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Medicine Unit 1 > Cell structure > Flashcards

Cell structure Flashcards

1
Q

what are the seven pillars of life

A

a programme
improvisation
compartmentation
energy
regeneration
adaptability
seclusion

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2
Q

a programme

A

organised plan for constitution and regeneration; DNA

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3
Q

improvisation

A

changing the program as surroundings change; evolution

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4
Q

compartmentation

A

ability to be separate from environment; membranes

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5
Q

energy

A

ability to maintain order despite overall positive entropy

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6
Q

regeneration

A

compensation for environmental wear and tear; repair

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7
Q

adaptability

A

ability to respond to environmental changes

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8
Q

seclusion

A

operation of processes and pathways in isolation

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9
Q

ribosome function

A

protein synthesis

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10
Q

peroxisome function

A

oxides fatty acids

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11
Q

cytoskeleton function

A

supports cell, aids in movement of organelles

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12
Q

lysosome function

A

degrees intracellular debris

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13
Q

transport vesicle function

A

shuttles lipids and proteins between the ER, Golgi and plasma membrane

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14
Q

Golgi function

A

processes, packages and targets proteins to other organelles or for export

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15
Q

smooth endoplasmic reticulum function

A

site of lipid synthesis and drug metabolism

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16
Q

nucleus function

A

contains the genes (chromatin)

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17
Q

nucleolus function

A

site of ribosomal RNA synthesis

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18
Q

rough endoplasmic reticulum function

A

site of protein synthesis

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19
Q

mitochondria function

A

oxidation of fuels to produce ATP

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20
Q

nuclear envelope function

A

segregates chromatin (DNA + protein) from the cytoplasm

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21
Q

plasma membrane function

A

separates cell from environment, regulates movement of materials into and out of the cell

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22
Q

examples of supramolecular complexes

A

chromatin
plasma membrane
cell wall

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23
Q

examples of macromolecules

A

DNA
protein
cellulose

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24
Q

examples of monomeric units

A

nucleotides
amino acids
sugars

25
Q

which elements do 99% of biological compounds contain

A

C,H,O,N,P,Ca,S

26
Q

what are the four major classes of biomolecules

A

carbohydrates
amino acids
nucleotides
lipids

27
Q

carbohydrates

A

glucose, fructose, sucrose
mainly used as sources of cellular energy

28
Q

amino acids

A

20 natural amino acids in total
used as protein monomers

29
Q

nucleotides

A

5 different types in total
used as parts of DNA and RNA precursors

30
Q

lipids

A

known as fats
not very water soluble
used as sources of cellular energy
components of cell membranes

31
Q

vitamins

A

organic compounds necessary for proper growth and development

32
Q

heme

A

organometallic compound containing iron
important for transporting oxygen in your blood stream

33
Q

how do enzymes accelerate and control the rates of reaction

A

greater reaction specificity
milder reaction conditions
capacity for regulation

34
Q

how are enzymes the agents of metabolic function

A

metabolites have many potential pathways
enzymes make the desired one the most favourable

35
Q

cytoplasm

A

highly viscous solution
many reactions occur

36
Q

cytoskeleton

A

contains microtubules
actin filament and intermediate filaments
- cellular shape and division
- intracellular organisation
-intracellular transport paths
-cellular mobility

37
Q

actin filaments

A

involved in generating contractile forces
found beneath the plasma membrane
actin rearrangement (polymerisation and depolymerisation) allows the cells to move forwards

38
Q

microtubules

A

form the mitotic spindle for the separation of the duplicated chromosomes during mitosis

39
Q

rapid changes in the actin cytoskeleton allows what

A

cells to change orientation and direction

40
Q

phospholipid bilayer

A

bilayer allows semi-permeability
contains membrane proteins with various functions

41
Q

name some things located on the plasma membrane

A

globular proteins
glycoproteins
carbohydrate sugar chain
cholesterol
hydrophilic heads of the phospholipids
hydrophobic tails of the phospholipids
peripheral membrane proteins
integral membrane proteins
cell membrane receptor proteins

42
Q

the 6 cell membrane roles

A

transport
enzymatic activity
signal transduction
cell-cell recognition
intercellular joining
attachment

