Cellular immune response 1

Question 1

What cells lead the cellular immune response?

Answer 1

T lymphocytes

Question 2

How are initiator caspases activated?

Answer 2

multi molecular death complexes

Question 3

What is the action of effector caspases?

Answer 3

break down cellular structure

Question 4

How are infmallatory caspases activated?

Answer 4

multi molecular inflammasomes

Question 5

Describe cytotoxic T cell lethal hit (intrinsic apoptosis pathway)

Answer 5

Granzymes from T cell into target cell, mitochondria of target cell produce cytochrome C, caspase-3 is produced, DNA fragments, apoptosis occurs

Question 6

Describe cytotoxic T cell CD95L (extrinsic apoptosis pathway)

Answer 6

Ligation of CD95 death receptors, death inducing signaling complex (DISC), DNA fragments, apoptosis

Question 7

What are the main targets of cytotoxic T cells?

Answer 7

virus/ tumor infected cells

Question 8

What is released by different cells to activate macrophages?

Answer 8

IFN-y (NK cells) innate

IL-2 (Th1 cells) adaptive

Question 9

What is the role of M1 and M2 activated macrophages?

Answer 9

M1: inflammation
M2: resolution of inflammation, cell proliferation, angiogenesis

Question 10

What is a CD44+ cell?

Answer 10

Effector memory T cell