Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Molecular Exam 2 > Cell Junctions, Adhesion Molecules, and Extracellular Matrix > Flashcards

Cell Junctions, Adhesion Molecules, and Extracellular Matrix Flashcards

1
Q

What are the calcium dependent CAMs?

A

cadherins

selectins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the non calcium dependent CAMs?

A

integrins

immunoglobulin superfamily molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What ligands do cadherins recognize?

A

other cadherins (same or different)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What ligands do selections recognize?

A

carbonhydrates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What ligands do integrins recognize?

A

extracellular matrix molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What ligands do Ig superfamily recognize?

A

integrins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What stable types of junctions do cadherins have?

A

occludens and desmosomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What stable types of junctions do selectins and Ig superfamily have?

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What types of stable type junctions do integrins have?

A

hemidesmosomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Describe classical cadherins

A

major components in calcium mediated adherent junctions

typically form cis and trans homophilic dimers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the three types of classical cadherins?

A

E-cadherins
N-cadherins
P- cadherins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where are e-cadherins found?

A

epithelial tissues and brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Where are n-cadherins found?

A

nerve cells, muscle cells, fibroblasts, lens cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Where are p-cadherins found?

A

placenta and epidermis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Describe non classical cadherins

A

include desmocollins and desmogleins

found in desmosomes (macula adherins)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Extracellular portion contains multiple copies of _______

A

cadherin domain motif

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Intracellular portion of cadherin superfamily are varied, thus able to interact with different _______ and components that anchor the ________ to cytoskeleton

A

intracellular ligands; cadherin; cytoskeleton

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

binding between cadherins is generally _____

A

homophilic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

homophilic binding occurs at the _______ tips of the cadherin molecules

A

n- terminal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Extracellular portion of cadherin consists of several copies fo a motif called a ______

A

cadherin domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

_____ ions bind to sites near each hinge and prevent it from flexing, so cadherin domain is rigid rod

A

Ca2+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

When Ca2+ is removed from a cadherin domain, what happens?

A

hinges can flex, and structure becomes floppy. Conformation at N terminus changes, weakening the binding affinity and disrupting the adhesion
cadherins are then degraded

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Cadherins typically bind to their partners with relatively _____ affinity

A

low

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

In a cadherin mediated adhesion how to strong attachments form?

A

formation of many weak bonds in parallel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is sorting out?
cadherin dependent homophile adhesions mediate highly selective recognition, enabling cells of a similar type to stick together and to stay segregated from other types of cells
26
Appearance and disappearance of cadherins correlate with major _____ in which tissues ______
morphogenetic events, segregate from one another
27
What does the intracellular domain do for cytoskeleton filaments?
provide anchorage
28
What are the most common types of cadherins?
E-cadherins
29
E-cadherins form ______ via a _______
dimers; HVA binding face
30
where are the dimers found on E-cadherins?
tip of extracelluarl end of cadherin molecule
31
What does the loss e-cadherins associate with?
invasive behavior of tumor cells
32
What are catenins?
small portions that link the cytoplasm end of a cadherin with cytoplasmic actin
33
What are the three forms of catenins?
B and y/plakoglobin catenins | a catenins
34
What do B and y/plakoglobin catenins do?
attached to cytoplasmic end of cadherin beta may serve as transcription cofactor beta is attached to alpha catenin
35
What does a catenin do?
binds directly to cytoplasmic actin
36
Selectins bind to _____
carbohydrates
37
Where is the binding site for carbohydrates?
located at the carbohydrate -recognition domain (CRD) at the extracellular end of the selectin
38
Where are calcium binding sites located?
found near CRD and calcium is required for the binding activity
39
Selectins are involved in the ____ of ____ from blood to tissues
movement of leukocytes
40
What are the types of selectins?
P-selectins: associated with platelets E-selectins: associated with endothelial cells L-selectins: associated with leukocytes
41
Integrins are _______ that are mainly involved in _______ interactions
glycoproteins; cell extracellular matrix
42
What do integrins bind to?
extracellular matrix and cytoskeleton
43
What are the two subunits of integrins?
one alpha subunit (17 kinds) | one beta subunit (8 kinds)
44
Integrins interact with ______ sequence in _____ and _____
RGD fibronectin laminin
45
What do the laminin and fibronectin in the basement membrane interact with?
collagen heparan sulfate proteoglycans entactin
46
In hemidesmosomes, integrins link the _____ of cells to the _______ kai the intracellular tonofilaments
basal domain, extracellular matrix
47
What are the members of the Ig superfamily?
N-CAM | I-CAM-1 and I-CAM-2
48
What does N-CAM do?
neural adhesion molecules | mediate both homophilic and heterophilic interactions
49
What does I-CAM-1 do?
facilitates transendothelial migration of leukocytes
50
What are the categories of junctional complexes?
adherens occludens gap junctions
51
What are adherens?
molecular complexes that anchor cells together and reinforce the physical integrity of tissues and the cells that make up the tissues found on the basolateral surface
52
What are occludens?
molecular complexes that establish an impermeable barrier between adjacent cells, prevents paracellular transport and saints concentration differences
53
What are gap junctions?
composed of molecular pores that enable cells to rapidly exchange ions and small molecules that help coordinate activities amounts the cells that make up the tissue
54
What are the two types of junctions?
zonula | macula
55
What are zonula junctions?
either of the adherent or occludens variety travel al the way around the circumference of the cell and link all neighboring cells to the central cell. Belt like associated with intracellular actin
56
What are macula junctions?
spot or snap like junction adherens variety associated with intracellular intermediate filaments
57
What are desmosomes associated with?
lateral domains of epithelial cells
58
What are hemidesmosomes associated with?
basal domains of epithelial cells
59
_______ are anchoring junctions characterized by intercellular spaces which are filled with cadherin proteins: _____ and _______
adherens desmogleins desmocollins
60
Cadherin proteins are anchored to cytoplasmic plaques containing:
desmoplakin | plakoglobin
61
_____ seals gap between epithelial cells
tight junction
62
______ connects actin filament bundle in one cell with hat in the next cell
adherens junctions
63
______ connects intermediate filaments in one cell to those in the next cell
desmosomes
64
_____ allows the passage of small water soluble molecules from cell to cell
gap junction
65
______ anchors intermediate filaments in a cell to extracellular matrix
hemisdesmosomes
66
_______ actin filaments in cell to extracellular matrix
actin linked cell matrix adhesion anchors
67
Zonula adherens are associated with _____
actin microfilaments
68
Macula adherens area associated with ______
intermediate filaments

Molecular Exam 2 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions