Cellular Response to CNS Trauma Flashcards Preview

Neuro Week 1 > Cellular Response to CNS Trauma > Flashcards

Flashcards in Cellular Response to CNS Trauma Deck (14):
1

What cell of the CNS reacts most to trauma?


astrocytes

2

What is the neuron's response to acute injury, typically blood loss?How about chronic issues?


acute injury - red neurons

chronic injury - "degeneration" - really just drop out

3

What is an axonal reaction?


It's what happens to the cell body when an axon is severed - it basically just gets huge.

4


What are axonal spheroids and when do they occur?

These are spheridcal balls of protein that form within the axon itself - triggered by injury, but also just normal aging

5


What inclusion bodies will you see in herpes infections?


Cowdry bodies

6


What inclusion bodies will you see in a rabies infection?


negri bodies

7

What is the neurofibrillary tangle made of in AD?


tau protein

8

What are the 4 general reactions of astrocytes to injury?


gliosis

gemistocytic astrcytes

cytoplasmic swelling

inclusion bodies

9

What is gliosis?


It's proliferation of the astrocytes - trying to reform the general structure of the brain

10

What is gemistocytosis?


WHen the astrocytes send off really thick processes and look kinda big and juicy

11

What inclusion body might you see in an astrocyte post trauma?


Rosenthal Fibers

12

What is corpora amylacea?


It's changes in the astrocyte such that it's bigger, rounder- almost like a pearl. It's a degenerative change you'll see in aging - doesn't really mean anything

13

How will microglia react to trauma like an infection or foreign body?


they'll proliferate and form a microglial nodule around the invader

14