Cells, ions, n shit Flashcards

(86 cards)

1
Q

Carbohydrates) classes
F:

A

= Mono-, Di-, Poly-saccharides
= Structure & Source of energy

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2
Q

Intercalated discs:

Discs speed Vs standard cell membrane:
Syncytium:

A

= (only heart) Special tissue bands inbetween myocardial cells increase AP cell spread rate(400x) for thus Syncytium
= 400x faster than standard cell membrane drom/Inotropy
= Group of cardiac cells physiologically function as a unit, “working together in sync” “top in syncytium to bottom”

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3
Q

1Hemostasis:
2Inflammation:
3Epithelialization:
4Neovascular:
5Collagen synthesis:

A

1= vaso/strict, platelet aggregate, coagulation fibrin (normothermic)
2= Granulocytes, macrophages & Lymphocytes eat, Mast cells released
3= “rebuild” epithelial cells go to wound making scab ~48Hrs after cut
4= new capillaries made (neo new) via previous cap/s +exchanging
5 = fibroblasts go to wound & synthesize collagen creating scar (w/ tension lines quicker/better), Too much synthetization makes Keloid

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4
Q

Epithelialization of skin healing process

A

= “rebuilding” epithelial cells go to wound making scab ~48Hrs from initial exposure

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5
Q

Collagen synthesis of skin healing process

A

= fibroblasts go to wound & synthesize collagen creating scar (w/ tension lines quicker/better), Too much synthetization makes Keloid

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6
Q

cells sent with Inflammation stage of soft tissue healing

A

Granulocytes, macrophages & Lymphocytes eat & Mast cells released

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7
Q

phagocytosis:

A

macrophages eats & grows bad bacteria then grow a flag to show what antibodies to make for cellular response

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8
Q

Blood:
Plasma:
Leukocytes:
Erythrocytes:

A

= Mixture of water, cells, proteins, & suspended elements.
= makes up 55% of the blood volume
= WBC & platelets make up the “Buffy Coat”
= RBC make up 45%

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9
Q

Platelet Phase of hemostasis:

A

2nd phase, Platelets aggregate, or collect and adhere. Slows hemorrhage from capillaries and small vessels- splint fractures to decrease of clots being broken down & bleeding again

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10
Q

Coagulation Phase of hemostasis:

A

3rd phase Clotting factors activated and released into bloodstream through a very complex cascade of events Triggers series of chemical reactions; formation of strong protein fibers (fibrin)

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11
Q

Blood-Brain Barrier) built so:

Prevents & Protects:

A

= CNS capillary walls thicker, more complete, not as permeable as elsewhere in body.
= Doesn’t permit interstitial flow of proteins & materials as freely as normal capillaries, Protects w/ need lipid loving to get through, anything that can get through can cause damage

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12
Q

Baroreceptors) Fn:
A&P:

A

= receptors that monitor blood pressure
= Great vessels recept/ Gives feedback to brain > Sympathetic NS Activation, AArch & carotid arteries> feedback to medulla >SNS

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13
Q

CNS blood supply) 1 Brain’s % of body weight & uses for ATP
2 Brains Oxy & glucose consumption:
Brain is supplied by:

A

1= 2% }Uses lots of blood & oxy, can only use glucose for ATP
2= Consumes 25% of body’s glucose & 20% of oxygen supply
3= Circle of Willis} Carotid system (anterior) & Vertebrobasilar system (posterior)

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14
Q

Most prevalent intracellular Ion=
Most prevalent extracellular ion=

A

Potassium
Sodium

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15
Q

Hyperkalemia affects leads to=

A

messed up cell membranes leaking out of cells

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16
Q

Bone Cells

A

Osteoblasts, Osteocytes, Osteoclasts,

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17
Q

Osteoblasts:

A

= Promote bone repair after fractures by producing bone matrix; important in PTs w/ broken bones.

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18
Q

Osteoprogenitor Cells:

A

bone Stem cells that differentiate into osteoblasts, aiding in bone repair post-fracture; important in bone repair from bone trauma

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19
Q

Osteocytes:

A

Help maintain bone structure & strength; crucial for understanding PTs w/ bone diseases like osteoporosis.

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20
Q

Osteoclasts:

Osteoclast disorders:

A

Resorb bone to regulate Ca+ levels, critical in PTs w/ metabolic bone disorders or Ca imbalances
= Osteoporosis & Osteopenia

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21
Q

Chondrocytes:

A

Maintain cartilage

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22
Q

Blood Cells:

A

= RBC (Erythrocytes), WBC (Leukocytes), platelets (Thrombocytes)

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22
Q

Erythrocytes F:

A

RBC Transport O2; critical in hypoxia or hemorrhage management.

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23
Q

Leukocytes

A

WBC Fight infections; increased & sent to areas of sepsis or infection.

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24
Thrombocytes
= Platelets Facilitate clotting; essential in hemostasis
25
Immune Cells & Processes
Mast Cells, Macrophages, IgE (Immunoglobulin E), phagocytosis
26
Mast Cells:
Release histamine & other chemicals during inflammatory responses; overactivation causes allergies or anaphylaxis, underactivity impairs inflammation.
27
Macrophages:
Perform phagocytosis; critical in infection control & tissue repair.
28
IgE (Immunoglobulin E):
Triggers mast cell activation in anaphylaxis, managed w/ epinephrine
29
Phagocytosis:
Process where cells like macrophages & neutrophils engulf pathogens; defective phagocytosis leads to persistent infections.
30
Neurons:
Transmit signals via action potentials; damage results in sensory or motor deficits.
31
Keratinocytes:
Produce keratin to protect skin; overproduction causes thickened skin (psoriasis), underproduction increases vulnerability to injury.
32
Alveolar Cells:
Type I facilitate gas exchange, Type II produce surfactant to reduce alveolar collapse; dysfunction leads to respiratory distress.
33
Endocrine Cells
Beta Cells (Pancreas), Alpha Cells (Pancreas), Chromaffin Cells (Adrenal Medulla)
34
Endocrine Beta Cells (Pancreas):
Secrete insulin to regulate blood glucose; destruction causes diabetes mellitus.
35
Endocrine Alpha Cells (Pancreas):
Produce glucagon to increase blood glucose; overproduction results in hyperglycemia, underproduction causes hypoglycemia.
36
Endocrine Chromaffin Cells (Adrenal Medulla):
Release epinephrine & norepinephrine; overactivity leads to hypertension (pheochromocytoma), underactivity reduces stress response.
36
Chondrocytes:
Maintain cartilage matrix by producing collagen & proteoglycans; critical in joint cushioning & growth plates.
37
Blood's Leukocytes:
Neutrophils, Eosinophils, Lymphocytes, Monocytes
38
Neutrophils:
= First responders in bacterial infection; phagocytose pathogens & release reactive oxygen species (ROS).
39
Eosinophils
Combat parasitic infections; involved in allergic reactions by releasing histamine. Basophils: Release histamine & heparin to mediate inflammation.
40
Monocytes
Differentiate into macrophages or dendritic cells; phagocytose pathogens & present antigens.
40
Lymphocytes
Include B cells (antibody production), T cells (cytotoxic & helper roles), & natural killer (NK) cells for tumor/virus destruction.
41
Muscle Tissue) cells
Skeletal Myocytes, Cardiac Autorhythmic & Contractile Myocyes, Smooth Myocytes
42
Muscle Tissue) Skeletal Myocytes:
Long, multinucleated cells w/ striations; enable voluntary movement via sliding filament mechanism (actin-myosin).
43
Muscle Tissue)Cardiac Myocytes types
Autorhythmic, Contractile & Smooth Myocytes
44
Cardiac Muscle T.) Autorhythmic Cells: Contractile Cells:
=Generate & conduct electrical impulses; include SA & AV node cells for heart rhythm control. = Perform mechanical contraction, ejecting blood during systole.
45
Nervous system) major components
= Neurons, Neurotransmitters, Glial cells,
45
Muscle Tissue) Smooth Myocytes
= Non-striated cells in visceral organs; control involuntary processes like peristalsis & vasoconstriction.
46
Nervous System) Neurons
= Specialized for signal transmission; sensory (afferent), motor (efferent), & interneurons.
46
Nervous System) Neurotransmitters
Acetylcholine (ACh), Dopamine, Serotonin, Glutamate, GABA
47
NS Neurotransmitters) Acetylcholine (ACh): Dopamine: Serotonin:
= Excitatory in skeletal muscles; inhibitory in cardiac muscle. = Modulates motor control, mood, & reward pathways. = Regulates mood, sleep, & gut motility.
48
Nervous system) Afferent neurons Efferent neurons Interneurons
= sensory transmit stimuli from body to CNS. = Motor Transmit signals from CNS to muscles & glands. = Facilitate communication between sensory & motor neurons in the CNS
49
NS Neurotransmitters) Glutamate: GABA:
= Main excitatory neurotransmitter in CNS. = Primary inhibitory neurotransmitter in CNS.
50
Nervous System) Glial cells
Astrocytes, Oligodendrocytes, Microglia, Schwann Cells:
51
NS Glial cells) Astrocytes: Microglia: Oligodendrocytes: Schwann Cells:
= Regulate blood-brain barrier & nutrient supply = Immune defense in CNS. = Myelinate CNS axons. = Myelinate PNS axons.
52
Endocrine/Hormones System) Glucagon: Insulin: Cortisol
: Secreted by alpha cells of pancreas; increases BG by stimulating glycogenolysis & gluconeogenesis. Binds to receptors on liver, adipose tissue, & heart (reg/s CO). = Secreted by beta cells; lowers BG by enhancing cellular uptake & glycogenesis.
53
Endocrine/hormone) Cortisol Epinephrine
