Centrally Acting Muscle Relaxants - Kinder

Question 1

central acting spasmolytics

Answer 1

baclofen
tizanidine
diazepam

Question 2

local muscle spasm drugs

Answer 2

carisopridol

cyclobenzaprine

Question 3

non-central acting spasmolytics

Answer 3

dantrolene

botulinum toxins

Question 4

spasticity

Answer 4

increase tonic stretch reflex - flexor muscle spasms

hyperexcitable alpha motor neurons

therapy - modify stretch reflex arc

Ia fibers

Question 5

baclofen MOA

Answer 5

agonist at GABA-B receptors

hyperpolarization results

Question 6

neurokinin 1

Answer 6

substance P

Question 7

tizanidine MOA

Answer 7

alpha2 agonist - reinforce presynpatic and postsynaptic inhibition in cord

Question 8

diazepam MOA

Answer 8

promote GABA binding to GABA-A receptors

Question 9

carisoprodol MOA

Answer 9

CNS depressant

tx local muscle spasm

Question 10

carisoprodol DR

Answer 10

drowsy and dizzy

-addictive

Question 11

cyclobenzaprine MOA

Answer 11

unclear

-reduced somatic motor active influence both alpha and gamma motor neurons

Question 12

inhibit RyR channels

Answer 12

dantrolene

Question 13

malignant hyperthermia Tx

Answer 13

dantrolene

Question 14

MOA botulinum

Answer 14

zinc endopeptidase cleaves vesicle fusion proteins

-prevent release of ACh

Question 15

MOA interferons

Answer 15

enhanced suppressor T cell activity

• reduce proinflammatory cytokines
• downregulate Ag presentation
• reduce lymphocytes to CNS

Question 16

MOA glatiramer acetate

Answer 16

random polymers of 4 AAs - Ala, Glu acid, Lys, Tyr

similar to myelin basic protein

induce activate T lympho suppressor function

interfere with antigen-presenting function of certain immune cells opposing pathogenic T cell function

Question 17

MOA mitoxantrone

Answer 17

intercalates into DNA - cross link and strand breaks

for rapidly advancing MS that has failed other therapy

Question 18

glucocorticoids in MS

Answer 18

tx primary and seoncdary progressive MS

alone or combo with other immunomodulators