBT
group therapy

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14
Q

first line meds/treatments for OCD

A

escitalopram, fluoxetine, paroxetine, sertraline
CBT
exposure with response prevention

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15
Q

mimics for depression

A

hypothyroid, adrenal insufficiency, grief/adjustment disorder, drug use, bipolar, tumor, delirium

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16
Q

SPIKES

A
setting up
perception
invitation
knowledge
emotion
strategy, also SAFETY.
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17
Q

SNOPQRST

A
Safety
Next visit
Offer
Prevention
Quit 
Refer
Start
Teach
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18
Q

Osteoporosis risk factors

A
Age > 65
Sex - female
post menopausal
Alcohol 
Chronic disease i.e. RA
Chronic steroid use
Previous fragility fracture
Malabsorption/eating disorder
Hypogonadism
low body weight <60kg
for <50yo, fragility #, prolonged use of CS, high risk meds, hypogonadism/premature menopause, malabsorption syndrome, primary hyperparathyroidism, other d/o associated with rapid bone loss and/or fracture
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19
Q

Chronic bronchitis criteria

A

Chronic bronchitis is defined as a cough with sputum expectoration for at least 3 consecutive months for at least
2 consecutive years

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20
Q

Thalassemia regions

A
Southeast Asia
Africa
South America
Middle East
Carribbean 
Mediterranean
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21
Q

Broad differential? VINDICATE

A
Vascular
Infectious
Neoplasm
Drugs
Idiopathic
Congenital
Autoimmune
Trauma
Endocrine
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22
Q

COPDE

A

cough, purulence, dyspnea, CRP >40

Early warning score i.e. NEWS2

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23
Q

Common ear bugs? what about (complicated) COPD? what about PNA?

A

Hemophilus influenza
Moraxella catarrhalis
Strep pneumonia
(same as for COPD; if complicated add on klebsiella, gram negatives, pseudomonas; same for pneumonia, if comorbid add on staph aureus, if not comorbid, atypicals - mycoplasma and chlamydophila)

