Cell Death, Core Genes, & BCL-2 Family Function Flashcards
(30 cards)
What is the Greek origin and meaning of the term “apoptosis”?
How does apoptosis differ from necrosis in terms of inflammation?
What are the key functions of cell death in organisms?
How do trophic factors influence neuron survival during nervous system development?
Which organism was used in pioneering studies to isolate core cell death genes?
Name the four core cell death genes identified in C. elegans.
What is the mammalian homologue of the C. elegans ced-9 gene?
Which protein family does Bcl-2 belong to, and what is its role?
What are the two main apoptotic pathways in mammalian cells?
How does the extrinsic apoptotic pathway initiate cell death?
What role does Cytochrome C play in the intrinsic apoptotic pathway?
Describe the function of the apoptosome in cell death.
How do pro-survival Bcl-2 family members prevent apoptosis?
What is the role of Bax and Bak in mitochondrial membrane permeability?
How do BH3-only proteins contribute to apoptosis regulation?
What is the relationship between p53 and apoptosis?
How can cell survival be enhanced by suppressing apoptosis?
What is the significance of Bcl-2 overexpression in follicular lymphomas?
Explain the concept of BH3 mimetics in cancer therapy.
What is ABT-199/venetoclax, and for which condition was it approved?
How do BH3 mimetics target different pro-survival BCL-2 family members?
What is meant by “priming” of cancer cells in the context of BH3 mimetics?
How does the balance between anti-apoptotic and pro-apoptotic signals determine cell fate?
What role does the Apaf-1 protein play in the apoptotic process?
