Cell wall inhibitors: Vancomycin

Question 1

Vancomycin

Answer 1

• **Bacteriocidal **
• **G+ ONLY **
• cell wall synthesis inhibitor = peptidoglycan synthesis by binding D-ala D-ala inhibiting polymerization
• IV (PO for C diff)
• **renal excretion **
• adverse effects:
  
  • **thrombophlebitis **
  • **ototoxicity **
  • flushing
  • **nephrotoxicity **
• resistance = D-ala to D-lactate (reduced affinity for vanc)