Cell-mediated Immunity Flashcards
(27 cards)
Cd marquer on macrophages
CD14
IFN-y activates
Classical M1 macrophages and induces B cells to class switch to produce opsonizing IgG antibodies
Il-2
Most important growth factor for T cells. Stimulates the proliferation of clines of T cells specific to that antigen.
Stages of CTL killing
Attachment
Activation
Exocytosis
Detachment
Valence of IgM
10
Affinity
Binding strength
Avidity
Number of antigen-binding sites available to bind epitopes
Antibody with the highest avidity
IgM
X-linked hyper-IgM syndrome
Elevated levels of IgM
Deficiency of IgG, IgA and IgE
X-linked recessive
Defect in x-linked hyper-IgM syndrome
Defect in the gene encoding CD40 ligand
Function of CD40
Required for the formation of germinal centers Allows class switching
Most abundant antibody found in blood
IgG
IgG subclases
IgG1
IgG2
IgG3
IgG4
Most prevalent IgG antobody found in blood
IgG1
IgG functions
Activates complement
Opsonin
Neutralizes pathogen and toxins
Only antibody able to cross the placenta
Cytokine that drives production of IgA
TGF-B
Function of IgA
Neutralizing antibody
Binds to toxins and pathogens of the mucosa of the digestive, respiratory and urogenital systems
Isotypes of IgA
IgA1 (bloodstream)
IgA2 (mucosal area)
MALT
Mucosal-associated lymphoid tissues
Function of the secretory component
Protects IgA from breakdown
Cytokine that allows class switching to IgE
IL-4 IL-13
Most efficient antibody to activate the complement system
IgM
Näive B-cell antigen receptor
IgM
IgD
INF-y
Activates classical M1 macrophages to eradicate intracellular pathogens and induces B cells to classs switch to produce opsonizing IgG antibodies that can assist the macrophages with phagocytosis