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24
Q

COPD Adjunctive Treatment

A
Flu/pneumonia shots
Action plan to reduce hospital use
CPAP?
Daily macrolide (azithro, erythro) to decrease exacerbations
Exercise
Quit smoking
Pulmonary rehab
Puffers - SABA, LAMA, 
Respiratory therapy
Teach inhaler technique
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25
SNOPQRST
``` Safety Next visit Offer Prevent Quit Refer Start Teach ```
26
Criteria for dx asthma in <6 yo
Wheeze that reverses | it's not something else
27
What are the criteria for asthma dx
FEV1/FVC pre <0.75 FEV1 post increases 12% vs. COPD; post <0.70 and not reversible
28
Asthma rx pyramid for pre-schoolers
mild - saba mod - saba + ICS severe - saba, ICS, oral steroids
29
Asthma rx pyramid for 6+
mild - LABA + ICS (symbicort) as needed mod - saba + daily ICS OR as-needed ICS/LABA- formeterol (LTRA as alternative) mod + - low dose ICS/LABA plus as needed SABA, OR low dose ICS/LABA plus as needed ICS/LABA mod ++ - med dose ICS/LABA plus as needed SABA, OR low dose ICS/LABA plus as needed ICS/LABA next! refer for phenotypic investigations + add-on treatment severe - saba, ICS, LABA, LAMA, LTA, theophylline **if uncontrolled, saba +/- ICS/LABA on demand
30
Good asthma control
<1 night time symptoms <4 use of prn puffer no activity restrictions, no missed school/work
31
Risk factors for asthma exacerbations
ICS not prescribed, poor adherence, GERD, obesity, previous ICU/intubation for asthma, irritants - smoking/allergen/pollution, allergic rhinitis, food allergy, depression, anxiety, pregnancy, FEV1<60% NSAIDs, betablockers
32
Frequency of asthma f/up? in pregnancy?
1-3 months after starting treatment then 3-12 months after that; in pregnancy, every 4-6 weeks
33
Testicular cancer BALLS CFP
Bhcg Alpha fetoprotein Lop it off Cryptorchidism Family hx Personal hx
34
Lung cancer screening
age 55-74, 30pk/yr smoke, current or quit <15 years ago. CT annually up to 3 times
35
Cervical cancer screening
``` 25-69 every 3 years unless - never sexually active - weakened immune system - symptoms of cervical ca - previous abnormal results - those who do not have a cervix - immunosuppressed CAN stop at age 70 if 3 normal in last 10 years ```
36
Skin cancer risk factors
``` Nevi > 15 older white skin, red hair hx of skin cancer, sun exposure family history multiple sunburns actinic skin damage --> refer if hi risk, skin checks q6 months ```
37
skin cancer ABCDE
Asymmetry Border - gradual, indistinct vs. sharp cut off Colour variation Different dermatoscopic structures - pigment network, homogeneous areas, streaks, dots, globules Evolving size/shape/colour
38
Colorectal screening
50-74 | flex sig q10 or FIT q2 years
39
Breast Ca screening (5)
``` 1. Screen with mammography every 2-3 y if aged 50-74 y 2. Do not routinely screen those aged 40-49 y 3. Do not screen with magnetic resonance imaging 4. Do not perform clinical breast examination 5. Advise patients not to perform self breast examination ```
40
Management for Feb neut?
early antibiotic treatment, look for source and consider fungal stabilize and assess severe sepsis --> ICU
41
H Pylori quad therapy
PPI Bismuth salicylate Metronidazole Tetracycline
42
what is Barrett's esophagus? prevention,
columnar cells replace squamous; | prevention - high dose PPI and ASA
43
long term risks of PPIs
fractures b12 deficiency dementia c diff
44
gallstone RF
female forty fat fertile -- on OCP
45
pancreatitis RF
``` septra, flagyl HCTZ, ACE progesterone atorva estrogen gall stones ETOH ``` I = idiopathic (also known as the fancy medical way of saying, “I dunno.”) G = gallstones (one of the two most common causes of acute pancreatitis) E = EtOH (the other common cause of acute pancreatitis) T = trauma S = steroids M = mumps/malignancy A = autoimmune S = scorpion stings … though this probably shouldn’t be your first guess for why your patient has pancreatitis H = hypertriglyceridemia/hypercalcemia E = (post) ERCP D = drugs. Most commonly: thiazides, sulfa drugs, and didanosine
46
admission criteria - UN
uncontrolled symptoms unstable undiagnosed pain esp in elderly, immunocompromised undischargable i.e. poor social support
47
fluid for peds
``` 20 mg/kg maintenance 4/2/1 - 4 ml/kg for the first 10kg - 2ml/kg for 11-20 - 1 ml/kg 20+ ```
48
measures to monitor for severe dehydration
``` weight gfr/creatinine na, k glucose urea ```
49
c diff risks
``` abx esp fluoroquinolones previous infxn recent hospitalization older age immunocompromised ```
50
c diff pitfalls, who not to test? and rx
not just hospital acquired don't test kids <1 rx: vanco po
51
Crohn's medications
start with sulfasalazine if mild, otherwise steroids thiopurines - not for induction methotrexate biologics
52
celiac testing
TTG/IGA plus total IGA +/- upper endoscopy, small intestine biopsy OR endomysial IGA (but this is +++expensive) if IGa deficiency, DGP IgA and IgG
53
IBS rx
``` r/o celiac psyllium probiotics, peppermint oil FODMAP CBT colonoscopy if >50/alarm features antispasmodics anti depressants eluxadoline - diarrhea predominant lubiprostone - constipation predominant linaclotide - " ```
54
Restless legs rx, rx and non rx
``` non rx iron, mg stretch calves avoid caffeine massage, heat exercise rx non ergot dopamine agonists - pramipexole, ropinirole alpha-2-delta calcium channel ligand - gabapentin, pregabalin ```
55
restless legs dx
sensation or urge to move legs worse with rest, improves with activity worse in evening
56
restless legs risk factors
▪ Highly heritable – often family history (↑young age onset) ▪ Pregnancy ▪ Low ferritin (can be with or without anemia) ▪ Medication induced –Caffeine, Alcohol, Antihistamines, Dopamine agonists, Antidepressants, Lithium ▪ Associated diseases –ADHD, Parkinsons disease, Anxiety, Depression, Anemia with iron deficiency, Obesity, Diabetes, Renal disease
57
Dx hyperthyroid
Radioactive iodine uptake (NOT for ladies who are preggers), unless 100% sure it's graves B block for symptoms nodule? >1cm = FNA don't treat subclinical hyperthyroid
58
suspicious features of thyroid nodule
>1cm Taller than wide irregular surface calcifications within
59
Treating thyroid storm - BLOCK x 5
Beta blocker - propanalol Block synthesis - methimazole, propylthiouracil Block conversion T4 --> T3 propylthiouracil Block release - iodine Block Bile - cholestyramine
60
Treating graves, 3 Rs
Rx - First 4 Blocks - beta blocker, block synthesis, block conversion, block release Radiation Removal
61
Meds to stop when sick/at risk of dehydration | SADMANS
``` SFU ACE Diuretics Metformin ARBs NSAIDs SGLT2 ```
62
Three reasons people develop DKA
- acute illness, - drugs: clozapine, terbutaline, cocaine, lithium, SGLT2 - non compliance
63
Diabetes complications, micro/macro
micro - retinopathy, neuropathy, nephropathy | macro - atherosclerosis --> CVD, CVA, PVD
64
Biguanide
metformin
65
SGLT2 inhibitors
flozins - empagliflozin, canagliflozin
66
GLP-1R agonists
glutide - semaglutide, liraglutide
67
DPP4 inhibitors
saxagliptin
68
sulfonylureas
gliclazide, glyburide
69
driving 2-4-6 rule
test BS every 2 hours - if hypoglycemia unawareness test BS every 4 hours - treat and wait 40 min keep 6 lifesaver candies in the car for lows
70
risk factors for hep B
``` IVDU sex with partner with hep B child born to mother with hep B tattoos blood transfusions living in crowded conditions unimmunized multiple sexual partners MSM occupation prison hx of STIs breastfeeding OK if skin is in intact ```
71
medications to treat chronic gout
allopurinol prboenecid febuxostat
72
how to test for Hep C?
anti - HCV (unless known previous hep C) HCV RNA serum genotype and subtype --> spontaneous clearance in 20-45%
73
how to test for Hep b?
``` HbsAg Anti HBS Anti HBC --> IgM, total if +ve HBeAg HBV DNA Anti HBe ```
74
Mgmt and monitoring hep B
``` Refer to hepatology Anti virals if severe, cirrhosis U/S q6-12 months for HCC scope every 1-3 years for varices Cirrhosis/fibrosis - fibroscan, Child Pugh ``` The current approved treatments for HBV are interferon injections (standard or pegylated interferon) or oral nucleoside/nucleotide analogues (entecavir, lamivudine, tenofovir). As oral antivirals are excreted by the kidney, dose adjustments are required in renal failure. Not all patients with chronic HBV infection need to be treated. The decision to treat depends on several factors including age, serial ALT and HBV DNA levels, and severity of liver disease. Co-infection, particularly with HIV and HCV, needs to be considered when deciding on which medications to use. HBsAg (surface antigen) indicates infection. Persistence of HBsAg for 6 months or more indicates chronic infection. However, up to 50% of people with extended chronic infection will eventually clear HBsAg. By contrast, those with resolving acute HBV will clear HBsAg several months after initial infection. Anti-HBs (surface antibody) is a protective antibody produced with recovery from infection or in response to immunization. Over time, titre may decline to undetectable levels. Note: There is a gap of several weeks to months between the disappearance of HBsAg and the appearance of anti-HBs; during this period, anti-HBc total is detectable as a marker of HBV infection. Anti-HBc IgM (core antibody - IgM) appears early in acute HBV infection and persists for about 6 months. It may also be seen in chronic infection during flares of activity, so clinical/epidemiological correlation is required for interpretation. Anti-HBc total (total core antibody - IgM and IgG) is a marker of past exposure or current infection. IgG usually persists for life. In low prevalence populations, a finding of isolated anti-HBc may signify a false positive result. HBeAg (e-antigen) is a marker of viral replication; its presence indicates high infectivity. Implications for liver injury vary with stage of infection (see Module 7 for significance). Anti-HBe (e-antibody) appears with recovery from acute infection. In chronic infection, the presence of anti-HBe is generally a marker of reduced viral replication, indicating a less infectious state. The implications for liver injury vary with stage of infection (see Module 7 for significance)
75
Mgmt and monitoring hep C
``` Refer to hepatology Treat: interferon or new regimens U/S q6-12 months for HCC scope every 1-3 years for varices Cirrhosis/fibrosis - fibroscan, Child Pugh ```
76
NAFL vs NASH, and treatment?
NASH = NAFL + hepatitis (increased ALT/AST) = signs of inflammation NAFL - no inflammation or fibrosis = STEATOSIS Rx - stop EtOh, weight loss, lipid control, DM control, if fibrosis >2 consider vitamin E
77
Ankylosing Spondylitis features
low back/SI pain stiffness worse w/ rest, improves w/ movement worse at night 30 minutes + for morning stiffness to recede weight loss, fatigue chest pain -- from insertion into sternum enthesis i.e. plantar fasciitis, achilles tendonitis anemia uveitis aortitis heart block
78
what is Schober's test
find L5, measure 10cm above and 5cm below = 15cm | if <20cm when bending forward = restrictive
79
investigations for Ankylosing Spondylitis
ESR, CRP HLA b27 spine xray or MRI for early changes
80
mgmt AS
``` nsaids steroids for flares - oral, IM, into joint anti TNF monoclonal antibody physio no smoking bisphosphonates if osteoporosis ```
81
Back pain physical exam
ALWAYS: numbness, weakness, pedal pulses, neuro exam
82
Lower limb Myotomes memory aid
L1/L2 buckle my shoe - hip flexion L3/L4 kick the door - knee extension C5/6 pick up sticks - biceps C7/8 - shut the gates
83
Dermatomes memory aid
L4 down on all 4s - knees to first toe L5 middle toes S1 pinky toe
84
joint red flags
``` hot boggy AM stiffness PM night pain extra-articular symptoms? think genital infection, vasculitis, systemic illness ```
85
ADHD medication classes
Stimulants - methylphenidate (concerta, biphentin, ritalin), amphetamine (vyvanse, adderall) SNRI - Atomoxetine Alpha receptor antagonist - Guanfacine
86
ADHD meds -- Consider DATER before changing medication to 2nd/3rd line
Dosage All - trial of all 1st line Time - enough time given for response/side effects to resolve Examine - what are the targets? what standardized measures Review - comorbidity, lifestyle
87
ADHD non rx management
patient and family education psychological treatment education accommodations driving -- restrict cell phone use, recommend manual transmission
88
ODD vs conduct disorder
ODD children do not show aggressions towards peope/animals; destroy property; pattern of theft and deceit
89
Bedwetting management
``` make toilet accessible pee before bed including in morning cleanup training pants avoid fluids/caffeine/chocolate before bed do not punish, introduced diapers enuresis alarms desmopressin for short-term ```
90
Well baby care counselling HONEY 'n' guns
