Cerebellum Flashcards
(41 cards)
What are the motor functions of vermis? non-motor?
motor- balance, eye movements, reflexes
nonmotor- autonomic arousal, limbic regulation
What are the motor functions of paravermis? nonmotor?
motor- sensorimotor integration, movement execution
nonmotor- simple verbal response to commands
What are the motor functions of lateral hemisphere (includes dentate nucleus)? nonmotor?
motor- prep and planning of eye movements, fine motor dexterity, imagined movements
nonmotor- verbal association, rule-based learning, working memory, problem solving, monitoring performance, temporal perception
What are the names for these regions- vermis, floculus/nodulus, lateral hemisphere- based on source of strongest input?
vermis- spinocerebellum
flocculus/nodulus- vestibulocerebellum
lateral- cerebrocerebellum
What are the 3 basic elements that compose the cerebellum?
cerebellar cortex, deep cerebellar nuclei, large white matter tracts
What are the 6 neuron types in cerebellar cortex?
granule, golgi, purkinje, stellate, basket, lugaro
What are the 2 neurons in deep cerebellar nuclei?
projection neurons, interneurons
What are the 3 layers of cerebellar cortex?
molecular layer, Purkinje cell layer, granule cell layer
What do Purkinje cells project to? Is it inhibitory or excitatory synapse?
deep output nuclei, inhibitory
What synapses on granule cells? Say where they are from and whether it is excitatory or inhibitory.
mossy fibers from pontine nuclei- excitatory
mossy fibers from RF, vestibular nuclei, spinal cord- excitatory
NE, DA, 5HT, ACh- excitatory
golgi cells- inhibitory
What synapses on Purkinje cells?
climbing fibers from inferior olive- excitatory
parallel fibers from granule cells- excitatory
What does the deep output nuclei project to? (3) tell whether excitatory or inhibitory.
VA/VL of thalamus- excitatory
inferior olive- inhibitory
red nucleus magnocellular path (rubrospinal tract)
What projects to the deep output nuclei?
purkinje cell- inhibitory
inferior olive- excitatory
Trace the path from purkinje cells to cortex.
Purkinje cell inhibits deep nuclei, which powerfully activate the thalamus and motor cortex
What are the AP types for purkinje cells?
simple spike and complex spike
What input to Purkinje cells cause simple spikes? Describe simple spikes.
parallel fibers from granule cell, predictable APs in response to specific aspects of movement
What do simple spikes reflect?
moment to moment changes in behavior
What is the efference copy?
copy of commands for movement
What is the reafference copy?
expected sensory info coming back from body part being used
Where does the dorsal spinocerebellar tract arise from and what info does it carry?
from clarke’s nucleus, carries reafference info from lower limbs
Where does the ventral spinocerebellar tract arise from and what info does it carry?
from the ventral horn, efference copy for lower limbs
Where does the cuneocerebellar tract arise from and what info does it carry?
from the accessory cuneate nucleus, carries reafferance info from upper limbs
Where does the rostral spinocerebellar tract arise from and what info does it carry?
from the ventral horn, efference copy for the upper limbs
What input to Purkinje cells causes complex spikes? Describe complex spikes.
climbing fibers from inferior olive, single AP in IO causes long lasting purkinje cell depolarization resulting in 5 APs and causes Purkinje cell to be refractory to parallel fiber activation during it and in afterhyperpolariation after it occurs
