Cell ECM (might not study this one) Flashcards
Describe Glycoproteins of ECM
a. Explain how glycoprotiens initate formation of cell-ECM junctions via integrin receptors in both dynamic focal contacts _ stable hemidesmosomes
b. Define ‘fibronectin’ and ‘laminin’ and explain where theyse proteins are most prominent
Describe 4 basic tissues + explain cellular interactions with ECM
Describe general features of extracellular matrix
a. Explain how ECM is supportive + instructive to tissue cells
b. Compare + Contrast interactions between cells + ECM in epithelilial connective tissues
c. Understand ECM structural porperties vary depending on 3 components: ground substance, fibers, and glycoproteins
Describe Ground substance of ECM
a. Identify 2 components of ground substance _ explain how molecules are important for hydrating ECM
b. define glycosaminoglycans’ (GAGs) + understand how they lead to hydration of ECM (provide example of GAG and its cell surface receptors
c. Define proteoglycans + understand why bulky, space-filling nature is important for ECM functino (provide example)
d. Understand that CD44 is a transmembrane protein that is a receptor for GAG hyaluronan (CD44 interacts w/ scaffolding protines –> ECM is mechanically linked to cytoskelton acroos plasmamembrane)
Describe fibers of ECM
a. Identify 2 types of fibers in ECM and explain how they are important for giving ECM tensile strength + elasticity
b. Describe how collagen fibers are synthesized + where they are most often found in body
i. Understand that diff genes of code for fibrils of diff thickness _ with diff ability to inderact w/ receptors _ glycoproteins
ii. Explain role of force in formation of collagen fibers + fibrils
iii. describe importance of lysin + proline hydroxlyases for collagen formation
c. Describe structure of elastic fibers
(elastin core polymers _ fibrillin microfibril sheath)
i. identify where fibers are most often found in body + why they are important for tissue function