``` No honey Choking hazards Vitamin D Breast/fed is best button battery ingestion No guns Carbon monoxide detector Cover electric plugs Hot water heater car seats Storage and poison control ```
91
Milestones
``` 2 months - two = coo, smiles 4 months - hold object - four fingers and hold head, laughs 6 - sit at six with support 8 - pincer grasp 1 year - walk, 1 word; responds to name 15 months- stranger danger 2 - run, 2 word sentence, 1-2 step directions 3 - 3 step instructions 5 - adult like sentences ```
92
Breastfeeding guideline
>=2 years | 400IU daily vitamin D
93
circumcision, pros and cons
pros - decreased infection - phimosis (rx with topical steroids), uti, hpv, cancer cons - pain, stenosis, damage to surrounding tissues
94
undescended testes cause
``` torsion trauma tumor inguinal hernia infertility ```
95
torsion TWIST score
``` absent cremasteric reflex nausea/vomiting testicle swelling testicle hard high riding testicle ```
96
4 nots for nuts
refer if - not descended at 6 months - not there anymore - not there - not positioned properly
97
AIDS defining illnesses
``` Kaposi’s sarcoma Pneumocystis jirovecii pneumonia (PCP) Cytomegalovirus Candidiasis (oesophageal or bronchial) Lymphomas (excluding Hodgkins) Tuberculosis ```
98
when to give Tdap to pregnant ladies
>13, ideally 27-32 weeks
99
which vaccines can you NOT give if someone is breastfeeding?
BCG, yellow fever, japanese encephalitis
100
which vaccines do you need to delay if someone is ill?
lots of congestion -- don't give nasal flu acute GI -- defer cholera, dukoral mod to severe -- defer rotavirus
101
who gets flu vaccine?
kids > 6 months everyone, but esp adults with neurologic/developmental conditions, work in health care, work with poultry > 65 yo
102
vaccines in person with egg allergy
flu, MMR ok | do not give yellow fever, tick-borne encephalitis or rabies
103
make vaccine less painful?
``` breastfeed skin to skin most painful last sugar tylenol after, otherwise blunts immune response topical anesthetic don't aspirate ```
104
what are the two shingles vaccines? | what kind, how often, how $$$, how effective?
zostavax = live attenuated 1 dose, $170, >60 yo shingrix = non live recombivant, adjuvanted 2 doses, 2(-6) months apart 2x as effective, 2x as much >50yo
105
HPV vaccine - # of doses, #-valent
2 doses, 9-valent, all genders
106
who do you give meningitis C to? (5)
``` all travellers to Hajj meningitis belt of africa military recruits asplenia and sickle cell all canada adolescents ```
107
vaccines for the immunocompromised? keep 3 things in mind
- no polio, varicella, MMR - close contacts: avoid giving or avoid contact for 2 weeks - consult public health/ID
108
vaccines contra-indicated in... | pregnancy? TB? severe asthma/medical wheeze in last 7 days? uncorrected GI malformation? HIV?
pregnancy: live vaccines (polio, varicella, MMR), BCG --> flu ok active TB: MMR, varicella, herpes zoster, BCG asthma: live attenuated influenza GI malformation: rotavirus (risk of intussception) HIV: all live vaccines
109
Common cold treatment? (5)
NSAIDs, honey (> 1 year), intranasal ipratropium, nasal decongestant/anti-histamine (>5 year), zinc (not intranasal)
110
sinusitis risk factors? (4) which bugs?
``` allergic rhinitis asthma anatomy smoking ear bugs ```
111
red flags on sinusitis? (9)
``` fever > 39 periorbital edema cranial nerve palsies abnormal EOM proptosis vision changes severe headache altered mental status meningeal signs ```
112
what are the meningeal tests?
Brudzinski - flexed neck --> flexed extremities | Kernig - with hips flexed cannot extend knee
113
PODS acute sinusitis
``` pressure/pain obstruction (nasal) dischage - thick, purulent smell, loss of 2 or more -- persists for >7-10 days ```
114
mgmt of acute sinusitis
``` ct/xr only if red flags amox 500 TID 5-10 days nasal steroids! nasal rinse decongestants analgesics anti-inflammatories mucolytics ```
115
why give abx for GAS? what does it NOT prevent?
``` prevent... AOM rheumatic heart disease sinusitis decrease illness <1 day peritonsillar abscess does NOT prevent glomerulonephritis ```
116
mono - how does it spread? symptoms? labs? recommendations re: spleen?
saliva lymphadenopathy, fatigue, sore throat, splenomegaly, headache lymphocyte count, serume AST/ALT, monospot NO abx no contact sports min. 3 weeks, can last up to 8 weeks
117
Jaundice beyond two weeks, order:
``` hemoglobin serum conjugated bili coomb's test group and screen peripheral smear ```
118
Symptoms of down syndrome - rule of 1s
1st toe web space 1 palmar crease 1% recurrence
119
Hip dysplasia risks, ffff
``` first born feet -- breech family history fluid -- oligo female ```
120
full septic workup in kids
CBC LP CXR urine/blood cx
121
pediatric LIMPSS cannot miss
``` Legg calves perthe Infectious Malignancy - ewing's sarcoma, osteosarcoma Pain from a fracture - abuse? Slipped capital femoral epiphysis Something else above/below ```
122
Classes and examples of constipation meds
Stool softeners – docusate (colace) Osmotic laxatives – lactulose, Mg salts, sorbitol, PEG Bowel stimulants (motility agents) – senna, bisacodyl, cascara, prune juice Bulking agents – psyllium, bran (Metamucil ok) Bowel lubricants – mineral oil, castor oil, glycerine Enemas – tap water, saline, sodium phosphate (fleet), oil
123
Counselling pts for HCV - 4
Discussion of avoidance of alcohol Monitoring of progression (ALT/AST, annual AFP) Counsel on risk of transmission Screening sexual partners
124
HCV treatments
``` Pegylated Interferon Ribavirin Telaprevir Simeprevir Sofosbrevir Harvoni (ledipasvir/sofosbuvir) Holkira Pak (dasabuvir, ombitasvir, paritaprevir, ritonavir) velpatasvir daclatasvir ```
125
Mechanism of scaphoid #
Extreme dorsiflexion of the wrist with compressive force to the radial side of the palm Fall on outstretched hand/arm Forceful radial deviation and dorsiflexion of wrist Direct axial compression or hyperextension of the wrist
126
Physical exam for snuffbox tenderness
Anatomic snuffbox tenderness Scaphoid tubercle tenderness (extend the patient’s wrist with one hand and apply pressure to the tuberosity at the proximal wrist crease with the opposite hand) Positive results on the scaphoid compression test (axially/longitudinally compressing a patient’s thumb along the line of the first metacarpal) Swelling on the dorsoradial side of wrist or over the anatomical snuffbox Pain in the snuffbox with pronation of the wrist followed by ulnar deviation Reproduction of pain when patient pinches tips of their thumb and index finger together
127
Scapholunate disruption on xray
A gap of more than 3 mm between the scaphoid and lunate bones (the Terry Thomas sign)
128
Scaphoid #, reasons to refer to ortho
``` open fractures neurovascular compromise displacement of 1 mm or more angulated fractures associated tilt of the lunate bone associated carpal instability evidence of nonunion or displacement during follow up osteonecrosis possible scapholunate dissociation proximal pole fractures oblique fractures unwillingness or inability of the patient to wear a cast for up to 3 months ```
129
Why does scaphoid have higher rates of fracture complications?
The scaphoid bone has a tenuous blood supply running from distal to proximal. RATIONALE: The blood supply comes from the radial artery, feeding the bone on the dorsal surface near the tubercle and scaphoid waist with no direct blood supply to the proximal portion. Thus, there is an increased possibility of nonunion or osteonecrosis with fractures, particularly those of the proximal pole.
130
Symptoms of hypercalcemia
``` mental status change confusion poor concentration abdominal groans (e.g. abdominal pain) nausea vomiting anorexia fatigue/lethargy renal colic dehydration polyuria polydipsia constipation bone pain muscle weakness anxiety depression ```
131
Rx for hypercalcemia
Hydration with normal saline Calcitonin Bisphosphonates
132
Medications that cause hypercalcemia
``` ationale: Thiazide diuretics (class or specific drug name of any thiazide acceptable) Lithium Teriparatide Abaloparatide Theophylline Excessive vitamin A Excessive vitamin D ```
133
1st blood test to order with dx of hypercalcemia
PTH
134
Risk factors for neonatal jaundice
Prematurity Vacuum delivery leading to cephalohematoma Asian background Possible dehydration (poor weight gain)
135
Blood tests in neonatal jaundice
``` Blood type (ABO and Rh status) of infant Direct antiglobulin test (direct Coomb’s test) ```
136
Inherited disorder that cause hyperbilirubinemia
Glucose-6-Phosphate Dehydrogenase Deficiency Pyruvate Kinase deficiency Crigler-Najjar syndrome Hereditary spherocytosis or elliptocytosis Hemoglobinopathies (sickle cell, thalassemia, Hemoglobin H disease)
137
Side effects from phototherapy?
Dehydration Bronze baby syndrome / bronze discolouration of the skin skin rash over or under heating of infant / temperature instability loose stools/diarrhea electrolyte disturbance (hyponatremia or hypokalemia) interference with maternal –infant interactions Ocular damage
138
Causes of hyperbilirubinemia in babies <24 hrs
hemolytic disease of the newborn (Rh or ABO incompatibility, spherocytosis, G-6PD deficiency, Kell Congential hemolytic states) Maternal autoimmune hemolytic anemia (e.g. lupus) Type 1 – usually by day 3 Concealed hemorrhage/hematoma Vitamin K deficiency
139
Treatment for ABRS
amox, nasal steroids
140
Classic sites for infantile eczema
Cheeks Face Scalp Extensor surfaces (elbows and knees would count as 2 answers) 1/2 point for Flexor surfaces (flexor surfaces can be found in any age, however, extensor surface involvement is more classic for infantile eczema) Trunk
141
Risk factors for infantile eczema
``` Positive family history of atopy (give ½ point for either “allergy” or “asthma”) Weather changes (cold, dry) Chemical irritants (scented soaps, detergents) ```
142
strategies to prevent/treat eczema
``` Reducing frequency of baths Unscented products (soap, detergents) Minimize soaps Emollients Barrier creams Use luke warm water for baths Avoiding triggers or irritants Exclusive breastfeeding (although some small studies are refuting this) Parental education Topical steroids Antibiotics in severe cases ```
143
when to treat asymptomatic BV?
Pregnant women with history of a high-risk pregnancy (previous preterm delivery) Prior to IUD insertion Second trimester even if asymptomatic (check this) Prior to gynecologic surgery/therapeutic abortion/genitourinary instrumentation Immunocompromised patient
144
abx to treat trich? what else can be used for BV?
metronidazole | clinda, doxy
145
Pediatric Limps LIMPSS
``` Leg Calve Perthes Syndrome - boys, age 4-10, white Infection/inflammation Malignancy - Ewing's Sarcoma (small round blue cells - pelvis, thigh, lower leg, upper arm, and rib), Osteosarcoma (Osteosarcoma usually develops at the edges of the long bones, in the “metaphysis” esp. the knee) Pain from a fracture - abuse? Slipped Capital Femoral Epiphysis - obese, adolescent, black/latino Something above or below? ```
146
HEADSS
``` Home environment - smokers, smoke alarms Education - bullying Activities - helmets Drugs - prescription drugs Sexuality/sex Suicide ```
147
Kawasaki's CRASH
``` Conjunctivitis Rash Adenopathy Strawberry tongue Hands and feet swollen/rash/peeling if you CRASH call the CAA --> coronary artery aneurysm treat with ASA and IVIG kawASAkI ```
148
Violent/aggressive patient? Think of other causes | DIM FACES
Drugs/dehydration Infection Metabolic/medication change ``` Failure Anemia/alcohol Cardiac/stroke/bleed Electrolytes Structural/seizure disorder/psychiatric ```
149
Which vaccines should you consider for travel?
General - Hep A and B, rabies Country specific - typhoid, meningitis, yellow fever, encephalitis routine - flu, shingrix, pneumococcal, tetanus, pertussis
150
Anti malarial medications and their pros/cons?
Malarone - only for 7 days after exposure daily, expensive Doxy - cheap but photosensitivity rash. daily dose, need for 30 days after exposure Mefloquine - frequent side effects, vivid dreams. once weekly primaquine - only for 7 days after exposure; daily dose need test for G6Pd chloroquine - cheap, safe, widespread resistance so check first, skin and corneal side effects
151
Rx for traveller's diarrhea and how to prevent
``` Azithro oral rehydration solution loperamide bismuth subsalicylate boil, peel; avoid ice cubes, salads, uncooked veggies use bottle water, wash hands often ```
152
medications for altitude sickness?
``` acetazolamide - carbonic anhydrase inhibitor dexamethasone nifedipine sildenafil/tadalafil prophylactic salmeterol ```
153
AAA screening
men 65-80 one time ultrasound
154
calculate sensitivity specificity ppv npv
``` sens = true pos / true pos + fals neg spec = true neg / true neg + fals pos ppv = true pos / true pos + false pos npv = true neg / false neg + true neg ```
155
DM screening
