Ch 9 Repair Enzymes

Question 0

MutL

Answer 0

Activates MutH in E Coli

Question 1

MutS

Answer 1

E Coli-scans DNA

Question 2

MutH

Answer 2

Cleaves DNA in E Coli

Question 3

MSH

Answer 3

Human-MutS

Interacts - sliding clamp

Question 4

MLH/PMS

Answer 4

Homologue of MutL

Question 5

Photolyase

Answer 5

Photoreactivation for Direct Reversal

E Coli

Question 6

Methyltransferase

Answer 6

Group removal in Direct Reversal

Question 7

Glycolase

Answer 7

MutM in E Coli
Removes G in oxoG:A
Base Excision Repair

Question 8

MutT

Answer 8

Error Avoidance-E Coli

Remove G in oxoG b4 incorporation

Question 9

MutY

Answer 9

E. Coli- Failsafe in Base Excision

Remove A in oxoG:A

Question 10

MTH1

Answer 10

=MutT

In human Chr7p22

Question 11

UvrA

Answer 11

Complex + Uvrb

Scan DNA in E. Coli Nucleotide Excision Repair

Question 12

Uvrb

Answer 12

Recruits Uvrc

NER E.Coli

Question 13

UvrC

Answer 13

Cut 8nt on 5’
4-5 on 3’
NER E.Coli

Question 14

UvrD

Answer 14

Helicase

NER and Mismatch Repair in E. Coli

Question 15

XPC

Answer 15

Human NER

homo 4 UvrA

Question 16

XPA-XPD

Answer 16

Human NER

homo 4 UvrB

Question 17

ERCC1-XPF

Answer 17

Cut 5’ end in human NER

homo 4 UvrC

Question 18

XPG

Answer 18

Cut 3’ end in human NER

Homo 4 UvrC

Question 19

TFIIH

Answer 19

Transcription Coupled Repair

NER

Question 20

LexA

Answer 20

Transcriptional Repressor

E. Coli Translesion Synthesis

Question 21

UmuC/UmuD

Answer 21

DNA Poly V

E. Coli Translesion Syn

Question 22

DinB

Answer 22

DNA Poly IV

E. Coli Translesion Syn

Question 23

Ku 70/Ku 80

Answer 23

NHEJ

VDJ Recombination

Question 24

DNA-PKcs

Answer 24

Eu- NHEJ & VDJ Recomb

Question 25

Artemis

Answer 25

Eu- NHEJ & VDJ Recomb

Question 26

BRCA1

Answer 26

Tumor Suppress Gene Eu- Homo Recombination Breast Cancer 1

Question 27

BRAC2

Answer 27

Tumor Suppressor Bind & regulate proteins made by Rad51 Eu- HRR

Question 28

Rad51

Answer 28

Homo 4 Pro RecA & yeast Rad51 | Eu-HRR

Question 29

Chk1

Answer 29

Prevent entry to mitosis | UV damage, replication error, p53 activation

Question 30

Chk2

Answer 30

Prevent Mitosis Entry Interact BRCA1 = BRCA1 restore survival after damage Repair of ionizing radiation

Question 31

RAG1 & RAG2

Answer 31

Eu- VDJ recomb

Question 32

p53

Answer 32

``` 47 kDa Transcription Factor-recognize DNA erro -DNA Damage, osmotic shock, nucleotide depletion, oncogene start Hold cell G1 or S, or apoptosis 50% cancer has mutated p53 ```

Question 33

Cdk2

Answer 33

Cell cycle regulator

Question 34

ATM

Answer 34

Target- p53, BRCA2, chk2, H2AX, RAD, Activates- NHEJ, HRR, p53/chk2 Ds DNA Breaks