Cellular Injury

Question 1

what is the equation for O2 content?

Answer 1

O2 content= (Hb g/dL x 1.34) x SaO2+PaO2x0.003

Question 2

what value is low in hypoxemia?

Answer 2

PaO2

Question 3

what is wrong in a ventilation defect?

Answer 3

the lung is perfused, but there isn’t adequate ventilation

Question 4

what’s wrong in methemoglobinemia?

Answer 4

heme Fe3+, can’t bind O2

Question 5

what is the cause of MetHb?

Answer 5

oxidant stress (drugs, sepsis)

Question 6

what happens to PaO2 and SaO2 in MetHb?

what happens to oxygen binding curve?

Answer 6

normal PaO2, decreased SaO2

left shift

Question 7

what is the Tx for MetHb?

Answer 7

IV methylene blue, accelerates methemoglobin reductase

Question 8

decreases SaO2, normal PaO2, lactic acidosis

Answer 8

CO poisoning

Question 9

Tx CO poisoning

Answer 9

100% O2 via nonrebreather mask/endotracheal tube

Question 10

function of 2,3 BPG

Answer 10

stabilizes taut form of Hb

Question 11

causes of left shifted oxygen binding curve

Answer 11

decreased 2,3 BPG
CO
alkalosis
metHb
fetal Hb
hypothermia

Question 12

causes of right shifted OBC

Answer 12

high altitude
fever
acidosis
high 2, 3BPG

Question 13

at high altitude, what will be the values for CO2, 2,3BPG, and the OBC?

Answer 13

right shift OBC
low CO2 due to hyperventilation
high 2,3-BPG

Question 14

effects of CO and CN on ETC

Answer 14

inhibit cytochrome oxidase, preventing the consumption of O2

this prevents O2 from diffusing from blood to tissue