1. Screen every 1-5 y depending on risk determined using a calculator, other risk factors, or age ≥40 y 2. HbA1c level is the preferred screening test (FPG level or OGTT are acceptable alternatives) 3. HbA1c level of ≥6.5%, FPG level of ≥7 mmol/L, or 2-h plasma glucose level in an OGTT of ≥11.1 mmol/L are diagnostic
156
DLP screening
1. Screen fasting lipid profile in men aged ≥40 y, women aged ≥50 y (or postmenopausal), or earlier if at increased risk 2. Screen with Framingham risk assessment every 3-5 y if 10-y risk is <5%, or every y if 10-y risk is ≥5%, until age 75 y 3. Framingham risk should be doubled if positive family history for premature cardiovascular disease 4. Discuss “cardiovascular age”
157
Colon Ca screening
1. Screen with FIT or FOBT every 1-2 y, or flexible sigmoidoscopy every 10 y, if aged 50-75 y 2. Consider individualized opportunistic screening with FIT or FOBT, flexible sigmoidoscopy, or colonoscopy up to age 85 y
158
HPV recommendations
``` 1. Recommended for women up to age 45 y even if already sexually active and regardless of past infection 2. Recommended for men up to age 26 y 3. Recommended for men who have sex with men ```
159
Immigrant health, four areas - infection
HIV, Hep C, TB | mantoux skin test is intradermal
160
TB rx, RIPE
Rifampin Isoniazid Pyrazinamide Ethambutol
161
Common parasitic infections? Ss
strongyloides | Schistosomiasis
162
Unconscious patient? DONT
dextrose oxygen Narcan Thiamine
163
Rx for new psychosis?
``` start med 1st gen = 2nd gen maintain for 18 months oral = depo if depression, treat that too. ```
164
neuroleptic malignant syndrome FARM and treatment (5) and meds (3)
Fever Autonomic - BP, HR, sweating Rigidity Mental status changes stop the rx; IV NS; cooling blankets; ice packs; DVT prophylaxis benzos if agitation; bromocriptine; dantrolene for muscle relaxation
165
qSOFA
resp rate >22 aMS SBP < 100
166
STI abx
cefixime + azithro or doxy OR | ceftriaxone + doxy if PID
167
sinusitis abx
amox or amox-clav
168
bronchitis abx
none
169
diverticulitis abx
none if CT confirmed with no abscess/free air | cipro + flagyl or amox clav
170
sepsis abx
ceftriaxone or pip tazo +/- vanco
171
yeast vaginitis rx
fluconazole oral
172
pneumonia abx
macrolide or fluoroquinolone
173
meningitis bugs and abx
TB, LEGS - listeria, e coli, GBS, meningococcus = neisseria meningitis < 1mo - amp + gent Group B Streptococci E. coli Listeria spp ``` 1-3 mo amp + cefotaxime Group B Streptococci E. coli Listeria spp S. pneumoniae N. meningitidis H. influenzae ``` ``` > 3 months cef + vanco S. pneumoniae N. meningitidis H. influenzae ``` ``` Adult > 50 years or Immunocompromised (including AIDS), Alcohol abuse, Debilitating illness, Pregnancy cef + amp + vanco S. pneumoniae Listeria monocytogenes N. meningitidis Enterobacterales ``` REMEMBER... contact public health! contact prophylaxis! vaccinate!
174
cellulitis abx? MRSA?
with pus = ?mrsa = doxy, septra, clinda | w/o = strep = amox clav, cephalexin
175
uti abx? what if complicated? severely ill? peds?
nitrofurantoin, septra, cephalexin, fosfomycin if complicated... fluoroquinolone, 3rd gen cephalosporins, broad spectrum, of severely ill i.e. pip-tazo, ertapenem peds - cefixime 7-10 days and image if febrile <2 yrs, recurrent or complicated (sepsis, obstruction, retention, impacted stone, pyelo)
176
pyelo abx
ceftriaxone | then cefixime or septra or cipro or amox-clav
177
remember your TOCC hx
travel occupation contacts critters
178
4 strategies to minimize statin effects on muscles
lower dose rink lots of fluids stop interacting medications alternative day dosing
179
rx for molluscum contagiosum
cantharidin topical
180
Describe arterial ulcer
Punched out full thickness ulcer with smooth wound edges often on lateral ankle or distal digits
181
Describe karposi sarcoma
Red-purple lesions/patches/nodules
182
Describe scabies
intensely pruritic and pimple like rash at the wrists and Intertriginous areas
183
describe herpes labialis
small grouped blisters/sores on lips that can coalesce into an ulcer that heals with 2-3 weeks
184
describe hand foot and mouth
lesions on oral mucosa, tongue, palms, soles and buttocks, grey-white vesiculo pustules
185
describe venous ulcers? risk factors?
shallow and superficial ulcers with irregular margins usually on the lower leg and ankle rf: obesity, immobility, pregnancy, DVT, CHF, varicose veins, conditions with poor musculature
186
describe herpes zoster
grouped, unilateral vessicles in dermatomal distribution +/- pain and prodromal symptoms. anti virals with in 48-72 hours --> do not confuse with eczema herpeticum
187
indications for shingrix vaccine
over 50 years, diabetes, heart disease, renal disease, immunosuppresion
188
describe BCC, treatment options
shiny, pearly nodule located on sun exposed area of skin with telangectasia rx: excision, cryotherapy, topical chemo
189
describe roseola infantum
high fever then rash on chest that turns into a pink maculopapular eruption lasting 1-2 days. 6th disease, HHV 6/7, supportive care
190
describe erythema infectiosum
macular erythema on face on day 1, then erythematous maculopapular eruption for up to 7 days on proximal extremities, then a reticulated or lacy erythema on extensor extremities up to 3 weeks. parvovirus/5th disease
191
Dx of HTN, work-up
AOBP > 135/85 or non-AOBP >140/90 Lipid panel (HDL, LDL, chol, trig, non-HDL) Na, K, Creat, urinalysis, HbA1C, EKG CPAP does not decrease morbidity/mortaliity
192
Recommendations for HTN lifestyle
``` reduce salt - diet - DASH <1800mg reduce weight reduce stress - CBT increase exercise 30-45 min, 3x/week reduce alcohol <2.7 drinks/day ```
193
Fever? keep the ddx broad (11) and don't forget the most dangerous things
``` sepsis meningitis steven's johnston syndrome PE GCA medication cancer/feb neut serotonin syndrome neurleptic malignant syndrome endocarditis rheum -- still's disease unclear? back to basics, serial exams/ekgs/imaging ```
194
DLP screening. When should it be fasting?
>40 and <75 consider earlier in at risk groups: South/East asians and First Nations, gestational HTN Fasting if TG > 4.5 no evidence of mortality benefit of statins if >75
195
DLP management - who to start on statin? | what other things can you do?
Statin based on Framingham > 10 OR if CHD, CAD, PAD, AAA, DM2, CKD Optimize renal, HTN, and CVD rx dietician (med diet), counselling, stop smoking, kinesiology, cardiology, endocrinology (if familial)
196
Vertigo Exam (4)
Orthostatic BP Gait Hints Dix-Hallpike
197
Vertigo ddx
``` BPPV orthostatic meniere's migraine neuritis stroke ```
198
HINTS exam
Pt looks at nose; head impulse to one size continues looking at you = normal (central vertigo) corrective saccades = abnormal (peripheral vertigo)
199
Acute situatuation - ABC MOVIES and cereal
``` monitors oxygen vitals IV large bore x 2 ECG sugars serial ekgABCs/vitals ```
200
GI Bleed rx
PPI infusion Erythromycin prior to scope because it increases GI motility Hgb only if <70 IF varices, give ceftriazone + octeotride (somatostatin)
201
what's the reversal agent for... warfarin? heparin? dabigatran?
vit K protamine, fresh frozen plasma praxbind
202
what are the drug classes for anxiety?
``` benzodiazepines buspirone selective serotonin reuptake inhibitors selective norepinephrine reuptake inhibitors tricyclic antidepressants monoamine oxidase inhibitor atypical anti-psychotics ```
203
after SIGECAPS, r/o other conditions by asking about
- excessive worry, panic, PTSD - hallucinations? - rituals/compulsions that you cannot stop? - mania -- feel better than good? - delusions - do you have special powers? is there a plot against you?
204
Bipolar II, criteria and dx | Bipolar meds
- hypomania, no psychosis quetiapine is first line Acute: abilify, paliperiodone, risperidone Maintenance: quetiapine, lamotrigine, lithium, divalproe
205
1st gen antipsychotics - D2 antagonism, higher risk of neurological side effects
haldol | chlorpromazine
206
2nd gen antipsychotics "atypicals" 5HT2A/D2 antagonism | higher risk of metabolic side effects
``` abilify olanzapine paliperidone quetiapine risperidone clozapine ```
207
Tourette syndrome rx
Tetrabenazine or Risperidone (dopamine blockers) Botox - neuromuscular blocade Habit reversal training
208
PICA rx
methylphenidate - CNS stimulant olanzapine Treat the complications -- radiography for a bezoar
209
Scabies rx
permethrin, invermectin
210
Mastitis rx
continue BF NSAIDs, abx (cloxacillin, cephalexin) usually staph warm/cold compresses
211
Melanoma dx
``` Asymmetry Border irregularity Color not uniform Diameter > 6mm Evolving shape/size/colour ```
212
Measles description, symptoms
purplish red, maculopapular rash starting on the scalp/face/neck and spreading downwards Four Cs: cough, coryza, photophobia, conjunctivitis, koplik spots on buccal mucosa
213
describe Alopecia areata? what conditions is it associated with? what is the treatment?
circular lesion on scalp/body with no hair, may have characteristic exclamation mark hairs. Focal, non scarring ddx: trichotillomania associated with SLE, thyroid, family hx <50% hair loss - steroids either topically or injected, minoxidil >50% hair loss - oral steroids 8 week taper while minoxidil while awaiting referral
214
Marjolin ulcer
non healing ulcer or growth on the edge of a chronic wound - type of SCC
215
Pityrasis rosea
single lesion followed by all over body rash. Oval, dull pink colour involving the trunk and upper arms and legs. Christmas tree distribution
216
Head lice rx
permethrin or pyrethrin, repeat in 7-10 days
217
Rx for androgenic alopecia
stop offending meds minoxidil finasteride hair transplant
218
Rosacea
superficial, dilated blood vessels and papules/pustules/swelling on the face
219
stevens-johnson syndrome
``` painful red or purplish rash involving the skin and mucous membranes stop med/avoid drug class in future ```
220
Koebner's phenomenon
formation of psoriasis in areas of trauma
221
Rx for post herpetic neuralgia
``` topical capsaicin NSAIDs gabapentin TCAs glucocorticoids paracetamol topical lidocaine ```
222
investigations to order for dx osteoporsis (7)
``` hgb TSH ionized Ca Alk Phos Creatinine SPEP if vertebral # Vit D --> after 3 months of Vit D supplementation ```
223
Osteoporosis rx - 3 options + 2 for high risk | When can you stop it?
Bisphosphonates - jaw osteonecrosis - esophageal ulcers - atypical fractures Raloxifene --> selective estrogen receptor modulator - VTE/PE HRT for high risk Teriparatide - PTH analogy - hypercalciuria, hypercalcemia - usually transient - angioedema Denosumab - monoclonal ab vs. RANKL - joint muscle pain - jaw osteo - CI in pregnancy Stop after 3-5 years if low risk take holiday
224
HIV med complications
DLP hyperglycemia BMD loss Renal disease
225
HIV meds to know
Truvada for PREP Zidovudine - peripartum and neonate PEP - truvada, raltegravir
226
Opioid guidelines
maxmimum 50mg MED start taper down to 90mg MED if they are above that only use if no other options - TCAs, nabilone, NSAIDs, CBT, exercise, physio
227
ADL - DEATH
``` Dressing Eating Ambulating Toileting Hygiene ```
228
IADLS - SHAFT
``` Shopping Housework Accounting Food and meds Telephone, transportation ```
229
Frail elderly checklist
``` vision hearing skin - ulcers mobility cognition pain medications rx monitoring abuse driving incontinence falls teeth ```
230
Post phlebitic syndrom
horse chestnut seed extract for venoconstriction
231
DVT w/up and treatment
if low Pre test prob/Wells < 2 -- D-dimer. if +ve, proximal leg compression ultrasound or CTPA if you suspect PE if high Pre test prob/Wells >2 -- ultrasound. if -ve, d dimer if suspicion is high and testing will be delayed, treat first! 1 dose of oral Xa inhibitor or 1 dose of LMWH/IV heparin
232
Bell's palsy, dx and treatment
Stroke spares forehead lubricant eye drops steroids eg prednisone add antivirals if severe
233
Ramsay Hunt Triad
aka Herpes Zoster reactivation - ipsilateral facial paralysis - ear pain - vesicles in the auditory canal
234
Ischemic vs hemorrhagic findings
ischemic 80% - early, focal | Hemorrhagic 20% - late focal deficits, compression effects (headache, vomiting)
235
Acute stroke management
1. ABCs, MOVIEs 2. Stroke scale 3. Labs: Na, K, Hgb, INR, aPTT, creatinine, troponin, glucose 4. Head CT non contrast --> if 4.5-6 hours adter symptoms add CT angiogram from vertex to arch OR CT perfusion. If 6-24 hours after symptoms add CT angiogram AND CT perfusion 5. Treat fever and severe hypertension >220/120
236
Acute stroke treatment options
1. Bust clot - alteplase, tenecteplase - treatment within 3-4.5 hours, >18 yo 2. Yank clot 6-24 hrs- endovascular thrombectomy, aspiration/vacuum/removal stent - acute ischemic stroke, anterior circulation, large vessel
237
Stroke w/up (cause - 4)
- Holter monitor - Carotid doppler/duplex ultrasound - manage A fib if found - ECHO
238
Stroke prevention ABCDEs
``` A Fib BP CVD DM2 Ethanol ```
239
cephalosporins
