CH 36: Antifungals Flashcards
(14 cards)
Who is at risk of acquiring fungal infection?
Patients with compromised immune systems
AIDS, HIV, immunosuppressed, thrush
anti TB drug mainly used
isoniazid
adverse effects of isoniazid
hepatotoxicity
neurotoxicity
monitor neuro signs, liver signs,
labs for isoniazid
liver fx
cbc
renal fx
sputum culture for AFB!!
fungal infections term
mycoses
systemic fungal infections happen in:
internal organs:
lungs
brain
digestive organs
superficial mycoses affects where:
scalp
skin
nails
mucous membranes, such as the oral cavity and vagina
steroid used for fungal cells
ergosterol
largest class of antifungals
azoles
MOA of azoles
inhibit ergosterol biosynthesis, causing the fungal plasma membrane to become porous or leaky.
primary anti fungal prototype drug
amphotericin B
nursing considerations for amphotericin B
Infuse slowly because cardiovascular collapse may result if the medication is infused too rapidly.
adverse effects of amphotericin B
Nephrotoxicity!
liver failure!
anaphylaxis
cardiac arrest
thrombocytopenia
leukopenia
agranulocytosis
anemia
labs for amphotericin B
renal fx
liver fx
K
Ca
Mg
CBC
