Cells & Tissues Lecture 2 Flashcards
Arrangement of epithelium cells?
Continuous sheets, single or multiple layers
Epithelium cells are held together by?
Cell junctions = tight junctions, adherens junctions, desmosome, gap functions (lateral), hemidesmosome (basal)
Function of epithelial tissues?
Secretory (free surface), protection (abrasion), selective barrier (limit or aid transfer)
Draw tight junction and label
Pic
Draw adherens junction and label
Pic
Draw gap junction and label
Pic
Draw desmosome and label
Pic
Draw hemidesmosome and label
Pic
Cytoskeleton makeup?
Microfilaments - ACTIN -bundles beneath cell membrane and cytoplasm; strength, alter cell shape; link cytoplasm to membrane; tie cells together; muscle contraction
Intermediate filaments - KERATIN -Cytoskeleton strength; may move some materials through cytoplasm
Junctional complex?
Tight junction + adherens junction + desmosome
Basement membrane is made up of two things?
Basal lamina (just underneath the cells) secreted by the epithelial cells containing collagen, laminin, other proteoglycans, glycoproteins Reticular lamina (underneath the basal lamina) produced by cells of the underlying connective tissue known as fibroblasts containing fibrous proteins such as fibronectin, collagen
Epithelium contain _ but not _?
Nerves, blood vessels (avascular)
Where does diffusion of nutrients and waste take place?
From the blood vessels in the connective tissue
What are the functions of the basal membrane?
Supports overlying epithelium, provides a surface where epithelial cells migrate during growth and wound healing, acts as a physical barrier
Melanoma stages…?
A = asymmetry B = blood irregularity (rough edges) C = colour D = diameter > 6mm