1st gen - cephalexin (keflex) PO, cefazolin (ancef) IM/IV 2nd gen - cefuroxime IM/IV 3rd gen - cefixime PO, ceftriaxone IV no activity against LAME = listeria, atypicals, MRSA, enterococci Good against gram +ves, increasing gram -ves as you progress at expense of gram +
240
Macule
flat lesion less than 1 cm, without elevation or depression
241
Patch
flat lesion greater than 1 cm, without elevation or depression
242
Plaque
flat, elevated lesion, usually greater than 1 cm
243
Papule
elevated, solid lesion less than 1 cm
244
Nodule
elevated, solid lesion greater than 1 cm
245
Vesicle
elevated, fluid-filled lesion, usually less than 1 cm
246
Pustule
elevated, pus-filled lesion, usually less than 1 cm
247
3 indications for using cannabinoids ? which product for which indications?
Muscle spasm 2/2 SCI, MS - nabiximol Neuropathic pain refractory to standard therapies- nabilone or nabiximol N/V from chemo - nabilone
248
4-6-8 rule for driving after cannabinoid
don't drive less than 4 hours less than 6 hours for oral ingestions and less than 8 if you experience euphoria
249
managing opioid withdrawal
treat type of pain - neuropathic vs other clonidine if BP >150/90, HR >50; for nausea/vomiting/sweating/tremor diarrhea - start loperamide, stop stool softeners abdo cramping - buscopan (hyoscine), pinaverium muscle cramping - quinine sweating - oxybutynin (anti-cholinergic)
250
what are the domains for major neurocognitive disorder? 5 W's
WHO you are, WHAT you say, WHERE you go, WHY you do things, WHEN you remember ``` learning and memory complex attention executive function language, perceptual motor social cognition Alzheimer's is any one PLUS memory affected mild = 1 domain major = 2 or more plus impair function/decline ```
251
how to assess competency?
explain your treatment options? WHAT reasoning? WHY choice? WHAT ELSE
252
investigations for MNCI d/o?
TSH Hgb/ferritin B12 Na, Ca, glucose | Do a CT Head if last done less than 2 years ago/looking for something else
253
Management for MNCI
- cholinesterase inhibitors --> donepezil - glutamatergic --> memantine exercise cognitive stimulation avoid antipsychotics
254
Parkinson's symptoms TRAP SSSS
``` Tremor Rigidity Akinesia Postural instability Shaky Stiff Slow Steps ```
255
DDx for Parkinson's
tremor improves with EtOH? better at rest? --> Essential tremor On an antipsychotic? - extrapyrimidal side effects falls, slow vertical gaze - progressive supranuclear palsy no L-dopa improvement, symmetric - Multi-systems atrophy
256
Parkinson treatment, things to avoid (5), treat other features
first line - carbidopa/levidopa 30% don't respond, 20% who do have another dx second line - 1. Dopamine agonists, non ergot - pramipexole, warn about impulse control d/o i.e. gambling, binge eating avoid ergot derived i.e. bromocriptine 2. MAO inhibitors - selegiline, rasagiline Avoid... anti psychotics (except quetiapine, clozapine); abruptly stopping meds; amantadine early on; genetic testing/PET scanning; vit E/coenzyme q10 Also look for/treat: constipation, drooling, ED, hypotension
257
Rx for postural hypotension
quit - large meals, EtOH, warmth, medications start - compression stockings, increase salt intake, bed tilt, elastic stockings, midodrine (alpha 1 agonist) or corticosteroid
258
headache -- serious causes to r/o
``` GCA SAH Stroke meningitis Tumour ```
259
red flags for headache SNOOP
``` systemic features neuro symptoms older pt/onset other red flags pattern change ```
260
ottawa SAH tool r/o tool must meet criteria (4), C/I (5) Rule: if any of the following 6...
``` alert patients >15 years old new severe atraumatic headache maximum intensity in 1 hr do NOT USE if: neuro deficits, prior aneurysm, prior SAH, known brain tumour, chronic recurrent headache require investigations if: 1. neck pain or stiffness 2. => 40 yo 3. witnessed LOC 4. peak during exertion 5. thunderclap headache -- immediate peak intensity 6. limited neck flexion on exam ```
261
Migraine Rx - acute, chronic, lifestyle management
Migraine medications: A) Acute migraine medications. B) Prophylactic migraine medications. A) Type ACUTE MEdications First line Ibuprofen 400 mg, ASA 1000 mg, naproxen sodium 500-550 mg, acetaminophen 1000 mg Second line Triptans (oral wafer/nasal spray/IM) Antiemetics: domperidone 10 mg or metoclopramide 10 mg for nausea Third line Naproxen sodium 500-550 mg in combination with a triptan Fourth line Fixed-dose combination analgesics (with codeine if necessary; not recommended for routine use) also consider -- sphenopalatine ganglion block B) Prophylactic Medications First line • propranolol/metoprolol - avoid in asthma • ami/nottriptyline - Consider if patient has depression, anxiety, insomnia, or tension-type headache ``` Second line • topiramate • candesartan • gabapentin Few drug interactions Botox for chronic ``` Lifestyle management: - decrease caffeine, improve sleep, increase exercise, relaxation, CBT
262
ABCs of fractures
``` Antibiotics? Analgesia Brace/splint Consult ortho? Compartment syndrome? Stick them with Tetanus -- Tetanus immunoglobulin if dirty wound/not vaccinated or immunocompromised ```
263
Fractures of abuse (8)
``` multiple multiple, many healing non ambulatory femur <12-18 months humerus <18 months skull metaphyseal - bucket handle rib posterior ```
264
Salter-Harris
``` Slipped Type I Above Type II Lower Type III Through or transverse Type IV Rammed Type V ```
265
causes of Afib (6)
``` ischemic valvular alcohol hyperthyroid HTN pulmonary - COPD, pulmonary embolism ```
266
Afib rx, anticoagulate?
convert IF unstable, symptomatic/poor QOL, cardiomyopathy otherwise bblockers or ccb if unstable/low clot risk -- anticoagulate now and cardiovert now if hi clot risk, OAC for 3 weeks or TEE rate control if old, longstanding, asymptomatic, other disease rhythm control if young, new dx, symptomatic, no other disease
267
CHADS2
``` CHF HTN Age >65 DM2 Stroke/TIA/embolism ```
268
Bleed risk management HAS BLED
HTN SBP>160 Abnormal liver/kidney fxn Stroke Bleeding Labile INR Elderly >65 Drugs/EtOH
269
Which anticoagulant for -- CKD? pregnancy? cancer? valvular afib?
UFH - renal disease CKD LMWH - pregnant, cancer Warfarin.- valvular
270
Systemic Exertional Intolerance
``` Functional impairment > 6 months Non exertional new fatigue Post exertion malaise Rest does not refresh At least 1 of cognitive impairment or orthostatic intolerance ```
271
Panic attack symptoms
``` Students Fear CCCs Sweating Trembling Unsteadiness Dyspnea Excessive sweating Nervousness Tachycardia/tachypnea Sensation weird Fear of death Choking Chills Chest pain ```
272
Lupus | MD SOAP BRAIN
Mallar rash Discoid Rash Serositis - pericarditis, pleuritis Oral ulcers ANA +ve Photosensitivity Blood - thrombocytopenia, hemolytic anemia Renal - GN Arthritis Immune - anti phospholipid, anti dsDNA, anti rho, C3/C4, anti smith Neurological disorders, including psychiatric disorders - psychosis, seizures
273
Symptoms/presentation of Thyroid Storm?
``` Altered mental status Tachy Fever Dyspnea/orthopnea Chest pain Hypertension Profuse sweating ```
274
IBD systemic features APIESAC
``` Apthous ulcers Primary sclerosis cholangitis, pyoderma gangrenous Iritis/uveitis Erythema nodosum Sacroilitis Arthritis Clubbing ```
275
Pro-thrombotic states
``` Protein c and s deficiency - like renal disease because you lose protein Nephrotic syndrome Hormonal meds Pregnancy Cancer IBD, CHF Factor V leiden Anti phospholipid syndrome ```
276
Upper Arm DVT
CONSTANS score — upper arm DVT 1 point each, -1 if other dx more likely Unilateral pain Edema Hx of central line/pacemaker placement “trauma”
277
Risk factors for AOM
maternal smoking pacifiers day care bottle feeding
278
Ear bugs? 5
``` strep pneumo moraxella catarrhalis hemophilus influenza staph aureus group a strep ```
279
rx for AOM? if failure?
amoxicillin - high is BID, low if TID 40-90mg/kg if failure? clavulin or ceftriaxone tylenol 10mg/kg advil 15 mg/kg
280
what are the indications for ear ventilation tubes? (3)
``` >6/yr or 4 per 6 months or Chronic OM with effusion, "glue ear" > 3 months with hearing loss or retracted TM ```
281
CATCH2 for pediatric head injury, AVPU?
Minor head injury and any one of the following GCS <15 (can also use AVPU for younger children --> Awake - Verbal - Responds to Pain - Unresponsive) worsening headache Suspected open/depressed skull fracture irritability Sign of basal skull fracture Large, boggy scalp hematoma Dangerous mechanism >4 episodes of vomiting (common pain response in kiddos)
282
types of SHOCK
``` septic hypovolemic obstructive cardiac AnaphylacticK ```
283
Burns - formulas? special sites?
>10% resuscitate - Brooke formula: 2mls x body surface areas burned (BSAB) x weight Rule of 9s adult - legs 18% x 2, arms 9% x 2, head 9%, chest 18%/back 18%, groin 1% infant - legs 14% x 2, arms 9% x 2, head 18%, chest 18%/back 18%, groin 1% special sites: face, hand, foot, genital, perineum, joint
284
Frostbite rx - 5 steps
``` rapid rewarming - water bath possible thombolysis and heparin and iloprost sterile wound care consult surgery tetanus ```
285
MAPLE hx
``` medications allergies past medical history last meal events leading up to ```
286
GCS
4 - eye response; 4 spontaneous - 3 sound - 2 pressure 5 - verbal; 5 oriented - 4 confused - 3 words - 2 sounds 6 - motor; 6 obeys - 5 localizes pain - 4 withdraws from pain 3 - flexion to pain 2 - extension to pain 1 - no movement
287
ATLS updates
give blood early! after 1L crystalloids smaller chest tubes 28-32 french needle decompression 4th/5th intercostal space laterally use massive transfusion protocols tranexamic acid 1g for 10 min and 1g for 8 hours e-fast for pneumothorax
288
Trauma in pregnancy
``` Mom then fetus Chest tube 1-2 spaces higher NG tube Left lateral decubitus No vag exam until previa ruled out Anti D immune globulin if Rh negative Tetanus vaccine is safe Document domestic violence ```
289
Treatments for acute seizure in adult? pregant? pediatric? 1st and 2nd line.
Adult - 1st benzo 2nd phenytoin, valproate Pregnant - 1st Mag Sulf 2nd benzo Peds - 1st benzo 2nd phenytoin, phenobarb
290
Reversible causes of LOC
``` Hyperopioidemia Seizure Hypovolemia HyperCa Hyperthermia Hypoglycemia Hypoxia Hyponatremia ```
291
Red eye red flags (5)
``` Pain Decrease visual acuity Aniscoria Photophobia Metal work ```
292
Clinical ft of acute angle closure glaucoma (5), physical exam (6), and treatment?
``` Headache N/v Halos around lights Eye pain Decreased vision ``` Physical Exam: Visual acuity, Evaluation of the pupils, Intraocular pressure (IOP), Slit-lamp examination of the anterior segments, Visual field testing, Undilated fundus examination Rx: - pressure lowering eye drops - IV acetazolamide repeat eye pressures 30-60 minutes after meds administration
293
What to do before prescribing eye steroids?
measure eye pressure!
294
Management for premature rupture?
steroids and antibiotics
295
Management for preterm labour?
fetal fibronectin steroids tocolysis magnesium sulfate <32 weeks
296
active labour? labour dystocia? abnormal FHR?
active = >4 cm dilation dystocia = <2cm in 4 hours abnormal fhr = <110 or >160
297
post partum Bs (11)
``` breasts bottom belly baby breast feeding bowels bladder bleeding blues birth control boinking ```
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Approach to medical abortion
- confirm GA - exclude ectopic - assess for CI: uncontrolled asthma, chronic adrenal failure, chronic corticosteroid use, hematologic disorders - remove IUD Ordering lab tests: bHCG if using for monitoring completion GC/CT testing Rh status Hgb if reason to suspect anemia Advise of risks. Surgical evacuation may be required in the event of retained products of conception or heavy bleeding (5%) or ongoing pregnancy (<1%). Heavy bleeding requiring transfusion is rare (0.1%). Infection is rare (1%) and severe infection/sepsis extremely rare (.01%).
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Management for STEMI
CODE STATUS! - PCI < 120 minutes - Morphine - only if severe pain, increases mortality in NSTEMI - O2 only if O2 <90% otherwise increases free radicals - Nitrates -- use for analgesia, no mortality benefit - ASA - 27% mortality benefit - B blocker - antiplatelet therapy - ACE - statin 80
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DDx for chest pain
lung - pneumothorax, PE, infection, blood heart - valves, endocarditis, pericarditis/Dressler's syndrome (post MI) esophagus - inflammation, acid, spasm, foreign body, rupture, tear aorta - dissection, aneurysm, infection chest wall - costochondritis, muscle, contusion, fracture, zoster psychiatric abdomen
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Management for PE
Do WELLS first; if low risk, do PERC to rule out. YEARS for pregnant women
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Rx for HFrEF
``` mineralocorticoid receptor antagonist i.e. spironolactone ACE beta blocker lasix + SGLT2 inhibitor even if no DM2 ```
