Cell death in the developing NS Flashcards Preview

BMS236 Building the nervous system > Cell death in the developing NS > Flashcards

Flashcards in Cell death in the developing NS Deck (9)
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1

In C.elegans what type of cells do cells prevented from apoptosis normally become and what does this suggest

Neurons - suggests cell death acts to limit the number of neurons present in the mature C.elegans

2

What family of genes are responsible for apoptosis in C.elegans and what arises from KO of these genes

ced
ced-3/4 KO - excess numbers of adult cells
ced-9 massive cell death

3

What is the role of ced-9

Protects cell from apoptosis

4

What is the role of ced -4/3

Promotes apoptosis

5

What is the name of the protein coded for by the ced-3 gene

Caspase - proteolytic enzyme

6

What percentage of neurons are lost during development

50

7

What are the two triggers for developmental apoptosis

1. Lack of neurotrophic factors present
2. Absence of depolarising stimulus

8

What role do neurotrophins have in apoptosis (and their receptors)

Reduction in neurotrophins from sympathetic ganglia - have high P75-NTR (low TKC) - activates P75 - NTR results in a cell death signal for apoptosis

9

What is neurotrophin release dependent on

Calcium release - triggered by depolarising or ligand binding - more efficient synapse have more stimulated release - more binding and uptake by membrane recycling thus have a greater presynaptic effect - more target tissue results in more release of neurotrophins