Cell death, Senescence & Apoptosis Flashcards
Time dependent progressive decline of an organism showing loss of physiological competence resulting in degenerative pathologies and enhanced susceptibility to age related diseases is termed as _______.
Ageing
Time dependent progressive decline of an organism showing loss of physiological competence resulting in degenerative pathologies and enhanced susceptibility to age related diseases is termed as _______.
Ageing
Which of the following is not a characteristic feature of ageing?
a. It is time-independent
b. represents loss of physiological competence
c. results in degenerative pathologies
d. results from time-dependent accumulation of cellular damage.
e. decreased susceptibility to age-related disorders.
f. Both a &e.
f. Both a &e
In which of the following cells undergo an irreversible cell cycle arrest?
a. Senescence
b. Quiescence
a. Senescence
True/False:
a. Apoptosis is a passive cellular death process.
b. Cells undergo lysis in apoptosis.
c. Membranes forms bleb in apoptosis.
d. Cells swell and burst in apoptosis.
e. Apoptosis is immunologically silent process.
a. False
b. False
c. True
d. False
e. True
Which of the following is not a feature of cells undergoing apoptosis?
a. Apoptotic bodies are formed.
b. Chromatin fragmentation takes place.
c. Massive inflammation takes place.
d. Cells shrink in size.
c. Massive inflammation takes place.
Which of the following is not a feature of cells undergoing apoptosis?
a. Apoptotic bodies are formed.
b. Chromatin fragmentation takes place.
c. Massive inflammation takes place.
d. Cells shrink in size.
c. Massive inflammation takes place.
Who gave the 9 hallmarks of ageing?
Lopin et al.
Which of the following is a hallmark of ageing cell?
a. Loss of proteostasis.
b. Genome integration into foreign cell.
c. Telomeric elongation.
d. Deregulation of nutrient sensing pathways
e. Both a&d
f. None of the above.
e. Both a&d
Epigenetic changes does not lead to :
a. Enhanced DNA repair
b. Genome instability
c. Ageing
d. Changes in transcription and RNA processing.
e. All of the above.
a. Enhanced DNA Repair.
Correct- Leads to damages / defects in DNA repair.
Which of the following epigenetic changes will not lead to ageing?
a. Decreased local methylation and increased global methylation
b. Changes in silencing proteins
c. Changes in nuclear remodelling factors
d. Acetylation of DNA and Histones
e. Methylation of DNA and Histones
a. Decreased local methylation and increased global methylation.
Telomeric attrition can results in :
a. Production of dicentric chromosomes
b. ageing
c. misregulation of gene expression
d. abnormal fusion between two chromosomes
e. Telomere shortening
f. Loss of genetic information near the ends of the chromosomes
g. All of the above
h. Both a&b
g. All of the above
What is the cause of telomeric attrition which leads to ageing?
Absence or presence of inactive form of TELOMERASE enzyme which maintains the ends pf chromosomes.
Impairment in which of the following pathway will lead to ageing due to proteotoxic effect and loss of proteostasis?
a. Ubiquitin- Proteasome Mediated Degradation of unfolded proteins
b. Chaperone Mediated Refolding
c. Autophagy of unfolded or abnormal proteins
d. All of the above.
