Ch 5: Cell Survival Curve

Question 1

Non-mitotic death is synonymous with?

Answer 1

Interphase death

Question 2

What happens in division delay?

Answer 2

Cells enter G0 and radiation is not effective

Question 3

What happens in interphase death?

Answer 3

Cells do no need to enter into mitosis and death occurs via apoptosis

Question 4

What happens in reproductive failure?

Answer 4

Death is not immediate but cells lose enough chromosome information that eventually cause cell death

Question 5

Characterized by single strand breaks that can be repaired

Answer 5

(SLD) sub lethal damage

Question 6

Dose is high enough to kill cells but cells may not be cycling and are therefore more likely to survive

Answer 6

(PLD) potentially lethal damage

Question 7

If a radio-sensitizer is added to sparsely ionizing radiation, what happens to the survival curve?

Answer 7

The survival curve moves to the left

Question 8

______ is defined as the dose required to reduce the fraction of cells surviving to 37 percent

Answer 8

Do

Question 9

The slope of a cell survival irradiated with alpha particles is ______ than a survival curve irradiated with sparsely ionizing radiation

Answer 9

Steeper

Question 10

The shoulder of the cell survival curve is formed by

Answer 10

(SLD) sub lethal damage

Question 11

Dq is dependent on

Answer 11

Type of radiation damage (direct or indirect)
Cell type
Environmental conditions

Question 12

With a plating efficiency of 90 percent, if 43 colonies of cells remaining after a dose of radiation is given to 1000 cells, what is the surviving fraction?

Answer 12

0.048

Question 13

Radiation of neutrons or alpha particles exhibit _______ shoulder on the cell survival curves.

Answer 13

No

Question 14

Programmed cell death is know as?

Answer 14

Apoptosis

Question 15

How can you overcome division delay

Answer 15

By increasing radiation dose

Question 16

Division delay is:

When cell haven’t been killed, instead they are like being stunned. Cell will enter G0 phase, which will provided them enough time to recover from any damage from radiation

Answer 16

True

Question 17

In interphase death, cell does not need to undergo mitosis and cell death is from apoptosis or necrosis

Answer 17

True

Question 18

Reproductive failure is:

Is NOT immediate death, but cells can be considered dead b/c cells consequently have loss aspects of their chroma tins and chromosome and thus with each division, less info will be transmitted to daughter cell

Answer 18

True

Question 19

Dq is?

Answer 19

The shoulder, indicates ability to repair

Question 20

D0?

Answer 20

Dose required to reduce the fraction of cells serving to 37 percent. It is the sensitivity.

Question 21

Dq is dependent on?

Answer 21

Type of radiation (indirect or direct)

Cell type and cell condition

Question 22

The larger the shoulder , the larger the Dq, the more radiation is required to get equivalent amount of cell death

Answer 22

True

Question 23

How is D10 calculated?

Answer 23

2.3 times D0. Answer will be in Gy.

Question 24

What are the 2 distant terms for DNA damage

Answer 24

SLD

PLD

Question 25

PLD is when enough radiation is given to cause death but since the cell is NOT cycling, the damage cannot manifest fully

Answer 25

True

Question 26

SLD is measured by?

Answer 26

Dq; the shoulder; the Bailey to repair

Question 27

Example of a suboptimal condition in PLD

Answer 27

Hypoxia

Inadequate nutrient

Question 28

Densely ionizing (alpha and neutrons) is NOT impacted by O2, radiosensitizer or radioprotectors

Answer 28

True

Question 29

If you add radiosensitizer to sparsely ionizing, it will move to the ______.

Answer 29

Left

Question 30

If you add radioprotectors to the sparsely ionizing, it will move to the ______

Answer 30

Right

Question 31

Densely ionizing particles work through DIRECT damage, no slope means at any given dose wil cause DNA damage

Answer 31

True

Question 32

Sparsely ionizing works though INDIRECT.

Answer 32

True

Question 33

Low dose to densely will give same effect as sparsely

HIGH dose to sparsely will give same effect as densely

Answer 33

True

Question 34

As D0 increases, cell becomes ore resistant

Answer 34

True

Question 35

As DO decrease, cell become more sensitive

Answer 35

True