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Breast Cancer risk factors
``` Estrogen exposure Early menarche Late menopause Nulliparity Postmenopausal HRT, obesity Radiation exposure Alcohol Sedentary lifestyle ``` Non modifiable Age > 50 sex past hx, family hx
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Red flags in breast lump and when to monitor (4 each(
Peau d'orange Firm fixed lymph nodes Inverted nipple Risk factors Monitor if: smooth, rubbery, mobile, cyclic
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BMI formula and ranges
``` kg/m^2 <18.5 underweight 18.5-25 normal 25-30 overweight 30-35 class I obesity 35-40 class II >40 class III ```
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treatments for obesity?
``` bupropion-naltrexone (Contrave) orlistat - lipase inhibitor GLP-1 receptor agonist (Victoza) rx underlying factors or illness surgery: gastric bypass, sleeve gastrectomy, adjustable gastric band ```
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Smoking Cessation medications and CI
Bupropion - avoid if seizure d/o, eating d/o, EtOH w/d, MAOI use, allergy Varenicline (partial nicotine agonist) - now ok in psychiatric conditions
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AUD rx
1st line naltrexone (not in liver disease, OUD) others: acamprosate, gabapentin refer to counselling, set goals, eat when drinking
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OUD rx
OAT! side effects = constipation, amenorrhea, decreased testosterone treatment agreements UDS harm reduction - lock box, naloxone, don't use alone avoid cannabinoids, benzos, EtOH/sedatives
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Nexus C-spine rule | Exclusions (6)
Exclusions: acute paralysis, known vertebral disease, previous C-spine surgery, non trauma patients GCS <15, unstable vital signs, <16 ``` NO neuro deficit spinal tenderness midline alertness intoxication distracting injury ```
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Test for cervical radiculopathy
Spurling test - The Spurling test is a medical maneuver used to assess nerve root pain (also known as radicular pain). The examiner turns the patient's head to the affected side while extending and applying downward pressure to the top of the patient's head.
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Causes of unconjugated hyperbilirubinemia
``` ABC BILI ABO hemolysis Breast milk Conjugation defect - Gilbert’s syndrome Breastfeeding (dehydration) Infection Loss of blood Idiopathic (physiologic) ```
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Causes of conjugated hyperbilirubinemia?
BAD-C Biliary atresia Ductal stenosis Cystic fibrosis
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Modified CENTOR criteria
``` Cough absent Tonsils red or exudative Cervical lymph nodes Fever <14 +1 14-45 0 45+ - ```
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Causes of abnormal uterine bleeding
``` PPALMCOEIN Pregnancy ruled out Polyp Adenomyosis Légion Yona Malignancy and hyperplasia Coagulopathy Ovulatory dysfunction Endometrial Iatrogenic ```
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Features of renal artery stenosis
``` New HTN <30 or >55 Abdominal bruit Creatinine increases more than 30% with ACE or ARB HTN resistant to 3 or more meds Récurrent pulmonary derm with HTN surges ```
317
Bipolar medications in pregnancy advice
``` Lowest effective dose Avoid valproate Monotherapy Psychosocial preferred over meds in 1st trimester Restart medications after childbirth ```
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Classes of pharmacological treatment for endometriosis
GNRH antagonists (CI: postmenopausal or <18) Aromatase inhibitors NSAIDS hormonal contraception
319
The Menopause 5
Quit: smoking, alcohol, caffeine Start: exercise, weight loss Fan, layers, cool environment, no hot drinks, optimize sleep
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Menopause - 4 medication classes
``` SSRIs HRT -- safe for 5 yrs w/in 10 years of LMP, transdermal is best. No uterus? No progesterone OCP Progestin TCAs Anticonvulsants ```
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C/I to estrogen
``` migraine with aura smoker >35 CVD/valvular disease liver disease diabetes w/ end organ damage malignancy uncontrolled HTN ```
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Cat bite!
Amox-Clav if pen allergy - doxy or septra/flagyl don't close the wound dog bite less risk but consider in immunocompromised
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Rabies Rx
Dog/cat/ferret - observe for 10 days, at first sign of rabid, give Rabig and four doses of HDCV or PDECV and test animal Dog/cat/ferret/skunk/bat/fox/coyote/raccoon/carnivores that is suspected rabid - Rabig + fours doses of HDCV or PCECV, immediately test animal
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sedation of peds lac repair?
intranasal midazolam | IV/IM ketamine
325
sutures # of days
face - 5 joint, scalp 10-14 everything else -7
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``` Toxidromes for... Stimulant Anticholinergic Cholinergic Opioids Sedative-Hypnotics Benzos ```
Stimulant -- BIG pupils, use benzos Anticholinergic: TCAs, tegretol, anti-Parkinson's, antipsychotics, jimson weed -- use physostigmine. NO sweating Mad as a hatter, dry as a bone, red as a beet, hot as a hare, blind as a bat, full as a flask Cholinergic: mushrooms, organophosphates/insectiticides, nerve agents / sarin gas -- atropine, pralidoxime. Tiny pupils, increased sweating. SLUDGE = salivation, lacrimation, urinary incontinence, diarrhea, GI upset, emesis, miosis Opioids Sedative-Hypnotics: anti-epileptics, barbiturates, muscle relaxants. Depressed vitals. Benzos - give flumazenil (seizure risk)
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Antidotes for ... beta blockers? iron? Aceminophen?
BB - glucagon & CABs iron - deferoxamine & ABCs acetaminophen - N-acetylcysteine & ABCs
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If UTI 1st line abx fail...
reinfection vs. relapse treat 7-14 days reconsider dx/refer - upper tract imaging, cystoscopy, urodynamics
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causes and mgmt for epistaxis... mild? severe? Posterior?
``` 90% are anterior causes TIME to stop BLEED Trauma/tumor Infection Meds - nasal steroids Exogenous - foreign body BLEEDing disorders ``` Mgmt - mild: - blow nose - 2 sprays oxymetazoline - pinch x 10 minutes Severe: - ABCs, MOVIES, labs - tranexamic acid - freeze and cauterize or freeze and pack. Don't cauterize both sides! (Septal perforation) Posterior - identify by packing; if still bleeding, call ENT. Nasal baloon/foley.
330
Prophylaxis for those in close contact to bacterial meningitis?
Rifampin or ceftriaxone or ciprofloxacin
331
Croup management steroid dose? ddx? fup instructions for parents?
Mild - ABCs, treat fever, PO fluids, reassure parents Dexamethasone 0.15 (mild)-0.6mg/kg If severe, inhaled racemic epinephrine (if receives this, fup <24 hours post discharge) if given dex, should get better! If not, consider ddx: influenza, RSV, adenovirus, metapneumovirus, foreign body, tracheomalacia fever persistiting past 24-48 hours fluid intake or output not adequate fatigued/listless decreased LOC, respiratory distress
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Meningitis management, CSF findings
Start IV abx right away! They are a resuscitation drug. Steroids only if H flu and <2 hours from antibiotics Normal CSF findings: Bacterial: WBC >500 - neutrophils, low in glucose, protein >100 Aseptic, often viral i.e. syphillis: WBC 10-1000 - lymphocytes, normal glucose, protein <200 SAH: xanthochromia, normal glucose, elevated protein Fungal: WBC 10-500, cloudy, low glucose, elevated protein TB: 50-500 clear to opaque, low glucose, elevated
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Contraindications to LP
- blood pressure - shock - brain herniation - bleeding - coagulopathy - blisters - rash at site
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Anaphylaxis treatment
0.01 mg/kg 1:1000 IM ABC MOVIES SUPINE (unless seizure, pregnant, decreased LOC) EPI Allergy alphabet, rule of 5 Adrenaline 0.5mg Breathing - O2 5L nasal or 15L non rebreather Corticosteroid - methylprenisolone 125mg Diphenhydramine 50mg Epi again? Fluids - treat hypotension 2/2 vasodilation 500c Glucagon if on B-blocker H2 blocker - ranitidine 150mg Inhaled salbutamol - if wheezy observe for at least 4-8 hours, can have rebound in 23%; steroids don't help reduce this
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Eating d/o - SCOFF screening tool
Made yourself SICK because you felt uncomfortably full? Lost CONTROL over how much you eat? Recently lost more than ONE stone (14 lbs) in a 3 month period? Do you believe yourself to be FAT when others say you are too thin? Would you say that FOOD dominates your life?
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BMI in eating disorders
>17 mild 16+ moderate 15+ severe <15 extreme
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The new Female Athlete Triad
Relative Energy Deficiency in Sport RED-S
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Signs on exam of eating disorder
``` Bradycardia Slow cap refill Postural tachycardia Postural hypotension Decreased core temperature Pressure sores ```
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Emergency Contraception (4)
OCP Ullipristal Levonorgestrel Copper IUD
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Counselling after sexual assault, pregnancy, when to retest?
``` HIV post-exposure prophylaxis Hep B immune globulin, vaccinate within 8 hours Retest at 6, 12 weeks Azithro + cefixime/ceftriaxone Preg test in 4 weeks Reporting = voluntary unless <18 ```
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1st trimester bleeding
missed abortion? expectant vs. D&C vs. misoprostol Always remember your WinRHO if threatened, serial ultrasound/serial beta ectopic - pain, <7 weeks, tubal risk factors - expectant, medical or surgical
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Tests and managemnet for AUB
tests: Endometrial biopsy, colposcopy, Pap Management: Levonorgestrel IUS, OCP, progestin, NSAIDs(??), TXA Surgical - ablation, hysterectomy, polypectomy, myomectomy
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Test for vaginitis
``` Swabs/culture KOH Wet mount PH Biopsy ```
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To PSA or not to PSA And how to interpret RFs for prostate cancer
Discuss it if life expectancy >10 years Start at 50, or 45 if high risk PSA < 10 low risk, routine PSA 10-20 semiurgent PSA > 20 high risk, urgent PSA > 10 and abnormal prostate = urgent RFs: age, high risk race, family hx, smoking, obesity
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Physical exam/investigations for suspected BPH?
ABDO and rectal exam Midstream urine culture + sensitivity and analysis, GC/CT screening PSA if >10 year life expectancy
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BPH management Stop (7) Start (2)
1. Stop antihistamines, decongestants, NSAIDs, saw palmetto, excess fluid, caffeine, alcohol 2. Start 5-Alpha reductase inhibitor - Finasteride Alpha blocker - Tamsulosin (or both) Phosphodiesterase type 5 inhibitors - tadalafil Anti-muscarinics
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Risk factors for tubal dysfunction
Endometriosis, ectopic, surgery, Crohn's, PID, chlamydia, ruptured appendix
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Causes of infertility / workup | bloodwork to r/o hyperangronism
Anovulation Tubal dysfunction Uterine abnormalities - adhesions (surgery), septate/arcuate uterus, intracavitary fibroids Ovulation --> Day 3 FSH (ovarian reserve), Estrogen (ensure FSH not being suppressed), TSH, prolactin, midluteral progesterone Anti Mullerian hormone for women > 35 or with risk factors for low ovarian reserve: single ovary, ovarian surgery, poor response to FSH, chemo/radiation, unexplained infertility Hyperandrogenism --> DHEA-S, 17-OH progesterone, total testosterone Structural, tubal --> ultrasound, hysterosalpingogram Partner --> semen analysis Male Testicles - trauma, torsion, surgery, infection Sperm - tobacco, marijuana, hypogonadism
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When to refer for ?infertility
12 months if no risk factors 6months if risk factors or <35 immediately if >40 start exercise!
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PID symptoms, counselling
cervical motion tenderness, purulent discharge, fever treat partner contact tracing abstinence x 7 days
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Ages for abuse
``` 16 if non exploitative 18 if exploitative consenting youth 12-13 -- up to 2 years older 14-15 -- up to 5 years older` ```
