Ch 22

Question 1

What type of neuronal injury involves swelling of soma and axons “spheroids” (reversible or irreversible)

Answer 1

Reversible

Question 2

What type of neuronal injury involves displacement of Nissl body and atonal sprouting (reversible or irreversible)

Answer 2

Reversible

Question 3

What type of neuronal injury involves a soma shrinking, pyknosis, eosinophilia (reversible or irreversible)

Answer 3

Irreversible

Question 4

What type of neuronal injury involves “red neurons”, cerebral edema, loss of nucleus & Nissl body (reversible or irreversible)

Answer 4

Irreversible

Question 5

Astrocyte injury leads to ___________ & ___________

Answer 5

Hypertrophy & hyperplasia

Question 6

Oligodendrocytes are activated after damage to _________ ___________

Answer 6

White matter

Question 7

Are oligodendrocytes or astrocytes a site for viral inclusions

Answer 7

Oligodendrocytes

Question 8

What are the phagocytes of the CNS

Answer 8

Microglia

Question 9

Microglia ________ & __________ after injury

Answer 9

Proliferate and enlarge

Question 10

___________ cells line ventricles & spinal cord

Answer 10

Ependymal cells

Question 11

What type of virus invades ependymal cells

Answer 11

Cytomegalovirus

Question 12

Choroid plexus dysfunction affecting CSF production can be a pathology of what type of cell

Answer 12

Ependymal cell

Question 13

What type of virus presents with a Negri body

Answer 13

Rabies

Question 14

What type of virus presents with “owl’s eye appearance”

Answer 14

CMV (cytomegalovirus)

Question 15

Astrocytes perform __________ (CNS fibrosis)

Answer 15

Gliosis

Question 16

What neurodegenerative disease produces “Lewy bodies”

Answer 16

Parkinson’s disease

Question 17

What neurodegenerative disease produces Neurofibrillary tangles and B-amyloid plaques

Answer 17

Alzheimer’s disease

Question 18

What is lipofuscin

Answer 18

Aging, lipid accumulation

Question 19

Does vasogenic or cytotoxic edema disrupt the blood brain barrier

Answer 19

Vasogenic edema

Question 20

Does vasogenic or cytotoxic edema disrupt neuronal/glial membranes

Answer 20

Cytotoxic edema

Question 21

Is vasogenic or cytotoxic edema intracellular

Answer 21

Cytotoxic edema is intracellular

Question 22

Does vasogenic or cytotoxic edema lead to extracellular edema

Answer 22

Vasogenic edema leads to extracellular edema

Question 23

What is the term for increased volume of CSF within ventricles

Answer 23

Hydrocephalus

Question 24

What is the most common cause of hydrocephalus

Answer 24

Choroid plexus tumor

Question 25

Is communicating or non communicating hydrocephalus bilateral and even

Answer 25

Communicating hydrocephalus

Question 26

Is communicating or non communicating hydrocephalus localized and uneven

Answer 26

Noncommunicating hydrocephalus

Question 27

What percentage of hydrocephalus is idiopathic

Answer 27

50%

Question 28

Hydrocephalus __ _______ results in infarction or neiurodegeneration

Answer 28

Hydrocephalus ex vacuo

Question 29

What is the term for increased volume of CSF within ventricles

Answer 29

Hydrocephalus

Question 30

What is the most common treatment for hydrocephalus

Answer 30

Shunting