CD's and cytokines Flashcards
(23 cards)
CD3
Main cellular expression: all T cells
Fx: associates with the TCR and mediates TCR signaling
CD4
Other names: Main cellular expression: T helper, MHC class II reactive T cells, monocytes, macrophages Fx: binds to MHC class II and helps in signaling for MHC II reactive T cells, binds to HIV
CD8
Other names: Main cellular expression: CTLs, MHC class I reactive T cells Fx: binds to MHC class I and helps in signaling for MHC I reactive T cells
CD28
Other names:
Main cellular expression: T cells
Fx: Costimulatory molecule for T cell activation, binds to CD80 and CD86
CD40
Other names:
Main cellular expression: B cells, macrophages, DCs
Fx: Binds to CD154, involved in activation of B cells, DCs and macrophages
CD80
Other names: b7, b7-1
Main cellular expression: B cells, macrophages, DCs
Fx: binds to CD28 and CTLA-4, costimulator for T cell activation
CD86
Other names: b7-2
Main cellular expression: B cells, macrophages, DCs
Fx: binds to CD28 and CTLA-4, costimulator for T cell activation
CD95
Other names: Fas, APO-1
Main cellular expression: activated T and B cells, monocytes
Fx: induces apoptosis upon interaction with CD178
CD154
Other names: CD40 ligand, CD40L
Main cellular expression: activated CD4+ T cells
Fx: Binds to CD40 activates B cells, DCs, and macrophages
CD178
Other names: Fas-ligand
Main cellular expression: Induced on T cells and NK cells
Fx: Binds to Fas and induces apoptosis on Fas+ cels; important for regulation of the immune response
“CD molecules”
Cluster of differentiation
Denotes cell surface molecules - either antigens, receptors, etc
“Cytokine”
Any intercellular mediator involved in immune function Includes interleukins (IL), tumor necrosis factors (TNF), interferons, etc
IL-1
Main immune cell source: macrophages, B cells, NK cells
Other sources: endothelium, fibroblasts, astrocytes, etc
Targets: T cells, B cells, macrophages, endothelium
Effects: lymphocyte activation, macrophage stimulation, inc leukocyte-endothelium adhesion, acute phase proteins, fever
IL-2
Main immune cell source: T cells
Other sources:
Targets: T cells, NK cells
Effects: T cell and NK cell activation and proliferation
IL-4
Main immune cell source: T cells, Th2 cells, mast cells
Other sources:
Targets: B cells, T cells
Effects: B cell growth factor, isotope switching to IgE, Th2 cell differentiation, suppress Th1 cells
IL-5
Main immune cell source: T cells, mast cells, Th2 cells
Other sources:
Targets: B cells
Effects: B cell growth factor, isotope switching to IgA, eosinophil growth
IL-6
Main immune cell source: T cells, B cells, macrophages
Other sources: endothelium, fibroblasts, astrocytes, stromal cells, etc
Targets: T cells, B cells, macrophages
Effects: induces acute phase response, regulates Th17 differentiation and proliferation of antibody producing cells
IL-10
Main immune cell source: T cells, Th2 cells
Other sources:
Targets: Th1 cells
Effects: inhibition of cytokine synthesis and macrophage function
IL-12
Main immune cell source: monocytes, APCs
Other sources:
Targets: Th1 cells, NK cells
Effects: differentiation of Th1 cells, activation of NK cells
TNF-alpha
Main immune cell source: lymphocytes, macrophages, mast cells
Other sources:
Targets: many cells
Effects: pro inflammatory, endothelial activation, shock, acute phase proteins, PMN activation
TGF-beta
Main immune cell source: T cells, monocytes
Other sources: most cells
Targets: most cells
Effects: inhibits cell activation, anti-inflammatory, promotes IgA secretion
Interferon-alpha/beta
Main immune cell source: most cells
Other sources: most cells
Targets: most cells
Effects: antiviral, increased MHC class I expression
Interferon-gamma
Main immune cell source: NK cells, T cells
Other sources:
Targets: macrophages, B cells, endothelium, DCs
Effects: increased MHC class II expression, macrophage activation, IgG class switching, suppress Th2 cells
