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YR5 Oncology > Cervical, Endometrial and Ovarian Cancer > Flashcards

Cervical, Endometrial and Ovarian Cancer Flashcards

1
Q

Most common histopathological type of cervical cancer

A

Squamous cell carcinoma

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2
Q

RF for cervical cancer

A

HPV, esp. 16 + 18

Late teens, early 20s

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3
Q

6 Sx of advanced cervical cancer

A 
PV bleeding
Postcoital bleeding 
Discharge
Pelvic/ back pain
Dyspareunia
Obstructive uropathy
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4
Q

What has caused reduction in incidence of cervical cancer?

A

HPV vaccination

PAP smears- often asymptomatic

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5
Q

2 potential findings on examination in cervical cancer

A

Cervical mass or bleeding

Abnormal colposcopy: abnormal vascularity

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6
Q

Ix for cervical cancer

A

PAP Smear
HPV testing
Colposcopy
Biopsy

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7
Q

Tx for cervical cancer

A

Hysterectomy + lymphadenectomy

Chemoradiation: Cisplatin + Radiotherapy

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8
Q

Tx for metastatic cervical cancer

A

Combination chemotherapy- Cisplatin + Paclitaxel

+/- Bevacizumab

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9
Q

Fertility preserving surgery for cervical cancer

A

Cone biopsy or simple extra-fascial hysterectomy

Radical trachelectomy + lymphadenectomy

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10
Q

Most common histopathological type of endometrial cancer

A

Adenocarcinoma

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11
Q

RF for endometrial cancer

A 
Overweight/ obese
HRT
PCOS
FH
Lynch synd
PTEN tumor suppressor mutation (Cowdens)
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12
Q

Sx of endometrial cancer

A

post-menopausal vaginal bleeding (PVB)

Pelvic pain + palpable mass (Late stage)

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13
Q

Ix for endometrial cancer

A

Transvaginal US

Endometrial biopsy + histopathology

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14
Q

Tx for endometrial cancer

A 
Total hysterectomy
Bilateral salpingo-oophorectomy
Lymphadenectomy
Adjuvant vaginal brachytherapy 
Adjuvant Paclitaxel + Carboplatin 
Adjuvant external beam radiation
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15
Q

Tx for early stage endometrial cancer fertility preserving

A

Progestin: megestrol

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16
Q

Most common histopathological type of ovarian cancer

A

Epithelial

malignant transformation of epithelium covering ovarian capsule + distal fallopian tube

17
Q

5 RFs for ovarian cancer

A 
BRCA 1 + BRCA2
Lynch synd
High no. lifetime ovulations
Age
FH
18
Q

Common presentation of ovarian cancer

A

Asymptomatic

Mild/ non-specific Sx

19
Q

5 Signs/ Sx in ovarian cancer

A 
Adnexal mass
Ascites
Urinary urgency/ frequency
Abdominal distension/ bloating + Early satiety
PVB/ PR bleeding
20
Q

Ix for ovarian cancer

A

Transvaginal pelvic US
Serum CA-125
Surgical evaluation

21
Q

Why are biopsy + fine-needle aspiration (FNA) not recommended for definitive dx?

A

Can disseminate tumour cells into peritoneal cavity

22
Q

Tx for ovarian cancer

A

Surgical staging + de-bulking
Adjuvant Paclitaxel + Carboplatin
+/- Bevacizumab (maintenance)

23
Q

In BRCA positive ovarian cancer, what targeted therapy may be used for maintenance?

A

Olaparib

PARP inhibitor

YR5 Oncology (8 decks)

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