Flashcards in Ch 10: Blood Vessels Deck (18):
Immune mechanisms involved in vasculitis
1) deposition of immune complexes 2) direct attack on vessels by circulating Ab 3) Various forms of cell-mediated immunity
p-ANCAs are mainly against what ag?
c-ANCAs are mainly against what ag?
PR3 (proteinase 3)
Acute phase: Endothelial injury and denudation, ballooning degeneration of intimal smooth muscle cells & macrophages & medial smooth muscle cell necrosis, which may be fibrinoid.
Chronic phase: intimal hyperplasia and fibrosis of the vessel wall. Occasionally, vessels show complete fibrous occlusion.
What are the Large vessel vasculitis diseases?
Giant Cell (temporal) Arteritis
What are the medium vessel vasculitis diseases?
What are the small vessel vasculitis diseases?
Granulomatosis w/ Polyangitis (Wegener's)
Eosinophilic Granulomatosis w/ Polyangitis (Churg Strauss)
IgA Vasculitis (Henoch-Schonlein)
ANCA associated with Granulomatosis w/ Polyangitis (Wegener's)
ANCA associated with Microscopic Polyangitis
ANCA associated with Eosinophilic Granulomatosis w/ Polyangitis (Churg-Strauss)
Classic findings seen in Granulomatosis w/ Polyangitis
Sinusitis, hemoptysis w/ bilateral lung infiltrates, hematuria due to progressive glomerulonephritis
Classic findings seen in IgA Vasculitis (Henoch-Schonlen Purpura)
Palpable purpura on the buttocks and legs, GI Pain, hematuria (IgA Nephroathy)
Classic findings seen in Thromboangitis Obliterans (Buerger Disease)
Ulceration, gangrene and autoamputation of fingers and toes, Raynaud phenomenon is often present
Classic findings seen in Kawasaki Disease
Non-specific signs: fever, conjunctivitis, erythematous rash of palms and soles and enlarged cervical lymph nodes
Classic findings seen in Polyarteritis Nodosa
Seen in young adults w/ hypertension, abdominal pain w/ melena, neurologic disturbances and skin lesions
Classic findings seen in Eosinophilic Granulomatosis w/ Polyangitis (Churg- Strauss)
Asthama & peripheral eosinophilia
Classic Findings seen in Microscopic Polyangitis
NO nasopharyngeal involvement of granulomas (differentiates from Wegeners)
Hemoptysis w/ bi-lateral lung infiltrates, hematuria due to progressive glomerulonephritis