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Immunology > CD Markers and ILs- > Flashcards

CD Markers and ILs- Flashcards

1
Q

CD19

A

B cells

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2
Q

CD14

A

Monocytes

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3
Q

CD3

A

T cells

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4
Q

CD4

A

Helper T cells

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5
Q

CD8

A

Killer T cells

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6
Q

CD4+CD25+FoxP3

A

T regulatory cells

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7
Q

CD56

A

NK cells

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8
Q

CD21 (CR2)

A

B cells

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9
Q

CD28

A

T cells

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10
Q

CD154 (CD40L)

A

T cells

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11
Q

CD80/86 (B7.1/B7.2)

A

Antigen Presenting Cell

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12
Q

CD40

A

B cells, some macrophages

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13
Q

IL1

A

Signs of inflammation
Increased vascular permeability/adhesiveness and diameter
Activates JaK-STAT pathway

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14
Q

IL2

A

Drives lymphoid lineage
Important in T cell development
With IL4, induces Th2 cells

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15
Q

IL3

A

Drives myeloid lineage differentiation

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16
Q

IL4

A

Induces Th2 cell differentiation
Secreted by Th2 cells
Drives antibody secretion in B cells

17
Q

IL5

A

Stimulates B cell proliferation
Activates eosinophils

18
Q

IL6

A

Induces fever
Induces production of acute phase proteins from liver

19
Q

IL7

A

Drives lymphoid lineage differentiation
Drives T cell differentiation in thymus

20
Q

What is another name for IL8?

A

CXCL8

21
Q

IL8 (CXCL8)

A

Chemoattractant for neutrophils

22
Q

IL9

A

Suppresses apoptosis
Induces proliferation in WBC

23
Q

IL10

A

Anti-inflammatory
Secreted by Treg cells to suppress other T cell types
Secreted b M2 type macrophages

24
Q

IL12

A

Drives Th1 development
Secreted by M1 type macrophages and Th1 cells

25
Q

TGF-Beta (Transforming Growth Factor Beta)

A

Inhibits B cells and M1 macrophages
Induces differentiation of CD4 Th cells into Treg cells and Th17 cells

26
Q

Tumor necrosis factor

A

Similar effects as IL1
Can induce apoptosis by binding to its receptor

27
Q

IFN-alpha and IFN-beta

A

Type 1 interferons
Activate antiviral responses

28
Q

IFN-gamma

A

Type 2 interferon
Secreted by Th1 cells
Important for maintenance of granulomas

Immunology (4 decks)

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