Cerebral Physiology

Question 1

Metabolic rate of braine

Answer 1

12_15% of cardiac output

Question 2

Cerebral blood flow (CBF)

Answer 2

50 ml/100 g/min
80% gray matter / 20% white matter

Question 3

How much of the brain energy consaption supports electrophysiologic function ?

Answer 3

60%

Question 4

Neurovascular coupling of brain

Answer 4

Increase cerebral activity (metabolism) ⇒ Increase CBF

Question 5

CBF autoregulated over MAP range

Answer 5

65-150 mmHg

Question 6

Chemical regulation of CBF

Answer 6

1) PaCO2 25-70 mmHg - CPF in normal range
2) If PaO2 less then 60 mmHg ⇒CBF increase dramatically
3) Reduction of body temperature ⇒suppression of cerebral metabolism

Question 7

Systemic vasodilatators and, CBF

Answer 7

Nstronglyarein, nitroprusside, hydroxyzine and Ca channel blockers ⇒vasodilate the cerebral circulation (depending on the MAP )

Question 8

Wave frequency of AWAKE

Answer 8

1) beta-activity
2)16-30Hz

Question 9

Stage-1 NREM sleep /

Answer 9

1) Alfa
2) 7,5-11Hz

Question 10

stage-2 NREM sleep

Answer 10

) theta wave
2) 4.5.7.5 Hz
3) sleep spindle and K-complex

Question 11

stage3 NREM sleep

Answer 11

^) 4 Hz
2) Delta

Question 12

REM - sleep

Answer 12

1) Theta wave

Question 13

Global CBF

Answer 13

45-55 ml/100g/min

Question 14

Cortical CBF

Answer 14

75-80 ml/100g/min

Question 15

Subcortical CBF

Answer 15

8-20 ml/100g/min

Question 16

Cerebral metabolic rate of oxygen (CMRO2)

Answer 16

3-3.5 ml/100g/min

Question 17

Cerebral vascular resistance (CVR)

Answer 17

1.5-2.1 mmHg/100g/min/ml

Question 18

ICP

Answer 18

8-12 mmHg

Question 19

Cerebral venous PO2

Answer 19

32-44 mmHg

Question 20

Cerebral venous SO2

Answer 20

55-70%

Question 21

Jugular venous oxygen saturation

Answer 21

60-70%

Question 22

Total CSF space

Answer 22

150 ml

Question 23

Total daily CSF production

Answer 23

450 ml

Question 24

Contraindications to thrombolysis

Answer 24

1)inability to identify onset of symptoms,
2) intracranial hemorrhage,
3) previous stroke or head trauma within 3 months,
4)recent intracranial or spinal surgery,
5) gastrointestinal malignancy or bleeding,
6) coagulopathy.

Question 25

Cerebral blood Volume

Answer 25

5 ml/100 g

Question 26

systolic BP for traumatic brain injury

Answer 26

1. 15-49 > 110 2. 50-69>100 3. >70 > 110

Question 27

Systolic blood pressure for aneurysmal subarachnoid hemorrhage

Answer 27

1) unsecured < 160 2) vesospasm bp>

Question 28

Blood pressure after cardiac arrest

Answer 28

1) SBP >90 mmHg 2) MAP> 65 mmHg

Question 29

Blood pressure for acute ischemic stroke without revascularization

Answer 29

Up to 220/120 mmHg

Question 30

Blood pressure for acute ischemic stroke with attempted revascularization

Answer 30

1) PretPA / mechanical thrombectomy <185/110 2) 24hours after tPA, during mechanical thrombectomy, incomplete thrombectomy<180/105 3) Post successful mechanical thrombectomy (2 /3 vascular territory) <140

Question 31

Systolic BP for Intracranial hemorrage

Answer 31

130-150 MmHg

Question 32

Central circulation is impair after acute stroke

Answer 32

2 weeks

Question 33

Restoration of autoregulation after acute stroke

Answer 33

1-3 month

Question 34

Effects of anesthetic agent on the rate of CST secretion

Answer 34

1) reduces Halotane, etomidate 2) increase Enflurane, desflurane

Question 35

Effects of anesthetic agent on the rate of CSF absorbtion

Answer 35

1) increase Isoflurane, fentanyl, etomidate 2) decrease halothane , enflurane

Question 36

Which gas potentially epileptogenic

Answer 36

Enflurane

Question 37

wich anesthetic potentially epileptogenic ? .

Answer 37

Etomidate

Question 38

Effects hypothermia for CMR

Answer 38

Decrease by 6-7% per degree Celsius

Question 40

CBF with PaCO2

Answer 40

1-2ml/100g/min