Ch. 24: Microbial Diseases of Respiratory System Flashcards

(38 cards)

1
Q

What is the primary cause of respiratory infections or follow a viral infection

A

Bacteria

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2
Q

What is streptococcus pyogens

A

streptococcal pharyngitis (strep throat); scarlet fever
(β-hemolytic strep —> S. pyogenes)

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3
Q

What are the upper respiratory tract infections?

A

-streptococcal; pharyngitis
-scarlet fever
-Diphtheria

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4
Q

What is scarlet fever

A

-erythrogenic toxin produced by lysogenized S. Pyogenes
-causes pinkish-red skin rash & fever

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5
Q

Is diphtheria uniform in shape?

A

No

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6
Q

What is corynebacterium diphtheria

A

Gram-positive, club-shaped rods/ pleomorphic; diphtheria; toxin producer; DTaP vaccine

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7
Q

What is streptococcal pharyngitis resistant to

A

-streptokinases lyse clots
-streptolysins are cytotoxic

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8
Q

How does the Diphtheria disease spread

A

begins with a sore throat & fever; spread by droplet transmission

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9
Q

In diphtheria what membrane forms

A

pseudomembrane

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10
Q

What is the pseudomembrane

A

tough, grayish membrane in the throat that can restrict airflow

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11
Q

What is a toxin producer

A

toxin circulates in the bloodstream, and interferes with protein synthesis

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12
Q

What immunization has limited Diphtheria cases to <5/year

A

DTaP vaccine

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13
Q

Diphtheria is what type of disease

A

cutaneous (infects the skin)

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14
Q

What are the lower respiratory tract diseases

A

streptococcus pneumonia, Legionella pneumophila, Bordetella pertusis

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15
Q

What is pneumonia

A

a disease, not a specific infection, caused by many types of microbes

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16
Q

What is streptococcus pneumonia (α-hemolytic)

A

typically a secondary infection

17
Q

How is streptococcus pneumonia spread

A

airborne droplets

18
Q

Streptococcus pneumonia has a capsule that prevents what

19
Q

Where does streptococcus pneumonia proliferate

A

alveolar spaces (like the bronchi; fluid build-up occurs)

20
Q

Streptococcus pneumonia can spread to what

A

bloodstream & brain (meningitis)

21
Q

What is the vaccine for streptococcus pneumonia

A

Pneumococcal polysaccharide vaccine (PPV)

22
Q

What is legionella pneumophila

A

gram-negative, non-encapsulated, aerobic bacillus with a single, polar flagellum

23
Q

Where is legionella pneumophila found

A

In fresh water

24
Q

What type of parasite is legionella pneumophila

A

intracellular parasite invades and replicates amoeba in the environment (ubiquitous in nature)

25
In humans, L pneumophila invades and replicates inside what
macrophages via invasins
26
what is the the human infection of Legionella pneumophila
Inhalation of aerosols provided by cooling towers, air conditioners, hot tubs
27
What are the signs and symptoms of legionnaires disease
cough, shortness of breath, high fever, muscle pains, headaches; may have nausea & vomiting
28
What is the diagnosis of legionnaires disease
urinary antigen test & sputum culture
29
What is the prevention of legionella pneumophila
good maintenance of water systems
30
What is then treatment of legionnaires disease
with antibiotics
31
What is Bordetella pertussis
aerobic, Gram-negative coccobacillus
32
What does the Bordetella pertussis inhibit
the mucociliary escalator by binding to lung ciliated cells in the trachea, then progressively destroying them
33
What is the virulence factors of Bordetella pertusis
capsule; toxins
34
what is pertussis toxin
enters blood, results in systemic symptoms of disease
35
What is the catarrhal stage in Bordetella pertussis
resembles common cold
36
What is the paroxysmal stage
violent coughing; gasping for air; 1-6 weeks
37
What is the convalescence stage
months
38
What is the vaccine for Bordetella pertussis
DTaP vaccine