43
Q

transport

A

controls entry and exit of materials through carrier and channel proteins

44
Q

enzymatic activity

A

enzymes break down macromolecules

45
Q

signal transduction

A

send and receive information through ligands and receptors

46
Q

cell-cell recognition

A

recognise other cells and pathogens through recognition receptors

47
Q

intracellular joining

A

cells are joined to one another through adhesion proteins

48
Q

attachment

A

cells are bound to the extracellular matrix by integrin proteins

49
Q

protein synthesis and sorting

A

ribosomes are the cells protein making machines
in order for proteins to be functional they need to be transported to their site
this is protein sorting
the localisation of a synthesised protein depends on whether it has a sorting signal
proteins without a sorting signal remain in the cytosol
proteins destined for other organelles including the plasma membrane enter the ER as they’re being synthesised
from the ER proteins are then transported to the Golgi
proteins are then enclosed in transport vesicles to be delivered to their final destination

50
Q

quality control of proteins and diseases

A

proteins are synthesised as chains of amino acids
by coiling and folding into a specific three dimensional shape they can perform their biological function
this involves the formation of disulphide bonds catalysed by enzymes residing in the ER
improper folding can have severe consequences for the cell
incorrectly folded proteins exit the ER and are exported to the proteasome for degradation

51
Q

quality control of low density lipoprotein

A

their receptors are required for the uptake of cholesterol
mutations of the LDLR cause it to be misfolded and degraded
cystic fibrosis transmembrane conductance regulator CFTR moves acts as a channel for chloride ions
mutant protein retains functionality but it is still recognises as misfolded and is degraded

52
Q

degradation

A

cells not only have to synthesise macromolecules but they need to eliminate cellular waste
cellular waste can be in the form of membrane bound signalling proteins which if not removed can signal the cell to divide continually
cells also take up macromolecules such as cholesterol to avoid its excessive build up
cells also degrade unwanted or worn out organelles and macromolecules
specialised immune cells engulf microorganisms and eliminate dying cells
they’re handled by lysosomes through the process of endocytosis

53
Q

cell endocytose material from the plasma membrane

A

part of the plasma membrane invaginate enclosing the material then pinches off to form endocytic vesicles
endocytic vesicles fuse with early endoscopes, cargo destined for degradation is retained and incorporated into late endosomes
late endosomes fuse with the lysosomes to deliver cargo for degradation

54
Q

receptor mediated endocytosis

A

macromolecules such as glucose, LDL, transferrin (collectively known as ligands) bind to their corresponding plasma membrane receptors
ligand bound receptors clusters on the membrane which invaginate and forms the endocytic vesicles
because the ligand-receptor interaction is very selective it allows the cells to be selective in the materials to internalises

55
Q

mitochondria supplies energy for cell survival

A

most of cellular functions that require energy occur in the cytoplasm
however the process of harnessing energy takes place in the mitochondria
energy needs to be transferable and as such cells store energy in the bonds of ATP
mitochondria absorb short carbon chains and oxygen to generate carbon dioxide and ATP
ATP is used to power protein synthesis, transport of molecules against their concentration gradient, muscle contraction, cellular movements

56
Q

mitochondria can also drive cell death

A

apoptosis
mitochondria contain cytochrome c
when cells sense damage or any abnormality they activate proteins which form channels in the mitochondrial membrane
through these channels cytochrome c is released which then cause the activation of caspases and subsequently induce apoptosis

57
Q

nucleus serves as the control centre for cellular functions

A

houses DNA to code for amino acids to make proteins
DNA controls protein synthesis in essence so therefore cell structure and cell function
fundamental function of the cell is to replicate itself in order to maintain cell populations and ensure tissue homeostasis
requires it to copy its DNA and other cellular components and equally divide into two daughter cells through the cell cycle

58
Q

cell cycle and mitosis

A

interphase:
- cellular components are replicated
- G1 and G2 cell duplicates specific molecules and structures
- S cell replicates DNA
mitosis:
-interphase: chromosomes are uncondensed
-prophase: spindle condenses, centrioles appear and the nuclear envelope breaks down
-metaphase: chromosomes align
-anaphase: centromeres and chromatids part
-telophase: spindle disassembles and nuclear envelope reforms

forms two identical diploid daughter cells

Medicine Unit 1 (8 decks)

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