Ch. 7 Tumor Suppressor Genes Flashcards
Cancer cells derived from most kinds of
non-virus-induced human tumors
hybrid cells non-tumorigenic
Cancer cells derived from viral-induced
tumors
tumorigenic
Non-familial form of retinoblastoma
Sporadic -Unilateral
Familial form of retinoblastoma
Bilateral Retinoblastoma
Hemizygosity
LOH can occur by simply breaking off and discarding an entire chromosomal region without replacing it with a copy from the other homologous chromosome
Identification of tumor suppressor genes by
identifying frequently deleted segments of
chromosomes
Localized regions of DNA with a high density of CpGs called “CpG islands” are
inappropriately methylated in cancer cells
Development of benign tumors on the cell sheaths
around nerves in the peripheral nervous system
Neurofibromatosis
The NF1 Protein acts as a
negative regulator of Ras signaling
Loss of NF1 can
mimic the hyperactivated Ras proteins that are created by mutant Ras oncogenes
Mutations that replace this arginine residue
result in
a 1000 fold decrease in GTPase stimulating activity
Epithelial cells in the gastrointestinal tract
enterocytes
APC
product of the adenomatous polyposis gene – negatively controls the levels of β-catenin in the cytosol
Von Hippel-Lindau syndrome
hereditary predisposition to the development of a variety of tumors, including carcinomas of the kidney, tumors of the adrenal gland, and blood vessel tumors of the central nervous system and retina
pVHL recognizes the hydroxyprolines on HIF-1ɑ
and together with other proteins adds ubiquitin to HIF to trigger its degradation
normoxia
