Cell Wall Or Cell Membrane Disruption

Question 1

What is the mechanism of action for Penicillins?

Answer 1

Bactericidal; binds to penicillin-binding proteins leading to cell wall synthesis disruption

Question 2

What is Penicillin G used for?

Answer 2

Narrow spectrum antibiotic used for infections like meningitis, endocarditis, and syphilis

Question 3

What are the allergic reactions associated with Penicillins?

Answer 3

Hypersensitivity reactions, ranging from rash to anaphylaxis

Question 4

What is Penicillin V primarily used to treat?

Answer 4

Oropharyngeal infections

Question 5

What spectrum of bacteria does Amoxicillin cover?

Answer 5

Gram-positive cocci, some Enterococcus, and some gram-negative bacilli

Question 6

Which conditions are Aminopenicillins without beta-lactamase inhibitors used for?

Answer 6

Ear, sinus, and respiratory tract infections

Question 7

What is the main side effect of Aminopenicillins with beta-lactamase inhibitors?

Answer 7

Diarrhea

Question 8

What is the clinical use of first-generation Cephalosporins like Cefazolin?

Answer 8

Surgical prophylaxis and skin infections

Question 9

For what reason might Cephalosporins cause a cross-reactivity in patients allergic to Penicillins?

Answer 9

Due to the similar beta-lactam structure

Question 10

Which Cephalosporin is used for gonorrhea and has the acronym ‘FIX’?

Answer 10

Cefixime