Ch 15 Flashcards
Which is the most common portal of entry for mucous membranes ?
Respiratory tract
T or F. ID50 & LD50 determine strength of microorganism
T
____ stands for infectious dose for 50% of test population
ID50
______ stands for lethal dose of a toxin for 50% of test population
LD
If LD50 for botulinum toxin is 0.03kg and shiga toxin is 250kg which is stronger?
Botulinum because less amount is required to do more harm
T or F. If pathogen has a capsule it is more virulent
T
____ prevent phagocytosis
Capsules
___ protein resist phagocytosis
M
____ and fimbriae helps attach to host cell, then host cdll takes in bacteria. This also inhibits T helper cells
Opa
____ ____ (waxy lipid) that resist digestion by phagocytes so they reproduce inside the phagocytes.
Mycolic acid
Bacteria use ____ to survive phagocytosis
Enzymes
These are examples of \_\_\_\_\_ to \_\_\_ \_\_\_\_ Use host’s nutrients Direct Damage Production of toxins Hypersensitive Reactions Disrupt host cell function Produce waste products Toxins
Damage to host cells
Exotoxins classification (by location) \_\_\_\_-toxin effects nervous system. And is the most leather
Neuro
Exotoxins classification (by location) \_\_\_\_-toxin effects digestive system. (Lining of intestinal tract)
Enterotoxin
Exotoxins classification (by location) \_\_\_\_-toxin effects cells. Inhibits protein synthesis
Cytotoxin
Exotoxins classification (by structure and function) \_\_\_\_-toxin consist of 2 parts (polypeptides). \_\_\_\_ is the active part (enzyme). \_\_\_\_ is the binding component.
A-B toxins
Exotoxins classification (by structure and function) \_\_\_\_ \_\_\_\_\_ toxins cause lysis of host cells by disrupting plasma membrane by forming protein channels or disrupting the phospholipid portion of membrane.
Membrane disrupting toxin
Exotoxins classification (by structure and function) \_\_\_\_ \_\_\_\_\_ are bacterial proteins. It’s an antigen that provokes an intense immune response. Stimulates T cells to release high amount of cytokines that enter blood stream and cause intense symptoms
Super antigens
Endocrine toxins are found in gram ___
Negative
Endotoxins are in gram negative’s ____ cell wall
Outer
Can endotoxins be neutralized with antitoxins?
No has to be a protein to be neutralized with antitoxin and endotoxins are lipopolysaccharides
In LAL assay does the endotoxins cause lysis?
T
Amebocyte lysis causes clot in _ _ _ assay
LAL assay
T or F. Fungal waste products do not cause symptoms
F they do