Ch. 20: Carboxylic Acids and Their Derivatives Flashcards
1
Q
Preparation of Carboxylic Acids (Reagents)
A
- NaCN 2. H3O+, heat
or 1. Mg 2. CO2 3. H3O+
2
Q
Reactions (reduction) of Carboxylic Acids (Reagents)
A
- XS LAH 2. H3O+
or BH3 THF
3
Q
Preparation of Acid Chlorides (reagents)
A
SOCl2
4
Q
Acid Chloride/Anhydride to Carboxylic Acid
A
H2O
5
Q
Acid Chloride /Anhydride to Ester
A
ROH, py.
6
Q
Acid Chloride /Anhydride to Amide (NH2)
A
XS NH3
7
Q
Acid Chloride /Anhydride to 2 Amide
A
XS RNH3
8
Q
Acid Chloride /Anhydride to 3 Amide
A
XS R2NH
9
Q
Acid Chloride /Anhydride to Alcohol
A
- XS LAH 2. H3O+
10
Q
Acid Chloride /Anhydride to Aldehyde
A
- LiAl (OR)2H 2. H3O+
11
Q
Acid Chloride /Anhydride to Alcohol (w/ R)
A
- XS RMgBr 2. H3O+ (Grignard)
12
Q
Acid Chloride /Anhydride to Ketone (w/ R)
A
R2CuLi (Gilman)
13
Q
Carboxylic Acid /Anhydride to Ester (2)
A
- NaOH 2. Ch3I
or [H+], MeOH
14
Q
Ester to carboxylic acid (2)
A
H3O+
or 1. NaOH, heat 2. H3O+
15
Q
Ester to 3 Alcohol
A
- XS R’MgBr 2. H3O+
