Ch 10: Blood Vessels Flashcards Preview

Pathology Unit 2 > Ch 10: Blood Vessels > Flashcards

Flashcards in Ch 10: Blood Vessels Deck (18):
1

Immune mechanisms involved in vasculitis

1) deposition of immune complexes 2) direct attack on vessels by circulating Ab 3) Various forms of cell-mediated immunity

2

p-ANCAs are mainly against what ag?

MPO (myeloperoxidase)

3

c-ANCAs are mainly against what ag?

PR3 (proteinase 3)

4

Acute phase: Endothelial injury and denudation, ballooning degeneration of intimal smooth muscle cells & macrophages & medial smooth muscle cell necrosis, which may be fibrinoid.
Chronic phase: intimal hyperplasia and fibrosis of the vessel wall. Occasionally, vessels show complete fibrous occlusion.

Radiation Vasculitis

5

What are the Large vessel vasculitis diseases?

Giant Cell (temporal) Arteritis
Takayasu Arteritis

6

What are the medium vessel vasculitis diseases?

Polyarteritis Nodosa
Kawasaki Disease

7

What are the small vessel vasculitis diseases?

Microscopic Polyangitis
Granulomatosis w/ Polyangitis (Wegener's)
Eosinophilic Granulomatosis w/ Polyangitis (Churg Strauss)
IgA Vasculitis (Henoch-Schonlein)

8

ANCA associated with Granulomatosis w/ Polyangitis (Wegener's)

c-ANCA

9

ANCA associated with Microscopic Polyangitis

p-ANCA

10

ANCA associated with Eosinophilic Granulomatosis w/ Polyangitis (Churg-Strauss)

p-ANCA

11

Classic findings seen in Granulomatosis w/ Polyangitis

Sinusitis, hemoptysis w/ bilateral lung infiltrates, hematuria due to progressive glomerulonephritis

12

Classic findings seen in IgA Vasculitis (Henoch-Schonlen Purpura)

Palpable purpura on the buttocks and legs, GI Pain, hematuria (IgA Nephroathy)

13

Classic findings seen in Thromboangitis Obliterans (Buerger Disease)

Ulceration, gangrene and autoamputation of fingers and toes, Raynaud phenomenon is often present

14

Classic findings seen in Kawasaki Disease

Non-specific signs: fever, conjunctivitis, erythematous rash of palms and soles and enlarged cervical lymph nodes

15

Classic findings seen in Polyarteritis Nodosa

Seen in young adults w/ hypertension, abdominal pain w/ melena, neurologic disturbances and skin lesions

16

Classic findings seen in Eosinophilic Granulomatosis w/ Polyangitis (Churg- Strauss)

Asthama & peripheral eosinophilia

17

Classic Findings seen in Microscopic Polyangitis

NO nasopharyngeal involvement of granulomas (differentiates from Wegeners)

Hemoptysis w/ bi-lateral lung infiltrates, hematuria due to progressive glomerulonephritis

18

Classic Findings seen in Takayasu Arteritis

Present in adults ) in the upper extremity, ESR is elevated