Cell-Mediated Immunity Flashcards
(23 cards)
Function of IL-2
-IL-2 stimulates the survival, proliferation and differentiation of antigen-activated T cells
-IL-2 is required for the survival and function of Treg
IL-2 is a growth Hormone-like cytokine
Which CD4 subtype is similar to a CD8
Th1
Which CD4 subtype combats viruses?
Th1
B/c response to intracellular pathogens
Activated by
-IFN-y
-IL-12
Inhibited by
-IL-4
-IL-10
Which subtype of CD4 is activated by cytokines IL-2, and IL-4
Th2
Response to extracellular pathogens
Inhibited by
-IFN-y
IL-4 ____ Th_ and inhibit
Th_.
IFN-y ___ Th_ and inhibit Th_.
IL-4 activated Th2 and inhibit Th1
IFN-y activated Th1 and inhibit Th2
Which subtype of CD4 stays within the lymphoid follicle?
What cytokine activates it and what cytokine inhibits it?
Tfh
Activated by
-IL-6
Inhibited by
-IL-2
Which cytokine activates Treg?
-TGF-beta
-IL-2
Which cytokine is the principal Macrophages-activating cytokine?
IFN-y
What is the principal function of Th1 cells?
To activate macrophages to ingest and destroy microbes
Which CD4 subtype occurs in response to helminths and allergens
Th2
CD4 subtype Th2 uses which antibody as a defense mechanism?
IgG, Eosinophils and mast cells
Th2 is dependent on which cytokine as both an inducer and effector for these cells?
IL-4
-IL-4 activates Th2 (from naive CD4+ cells) and inhibits Th1
-stimulates isotype switching to IgE
-macrophage activation
Which two cytokines work together in defense against helminths and allergic inflammation?
IL-4 + IL-13
By increasing mucus secretion
Which cytokine is an activator of eosinophils?
IL-5
And serves as the principal link between T cell activation and eosinophilic inflammation
Which cells combats microbes by recruiting leukocytes (mainly neutrophils)?
Th17 (subtype of CD4)
Th17 produces IL-22 in epithelial tissues
Th17 produces IL-17 which recruits the neutrophils and stimulates production of anti microbial substances therefore PRO-INFLAMMATORY
CD8 T-cells produce which cytokine?
IFN-Y
Eliminates intracellular microbes, and kills by exocytosis of secretory granules. This is a cause of tissue injury
What are the 2 ways in which helper T cells stimulate CD8+ T cells?
-produce cytokines to stimulate CD8 which are IFN-y and IL-2
-enhance expression of APC costimulators (B7 and CD28) (indirect stimulation)
Which cytokines may be produced by an APC?
-IL-1
-IL-6
-IL-12
Which microbe blocks fusion and thus surviving within a phagocytes? (Inhibition of phagolysosome fusion)
Mycobacterium
Which microbe blocks APC by interfering with the TAP transporter therefore hindering T-cell from acting and engaging?
HSV
Which microbe produces IL-10?
EBV
“SMART MICROBE”
IL-10 inhibition of macrophages and dendritic cell activation
Which microbe inhibits pro-inflammatory cytokines? In other words, inhibition of activating effector cell
Pox virus
Produces soluble cytokine receptors
