Cephalosporins

Question 1

MoA

Answer 1

Interferes with bacterial cell wall synthesis
Similar spectrum of activity to penicillin’s
Broad spectrum
Bactericidal

Question 2

Use

Answer 2

UTI (pregnancy or second line)
Sinusitis
Otitis media

Question 3

1st generation - CEFA

Answer 3

Cefalexin
Cefradine

Question 4

2nd generation

Answer 4

Cefuroxime
Cefaclor (protractd skin reactions, especially in children)

Question 5

3rd generation (parenteral)

Answer 5

Cefixime (orally active)
Ceftriaxone (OD, meningitis)
Cefotaxime (meningitis)

Question 6

5th generation (parenteral)

Answer 6

Ceftaroline
- CAP
- Complicated skin and soft tissue reactions

Question 7

SE

Answer 7

Hypersensitivity
- Do not give in history of immediate penicillin hypersensitivity
- If no alternative and essential, give 3rd gen or cefuroxime

Abx associated colitis
- More common in 2nd and 3rd gen cephalosporins