Cell Signaling

Question 1

How does a GPCR work?

Answer 1

Once a hormone binds to the receptor, the ADP turns into ATP, the alpha subunit can go activate an enzyme which converts ATP to cAMP

Question 2

What happens when cAMP activates PKA?

Answer 2

PKA can go into the nucleus and activate CREB

Question 3

Once CREB is activated and it complexes with CBP, what happens next?

Answer 3

It can activate gene expression, increased gene transcription

Question 4

For RTKs, where is the N and C terminus?

Answer 4

N terminus is on the outside and C terminus is on the inside of the cell and is the catalytic region

Question 5

Once the EGF receptor is dimerized, what happens next? Why?

Answer 5

Autophosphorylation / cross phosphorylation. To open new binding sites

Question 6

What can the insulin receptor influence?

Answer 6

It can signal a specific protein being made, promote or inhibit gene expression. It can also glucose to glycogen. Promote GLUT transports so glucose can enter the cell

Question 7

Once a hormone binds to a nuclear receptor and then it dimerizes, what happens?

Answer 7

The dimer enters the nucleus and binds to a specific sequence to promote or inhibit a specific protein

Question 8

Why are hormone nuclear receptors good targets for drugs?

Answer 8

I can inhibit protein synthesis or block other proteins from binding