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GI II > Ch 18 - Liver & Gallbladder > Flashcards

Ch 18 - Liver & Gallbladder Flashcards

(76 cards)

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1
Q

small and shrunken liver

A

liver failure

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2
Q

diffuse of liver cells w/out obvious death and parenchymal collapse

A

diffuse microvesicular statosis

  • fatty liver of preg
  • idiocsyncratic rxns to toxins
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3
Q

50% of acute liver failure in the US is d/t?

A

acetaminophen

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4
Q
  • N/V
  • jaundice/icterus
  • itching
  • coagulation abnormalities
  • elevated LFTs
  • possible portal HTN
  • aserixis
A

acute liver failure

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5
Q
  • ascites
  • formation of portosystemic venous shunts
  • congestive splenomegaly
  • hepatic encephalopathy
A

portal HTN

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6
Q

hepatitis ass’d with carrier state

A

HBV ( somtimes HCV)

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7
Q

early HBV infection confers high risk of what later in life?

A

HCC

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8
Q

progressive chronic HBV leads to?

A

cirrhosis

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9
Q

hepatitis ass’d w/ needle sticks and IVDA

A

HCV

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10
Q

chronic disease occurs in the majority of what kind of hepatitis inf?

A

HCV

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11
Q

dx of HCV is done with what serum marker?

A

elevated serum transaminases

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12
Q

hepatits that can have normal serum transaminase levels?

A

HBV

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13
Q

2 settings ass’d with HDV

A
  • superinfection: get HDV when you already have HBV

- coinfection: getting inf with HBV and HDV at the same time

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14
Q

ground glass cells in the liver

A

HBV

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15
Q

fatty changes to liver cells (type of hep)

A

HCV

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16
Q

dense mononuclear infiltrates in the liver

A

chronic hepatits

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17
Q

expanded lymphoid follicle in the liver

A

HCV

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18
Q

interface hepatitis

A

chronic hepatits

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19
Q
  • severe necroinflammatory activity
  • plasma cell predominance in mononuclear infiltrates
  • hepatocyte “rosettes”
A

autoimmune hepatitis

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20
Q

autoimmune hep ass’d with ANA and ASMA in older F

A

type 1

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21
Q

autoimmune hep ass’d with anti-LKM1 in children and teens

A

type 2

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22
Q
  • fatty chage/steatatosis
  • steatohepatitis
  • steatofibrosis > cirrhosis
A

patterns of injury ass’d with etoh liver dz

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23
Q
  • hepatocyte swelling and necrosis
  • Mallory-Denk bodies
  • neutrophilitis
A

steatohepatitis

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24
Q

hepatomegaly with minimal symptoms, elevated billi and alk phos

A

steatosis

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25
- tender hepatomegaly - +/- cholestasis - hyperbilirubinemia - ALT:AST = 2:1 - elevated alk phos - nonspecific s/s
steatohepatitis
26
clumped, amorphic, eosinophilic material in ballooned hepatocytes made up of tangled keratins and other proteins like ubiquitin
mallory-denk bodies
27
chicken wire fence pattern
etoh steatofibrosis
28
MCC of chronic liver disease in the US
NAFLD/NASH
29
massion trichrome stain
collagen in cirrhosis or steatofibrosis (seen in NAFLD too)
30
- hepatomegaly - abn skin pigmentation - DM - cardiac dysfxn - hypogonadism
hemochromatosis
31
- def in ATP7B | - failure to encorporate Cu in ceruloplasmin
wilson dz
32
inheritance of wilson dz
AR
33
MCly dx'ed inherited hepatic disorder of infants and children
A1-AT deficiency
34
inheritance pattern of A1-AT def
AR
35
glu342 > lys342
A1-AT deficiency
36
magenta cytoplasmic granules on PAS
A1-AT deficiency
37
HFE mutation
hereditary hemachromatosis
38
- absent UGT1A1 activity | - fatal in neonatal period
Cigler-Najjar I
39
inheratence of Crigler-Najjar I
AR
40
jet black liver
rotor syndrome
41
pigmented cytoplasmic globules in the liver
Dubin-Johnson syndrom
42
- jaundice - puritis - xanthomas - malabsorption - elevated alk phos & GGT
cholestasis
43
cause of cholestasis in adults
large duct obst
44
cause of cholestasis in children
CF and other syndromes
45
cause of cholestasis in neonates
biliary atresia
46
- jaundice - RUQ pain - fever
charcot's triad: acute cholagitis
47
complete or partial obst of lumen of extrahepatic biliary tree w/in first 3 mo of life
biliary atresia
48
biliary atreasia ass'd with other anomalies
fetal form
49
biliary atresia thougth to be ass'd with viral inf and/or autoimmune dz
perinatal form
50
florid features of extrahepatic biliary obst
biliary atresia
51
- MC in F - high ass't with Sjogren synd - AMA + - florid duct lesions - loss of small ducts
PBC
52
- MC in M - high ass't with IBD (MC in UC) - 65% are ANCA + - strictures and beading of large bile ducts - pruning of smaller bile ducts - onion skin lesions
PSC
53
- hepatic vv obst - abd pain - ascites - hepatomegaly
budd-chiari syndrome
54
MCC of jaundice in pregnancy
infection
55
3 hepatic diseases ass'd with preg
- pre-eclampsia and eclampsia - chlolestasis of pregnancy (++conj bili) - acute fatty liver
56
- HTN - edema - proteinuria - coag abn - pregnant! - +/- seizures
pre/eclampsia
57
- puritis - dark urine - light stools - pregnant!
cholestasis of preg
58
preg with + oil red O stain on liver biopsy
fatty liver of preg
59
- singe wide demarcated lesion - young - middle aged - liver is normal - central scar - loss of normal architecture
focal nodular hyperplasia
60
- looks like cirrhosis w/ no fibrous septa - can devo portal HTN - ass'd with HIV, rheumatologix dz, SLE
nodular regerative hyperplasia
61
- MC benign neoplasm of the liver | - MC in F
cavernous hemagioma
62
adenomas are ass'd with what drug in women?
OCs
63
type of adenoma that confers v high risk of malignant transformation
beta-catenin activated adenoma
64
- MC liver tumor of early childhood | - ass'd with wnt signaling ptwy
hepatoblastoma
65
- MC primary malignancy of hepatocytes | - inc AFP
HCC
66
MC sites of HCC mets
lung, R heart
67
-young adult (
fibrolamellar carcinoma
68
perihilar cholangiocarcinoma
klaskin tumor
69
MC sites liver gets mets from
- colon - breast - lung - pancreas
70
MODY-3
NHF1-alpha inactivated adeomas
71
liver fluke
cholangiocarcinoma
72
black stone
hemolytic anemia
73
brown stones
infected bile
74
ABCG8 gene
cholesterol stones
75
ERBB2
gallbladder carcinoma
76
MC typer of gallbladder ca
adenocarcinoma

GI II (12 decks)

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