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PreP recommended for :
MSM trans people having condomless anal sex with HIV+/unknown status partners might benefit: - IVDU - hetero people with HIV+ partners with detectable viral loads
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How to start PREP, counselling?
Truvada one pill per day or on demand Doesn't protect from other STIs, use condoms Baseline labs: STI screen CBC/Hgb Creat HCG urinalysis - q3 montly lab fup
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Priapasm management
Doppler ultrasound, cavernosal blood gas Non ischemic? watch and wait - finasteride - gonadotropic-releasing hormone agonists - Leuprolide Ischemic - needle drainage - intracavernosal phenylephrine - surgical shunt if >48 hours
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Bloodwork for ED
Serum glucose Chol HDL LDL Trig non-HDL Testosterone Prolactin TSH LH FSH
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Semen analysis
Most important results are CONCENTRATION (>15 million/ml) and MOTILITY (>40%) morphology less important
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Heart failure treatment
``` ACE/ARB Betablocker Mineralocorticoid Lasix AND if HFrEF (EF <40%), add SGLT2 even if no DM2 ``` If HFpEF, add SGLT2 if DM2/CVD, >30yo w/ DM2/CKD, >50yo w/ DM2 and risk of CVD If ongoing symptoms despite triple therapy, add entresto for NYHA II to IV If Heart rate > 70, also add Ivrabradine
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When to suspect cardiac amyloid and what to order
``` “Frequent” and “underlooked” Occurs in 1 in 4 over 80 yrs old  If HF unexplained, or associated with neuropathy or carpal tunnel (bilateral): Order SPEP, UPEP & serum free light chains Monoclonal protein:  Absent: Tc-99m-PYP SPECT scan  Present: Refer to hematology for biopsy ```
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Microcytic anemia
``` Thalassemia Anemia of chronic disease Iron deficiency Lead poisoning Sideroblastic anemia ```
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Macrocytic anemia
M FAT RBC ``` Myelodysplasia Fetal hgb/folate deficiency Alcohol Thyroid Reticulocytosis B12 deficiency Chronic disease ```
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Normocytic anemia
``` HARPS normocytic Hemolytic anemia Anemia of chronic disease Renal failure Pregnancy/pernicious anemia/pyridoxine deficiency Spherocytosis ```
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Anemia workup
```  Hemoglobin  Mean cell volume  Serum Ferritin  Peripheral Blood Smear  Serum Iron  Total Iron Binding Capacity  Colonoscopy  HCG ``` Elevated RDW = iron deficiency Low/normal RDW = thalassemia - hgb electrophoresis
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B12 DEFICIENCY | Risk Factors
``` 1. Gastric surgery Gastric parietal cells make intrinsic factor 2. Strict vegans 3. Breastfed children of #2 4. Elderly 5. Psychiatric ```
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Iron for peds?
FERROUS SULFATE FOR SMALL ONES
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Causes of recurrent UTI in peds:
VUR Uretrocele Posterior urethral valves
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Causes of unconjugated hyperbilirubinemia?
ABC Bili - unconjugated ABO hemolysis Breastmilk Conjugation deficiency Breastfeed, lack of - dehydration Infection Loss of blood, vit K deficiency Idiopathic
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Causes of conjugated hyperbili?
Bad C Bili - conjugated Biliary atresia Biliary duct stenosis Cystic fibrosis
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C diff test
Stool PCR For c diff toxin A and B
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Ottawa Ankle Rule
An ankle X-Ray series is only required if there is any pain in the malleolar zone and... Bone tenderness at the posterior edge or tip of the lateral malleolus (A) OR Bone tenderness at the posterior edge or tip of the medial malleolus (B) OR An inability to bear weight both immediately and in the emergency department for four steps
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Ottawa Foot Rule
A foot X-Ray series is only required if there is any pain the midfoot zone and... Bone tenderness at the base of the fifth metatarsal (C) OR Bone tenderness at the navicular (D) OR And inability to bear weight both immediately and in the emergency department for four steps
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Ottawa Knee Rule
knee X-Ray series is only required for knee injury patients with any of these findings: Age 55 or older OR Isolated tenderness of the patella No bone tenderness of knee other than patella OR Tenderness of the head of the fibula OR Cannot flex to 90 degrees OR Unable to bear weight both immediately and in the emergency room department for 4 steps Unable to transfer weight twice onto each lower limb regardless of limping
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Wells Criteria for DVT
Active cancer Treatment or palliation within 6 months Bedridden recently >3 days or major surgery within 12 weeks Calf swelling >3 cm compared to the other leg Measured 10 cm below tibial tuberosity Collateral (nonvaricose) superficial veins present Entire leg swollen Localized tenderness along the deep venous system Pitting edema, confined to symptomatic leg Paralysis, paresis, or recent plaster immobilization of the lower extremity Previously documented DVT Alternative diagnosis to DVT as likely or more likely
373
Zika counselling
- do not get pregnant if travelling to Zika-risk country - mosquito precaustions If traveler is female: Consider using condoms or not having sex for at least 2 months after travel to an area with risk of Zika (if she doesn’t have symptoms), or for at least 2 months from the start of her symptoms (or Zika diagnosis) if she develops Zika. If traveler is male: Consider using condoms or not having sex for at least 3 months after travel to an area with risk of Zika (if he doesn’t have symptoms), or for at least 3 months from the start of his symptoms (or Zika diagnosis) if he develops Zika.
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Schizophrenia symptoms
Positive (i.e. hallucinations, delusions, racing thoughts), negative (i.e. apathy, lack of emotion, poor or nonexistant social functioning), and cognitive (disorganized thoughts, difficulty concentrating and/or following instructions, difficulty completing tasks, memory problems)
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SADMAN drugs
``` Sulfonylureas ACE Diuretics - spironolactone Metformin ARBs NSAIDs SGLT2 ```
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PE Wells Criteria
Clinical signs and symptoms of DVT PE is #1 diagnosis OR equally likely Heart rate > 100 Immobilization at least 3 days OR surgery in the previous 4 weeks Previous, objectively diagnosed PE or DVT Hemoptysis Malignancy w/ treatment within 6 months or palliative
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PERC score
Age ≥50 HR ≥100 O₂ sat on room air <95% Unilateral leg swelling Hemoptysis Recent surgery or trauma Surgery or trauma ≤4 weeks ago requiring treatment with general anesthesia Prior PE or DVT Hormone use Oral contraceptives, hormone replacement or estrogenic hormones use in males or female patients
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Murmur for hypertrophy cardiomyopathy
Significant LVOT obstruction, often due to a combination of LV upper septal hypertrophy and systolic anterior motion (SAM) of the mitral valve, results in a harsh crescendo-decrescendo systolic murmur that begins slightly after S1 and is heard best at the apex and lower left sternal border. An increase in intensity, due to enhancement of obstruction, is seen with the assumption of an upright posture from a squatting, sitting, or supine position; the Valsalva maneuver; during the more forceful contraction that follows the compensatory pause after a PVC; and following the administration of nitroglycerin. ●A decrease in intensity, due to attenuation of obstruction, is heard after going from a standing to a sitting or squatting position, with handgrip, and following passive elevation of the legs.
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Stevens Johnsons syndrome, presentation and management
- Risk limited to the first eight weeks of treatment. - typical exposure period before reaction four days to four weeks of first continuous use of the drug. - Fever, often exceeding 39°C and influenza-like symptoms precede by one to three days the development of mucocutaneous lesions - Photophobia, conjunctival itching or burning, and pain on swallowing may be early symptoms of mucosal involvement. Malaise, myalgia, and arthralgia are present in most patients. - Signs and symptoms that should alert the clinician to the possibility of SJS/TEN include fever >38°C (100.4°F), mucositis, skin tenderness, and blistering - Nikolsky sign - labs: Complete blood count with differential, metabolic panel (ie, glucose, electrolytes, blood urea nitrogen, creatinine, calcium, total protein, albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase), erythrocyte sedimentation rate, and C-reactive protein --> chest xray due to high risk of pneumonia ●Bacterial and fungal cultures should be performed from blood, wounds, and mucosal lesions. Because of the high risk of bacterial superinfection and sepsis in these patients, cultures should be repeated throughout the acute phase of the disease. Management: referral to the most appropriate health care setting (eg, intensive care unit, burn unit, specialized dermatology unit, where present), and initiation of supportive treatment. - wound care, fluid and electrolyte management, prompt withdrawal of offending agent, pain control, prevention/treatment of infections
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what is sarcoidosis?
Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that affects individuals worldwide and is characterized pathologically by the presence of noncaseating granulomas in involved organs. It typically affects young adults and initially presents with one or more of the following abnormalities: ●Bilateral hilar adenopathy ●Pulmonary reticular opacities ●Skin, joint, and/or eye lesions
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what is acute aortic syndrome?
It is a clinical spectrum of diagnoses including aortic dissection, intramural hematoma and penetrating atherosclerotic ulcer at any location along the aorta
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Meniere's disease
Tinnitus, vertigo, hearing loss, nausea/vomiting (clinical dx; rarely may do MRI) From build up of fluid in the ears, occurs in episodes Treatment: symptoms - anti-emetic: promethazine, prochloperazine treat of fluid build up - diuretics (HCTZ, acetazolamide), low salt diet Toxic labyrinthitis -- related to EtOH
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Signs of advanced HF
2 or more hospitalization or ED for HF visits in the past year progressive deterioration of renal function weight loss without other cause = cardiac cachexia stop ACE due to hypotension or worsening renal failure intolerance of bblockers because of worsening HF or hypotension SBP < 90 NYHA class III or IV need to escalate diuretics to maintain volume status, often reaching furosemide > 160 or supplemental metolazone rx progressive decline in serum sodium frequent implantable cardioverter debrillator shocks
384
Who do you give pneumococcal vaccine to, and which one?
It is recommended that immunosuppressed adults of all ages receive the 13-valent pneumococcal conjugate vaccine (PCV13) all adults aged 65 years and older receive PCV13 on an individual basis, followed by the 23-valent pneumococcal polysaccharide vaccine One dose of Pneu-P-23 vaccine should be administered to all individuals 24 months of age and older who are at high risk of IPD due to an underlying medical condition or who are residents of long-term care facilities. People at highest risk of IPD should also receive 1 booster dose of Pneu-P-23 vaccine. One dose of Pneu-P-23 vaccine is recommended for adults: 65 years of age and older, regardless of risk factors or previous pneumococcal vaccination. at high risk of IPD due to lifestyle factors: smokers, persons with alcoholism, persons who are homeless. Adults who use illicit drugs should be considered for Pneu-P-23 vaccination. Why S. pneumoniae is a common cause of invasive disease, such as bacteremia and meningitis. The case fatality rate of bacteremic pneumococcal pneumonia is 5% to 7% and is higher among elderly persons.
385
What is degenerative cervical myelopathy and how do you treat it?