= Stress hormone from adrenal cortex; promotes gluconeogenesis & anti-inflammatory effects. = Adrenal medulla hormone; increases HR, cardiac output, & bronchodilation during stress.
54
Endocrine/hormone) Parathyroid Hormone (PTH): Thyroid Hormones (T3/T4):
= Increases blood Ca+ by stimulating bone resorption & renal reabsorption. = Regulate metabolism, growth, & development.
55
Respiratory System) cells
= Alveolar Type I & 2, Ciliated Epithelial Cells, Goblet Cells
56
Respiratory System) Alveolar Type I Cells: Alveolar Type II Cells:
= Thin squamous cells forming the majority of alveolar surface; essential for gas exchange. = Produce surfactant to reduce surface tension & prevent alveolar collapse.
56
Cartilage) Chondroblasts: Chondrocytes
= "build" Extracellular matrix (ECM) = "keep" maintain ECM
57
Respiratory system) Ciliated Epithelial Cells: Goblet Cells:
= Line airways; move mucus & trapped debris out of respiratory tract. = Produce mucus to trap particles & protect airway lining.
58
Skin) Carotene
yellow/orange pigment: is converted to vitamin A & facilitates vision & immune system
59
Skeletal) Fibroblasts
= Secrete extracellular matrix proteins (e.g., collagen & elastin) in cartilage & ligaments.
60
Muscle) Satellite Cells
= Muscle stem cells located on the surface of skeletal muscle fibers; repair & regenerate damaged muscle.
61
Skin Integumentary System) cells
= Keratinocytes, Melanocytes, Langerhans Cells, Merkel "tactile" Cells
62
Skin Integumentary System) Keratinocytes Melanocytes Langerhans Cells Merkel "tactile" Cells:
= Produce keratin for protective barrier (nails, palms, soles) = Produce melanin for UV protection. = Detect pathogens & trigger immune responses. = Detect fine touch & pressure stimuli.
63
Endothelial Cells:
Line blood vessels; regulate vascular tone, permeability, & clotting.
64
Mesothelial Cells: Pancreatic Acinar Cells:
= Line body cavities (pleura, peritoneum); secrete lubricating fluid. = Secrete digestive enzymes (e.g., amylase, lipase) into the duodenum
65
Enzymes) common function
Enzymes are biological catalysts that accelerate chemical reactions.
66
Enzymes) ATP Synthase: Carbonic Anhydrase:
= Produces ATP using proton gradient in mitochondria. = Catalyzes reversible conversion of CO2 & water to carbonic acid (critical in acid-base balance).
67
Enzymes) Amylase: Lipase:
= Breaks down carbohydrates (starches) into simpler sugars (e.g., maltose); found in saliva & pancreas. = Hydrolyzes lipids into glycerol & fatty acids; secreted by the pancreas.
68
Proteins) common functions
= Proteins serve structural, functional, & regulatory roles
69
Proteins) blood) Hemoglobin: Albumin: Fibrin: Immunoglobulins (Antibodies): Produced by plasma cells; recognize & neutralize antigens.
= Binds O2 in red blood cells; facilitates O2 & CO2 transport. = Maintains oncotic pressure in blood plasma; binds & transports substances like fatty acids & hormones. = Stabilizes blood clots by forming an insoluble network of fibers.
70
Proteins) skeletal) Collagen: Elastin:
= Provides structural integrity in connective tissues (EX skin, tendons, & bones). = Provides elasticity to tissues like skin & blood vessels.
71
Proteins) Keratin:
= Structural protein in hair, nails, & skin.
72
Proteins) Actin & Myosin
Essential for muscle contraction & cellular movement.
73
Carbohydrates) Monosaccharides: Disaccharides: Polysaccharides:
}simple sugars: Glucose, Ribose, Deoxyribose } Sucrose = Glucose + fructose } Glycogen, Starch, Cellulose
74
Cations
(Positive Ions) Sodium (Na+), Potassium (K+), Calcium (Ca+), Magnesium (Mg2+), Hydrogen (H+)
75
Cations) Sodium (Na+): Potassium (K+): Calcium (Ca+):
= Maintains osmotic balance; generates action potentials via voltage-gated channels. = Regulates resting membrane potential; involved in muscle contraction & nerve conduction. = Essential for muscle contraction, neurotransmitter release, & bone structure.
76
Cations) Magnesium (Mg2+): Hydrogen (H+):
= Cofactor for ATP-dependent reactions; stabilizes DNA & RNA. = Determines pH; regulated by buffers, lungs, & kidneys.
77
Anions)
= Neg/ Ions) Chloride (Cl-), Bicarbonate (HCO3-), Phosphate (PO4³-)
78
Anions) Chloride (Cl-) Bicarbonate (HCO3-), Phosphate (PO4³-)
= Maintains osmotic pressure & electrical neutrality; major component of gastric acid (HCl). = Buffer in blood; regulates acid-base balance. = Component of ATP, DNA, & cell membranes; vital for energy transfer.
79
Renal System) cells, Principal Cells,
= Podocytes, Juxtaglomerular Cells, Principal Cells
80
Renal system) Podocytes: Juxtaglomerular Cells: Principal Cells:
= Form filtration slits to allow selective filtration of blood. = Secrete renin to reg/ BP & Na balance. = in collecting ducts; reg water & Na+ reabsorption via ADH & aldosterone.