Degenerative cervical myelopathy occurs when age-related osteoarthritic changes cause narrowing of the cervical spinal canal, leading to chronic spinal cord compression and resultant neurologic disability. The natural course of DCM presents as a stepwise decline, with symptoms ranging from muscle weakness to complete paralysis. All individuals with signs and symptoms should be referred to a spine surgeon for consideration of surgery. Asymptomatic patients with evidence of cord compression on magnetic resonance imaging might need to be referred for assessment; however, surgery is not advised. It is critical to closely monitor asymptomatic individuals or those with mild DCM for neurologic deterioration. Patient presentation can vary broadly, with symptoms ranging from mild dysfunction, such as numbness or dexterity problems, to severe dysfunction, such as quadraparesis and incontinence, as later findings. It is important to note that paresthesia in the extremities is often the first sign, and because it might be mild, it can be easily overlooked by patients and providers.
386
What is a tool that uses lab values to predict cirrhosis?
AST to Platelet Ratio Index (APRI) APRI score greater than 1.0 had a sensitivity of 76% and specificity of 72% for predicting cirrhosis. In addition, they concluded that an APRI score greater than 0.7 had a sensitivity of 77% and specificity of 72% for predicting significant hepatic fibrosis. Similarly, the FIB-4 score uses the AST/ALT, age and platelet levels to predict the level of fibrosis using a different equation.
387
Treatment for rosacea
``` Topical - metronidazole azelaic acid invermectin minocycline ``` Oral - doxycycline minocycline tetracycline persistent erythema - brimonidine gel oxymetazoline persistent erythema/telangectasia - laser
388
Questions from the Cannabis Abuse Screening Test?
Have you smoked cannabis before midday? Have you smoked cannabis when you were alone? Have you had memory problems when you smoked cannabis? Have friends or members of your family told you that you ought to reduce your cannabis use? Have you tried to reduce or stop your cannabis use without succeeding? Have you had problems because of your use of cannabis (argument, fight, accident, bad result at school, etc)? Which ones?
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What is POMI?
Prescription Opioid Misuse Index 1. Do you ever use more of your medication, that is, take a higher dose, than is prescribed for you? 2. Do you ever use your medication more often, that is, shorten the time between doses, than is prescribed for you? 3. Do you ever need early refills for your pain medication? 4. Do you ever feel high or get a buzz after using your pain medication? 5. Do you ever take your pain medication because you are upset, using the medication to relieve or cope with problems other than pain? 6. Have you ever gone to multiple physicians, including emergency room doctors, seeking more of your pain medication?
390
Breastfeeding safe medications
Allergic rhinitis Beclomethasone (Beconase) Fluticasone (Flonase) Cromolyn (Nasalcrom) Cardiovascular Hydrochlorothiazide (Esidrix) Metoprolol tartrate (Lopressor) Propranolol (Inderal) Labetalol (Normodyne) ``` Nifedipine (Procardia XL) Verapamil (Calan SR) Hydralazine (Apresoline) Captopril (Capoten) Enalapril (Vasotec) ``` ``` Use with caution: Atenolol (Tenormin) Nadolol (Corgard) Sotalol (Betapace) Diltiazem (Cardizem CD) ``` Depression Sertraline (Zoloft) Paroxetine (Paxil) Nortriptyline (Pamelor) Desipramine (Norpramin) Use with caution: Fluoxetine (Prozac) Diabetes Insulin Glyburide (Micronase) Glipizide (Glucotrol) Tolbutamide (Orinase) Acarbose (Precose) Use with caution: Metformin (Glucophage) Thiazolinediones Epilepsy Phenytoin (Dilantin) Carbamazepine (Tegretol) ``` Ethosuximide (Zarontin) Valproic sodium (Depakote) ``` Use with caution: Phenobarbital Pain Ibuprofen (Motrin) Morphine Acetaminophen (Tylenol) Use with caution: Naproxen (Naprosyn) Meperidine (Demerol) Asthma Cromolyn (Intal) Nedocromil (Tilade) Fluticasone (Flovent) Beclomethasone (Beclovent) Contraception Barrier methods Progestin-only agents
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Risks of opthalmic steroids
1. PERFORATION: In the event of herpetic keratitis, steroids can facilitate progression resulting in corneal perforation 2. GLAUCOMA: Ophthalmic steroids can cause chronic open-angle glaucoma if used for a prolonged period of time (i.e. > 2 weeks) 3. CATARACTS: Ophthalmic steroids can cause cataracts if used for a prolonged period of time 4. CORNEAL ULCERS: Ophthalmic steroids have been associated with development of corneal ulcers of a fungal origin.
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What are the ABCDEF of red eye?
A = ache, B = blob, C = constriction, D = document acuity, E = erythema pattern, F = flourescin
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Iritis
Remember anatomically what the IRIS is (coloured part of the eye), what the IRIS does (constricts in response to light), and what it surrounds (pupil): It makes sense that if the iris is inflamed… - it will be red around the iris (PERILIMBAL HAZE) - it hurts when the iris constricts (PHOTOPHOBIA) - it can become warped (DISTORTED PUPIL) A • Pain - Photophobia B • Yes, watery C •Miosis / reacts poorly on affected side / distorted pupil (anisocoria) D • Blurred vision E • Perilimbal Haze F •Normal •Not necessary unless FB sensation * Refer for Steroids * R/O systemic cause (i.e. SpA, Behcet's , IBD, Kawasaki's, TINU, JIA, Sjögren's, Polychondritis, Granulomatous Tx) angiitis...) DDx – Unlike Iritis… Conjunctivitis has morning crusting, no pain Sclerits has SEVERE pain & tenderness to palpation Episcleritis is NOT painful Keratitis has corneal opacity, discharge, fluoresces Glaucoma has hazy, nonreactive pupil & headache
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Scleritis
Remember the sandwich, from superficial to deep: CONJUNCTIVA EPISCLERA SCLERA As the deepest part of the eye, the eye will be will be VERY VERY PAINFUL if the inflammation gets all the way down to the sclera. A • SEVERE CONSTANT BORING PAIN - ++ night, pain w/palpation, + photophobia B • Tears C • PERL D • Decreased - DOCUMENT E • No erythema...but deep red / blue / purple hue F •Normal •Not necessary unless FB sensation •REFER for Steroids •R/O systemic cause (RA, IBD, microscopic polyangiitis, Churg-Strauss, Sjogren's, Polychondritis, Granulomatous angiitis, Tx SLE, infectious)
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Episcleritis
Remember the sandwich, from superficial to deep: CONJUNCTIVA EPISCLERA SCLERA The episclera is not the deepest part, so there’s no pain & normal acuity. As well, it’s sealed in by conjunctiva so there’s no significant discharge & no A.M. crusting. Focal redness-think Episcleritis. ``` A •Irritation (pain is rare) B •Tears - NO pus, NO a.m. crusting C •PERL D • Normal- DOCUMENT E •FOCAL redness F •Normal •Not necessary unless FB sensation Tx •Artificial Tears ```
396
Keratitis
Keratitis is inflammation of the cornea. Think about how painful a corneal abrasion is and you’ll remember keratitis. These patients are miserable. Also, if the CORNEA is inflamed, ACUITY will obviously be decreased as light passes through the cornea. Don’t forget FLOURESCIN staining as this will give away the diagnosis of keratitis! ``` A •Difficulty keeping eye open •VIRAL - Watery B •BACTERIAL - Possibly Purulent C •PERL but you may notice a haze or branching pattern on the cornea D •Blurred vision •Halos around lights E •Diffuse (maybe perilimbal) •Corneal haze F •+ HSV - Branching pattern •+ Bacterial - Corneal Ulceration ``` Tx •REFER URGENTLY •Ophtho will target instigating bug
397
Conjunctivitis
A No pain just irritation! If it's painful, it's not conjunctivitis B •Viral/Allergic: Watery esp. in AM •Bacterial: PUS esp. in AM C •PERLA. (If abnormal, it's not conjunctivitis) D •Normal -DOCUMENT E •Diffuse •Normal F •Not necessary unless FB sensation •SWABS = USELESS (exceptions: contact lens wearer, painful, failed Tx, immunocompromised) Tx •ABx for Bacterial (cover for Pseudo if contacts)
398
Glacuoma
Remember the rule of thumb: REFER all patients with any PAINFUL EYE. And – look for red eye if your patient has serious headache. If you do this you won’t miss a rare, but serious, glaucoma. A good analogy is the eye is like an overinflated balloon, ready to pop… imagine how PAINFUL that would be. These patients are often IN DISTRESS. As well an overinflated eyeball won’t function normally – pupil FIXED and DECREASED acuity. ``` •Acute, SEVERE Pain, Tender, & firm - these patients are in distress B •Minimal Watery C •Fixed, Hazy, Dilated •Anisocoria D • Decreased - DOCUMENT • Halos around lights E •Ciliary Flush F •Normal •Not necessary unless FB sensation ``` Tx •LOWER PRESSURE within HOURS •IMMEDIATE REFERRAL to ED Acute Angle-Closure Glaucoma Emergent Treatment  Consult Ophthalmology Emergently  Initiate treatment WITHIN 60 MINUTES as recommended by ophthalmology A sample regimen may include:  0.5% timolol maleate  1% apraclonidine, and 1 gtt each, to affected eye, 1min apart  2% pilocarpine  Oral medications may include acetazolamide, two x 250mg tablets in the office  IV medications may include acetazolamide or mannitol
399
Approach to vertigo
Classifying vertigo or dizziness by timing (episodic or continuous) and trigger (positional or not), rather than type (vertigo vs lightheadedness vs unsteadiness, etc) allows for effective clinical identification of both high-risk-for-stroke and low-risk-for-stroke populations.” Consider POSTERIOR STROKE in ANY patient with dizziness, nausea, vomiting. Symptoms can also include swallowing difficulties, facial pain with vertigo or numbness, or gait disturbance
400
Vertigo red flags
``` Red flags: hearing loss, new, unilateral focal neuro headache, new head impulse that suggests central cause (no corrective saccade) ``` Pitfall: Don’t use the Dix-Hallpike Maneuver on patients with continuous vertigo symptoms Only perform this maneuver on patients whose episodes of vertigo last less than 2min, and have no nystagmus at rest. Note that most types of vertigo will be exacerbated by head movements. Even with episodic vertigo, the feeling of nausea can persist, which can be confusing. The key is that BPPV has provoked brief episodes that resolve, and there are no nystagmus present at rest. Peripheral Head Impulse - Catch-up saccade ("abnormal") Nystagmus - unidirectional Test of Skew - No vertical skew Hearing loss absent ``` Central Head Impulse - Normal gaze tracking Nystagmus - bidirectional Test of Skew - Vertical skew present Hearing loss present ``` Pitfall: Don’t use the HINTS Plus exam on patients with BPPV (episodic vertigo without nystagmus at rest) This is only indicated for patients with ongoing, constant vertigo and nystagmus at rest. The results are meaningless and confusing when performed on patients with suspected BPPV.
401
Validated score for Autism?
M CHAT RF
402
How is long QT defined? Risk factors (6) and medications to avoid for TdeP (4)?
MEN QTc > 450, WOMEN QtC > 460 ``` congenital long QT syndrome older age previous TdeP electrolyte abnormalities: low K, low Mg, low Ca bradycardia female ``` ``` Meds: domperidone citalopram macrolides quinolones ```
403
How to reduce recurrent UTIs in premenopausal women
increase daily water consumption by 1.5L/day
404
Reasons to prescribe abx when doing an I+D?
extensive tissue damage, risk of poor healing/complications, immunocompromised, prosthetic device --> if MRSA, add clinda or septra
405
Tool for suspected concussions in sport? | questions to ask before someone can consider return to sport?
SCAT-5 sport concussion assessment tool to return to sport: are all symptoms resolved? unrestricted return to normal cognitive activity achieved? endurance and physical activities performed without symptoms? normal exam of cervical spine and neurologic status? any other health condition/previous concussion/context to justify an additional delay?
406
criteria for admission for anorexia nervosa
``` weight <75% of ideal body weight temp < 35.5 HR 45 SBP <80 orthostatic change in pulse >20 orthostatic change in BP >10 ```
407
Rourke Baby nutritional recommendations
avoid hard/small/round foods until 3 years. Remain seated while eating/drinking Promote family meals with self-feeding avoid all sweetened beverages Vit D supplementation 400IU and 800IU in high risk infants while breastfed early introduction starting at 6 months and repeated ingestion of allergenic foods like egg, fish, peanut
408
Child safety advice
Rear facing car seat until 2 years of age and then booster seat for 40-80 pounds Sleep in crib/cradle/bassinet without soft objects/loose bedding in parents room for 6 months after umbilical stump detaches, should have supervised tummy time vary the direction of the infants head while supine Swaddling not recommended after 2 months