ch1 HEMATOPOIESIS

Question 1

Homogenous, continuous, aqueous solution in the cytoplasmic matrix

Answer 1

Cytosol

Question 2

Macromolecular complexes composed of small and large subunit of rRNA and many accessory ribosomal proteins. Ribosomes are found free in the cytoplasm or on the surface of rough endoplasmic reticulum Ribosomes serves as the site of protein synthesis

Answer 2

Ribosomes

Question 3

• Synthesizes phospholipids and steroids
• Detoxifies drugs
• Stores calcium

Answer 3

Smooth endoplasmic reticulum

Question 4

Synthesizes most membrane-bound proteins

Answer 4

Rough endoplasmic reticulum

Question 5

Term used for the non-mitosis stages of the cell cycle, that is, G1, S, and G2.

Answer 5

Interphase

Question 6

Two identical daughter cells are produced, each of which receives one entire set of the DNA that was replicated during the S phase

Answer 6

Mitosis – M phase

Question 7

Duration of Mitosis

Answer 7

1 hour

Question 8

• Also known as: Gap 1 phase
• Cell grows rapidly and performs its cellular functions
• Period of cell growth and synthesis of components necessary for replication.

Answer 8

Interphase – G1 phase

Question 9

• Also known as: Synthesis phase
• DNA is replicated
• An exact copy of each chromosome is produced and they pair together as sister chromatids.
• The centrosome is also duplicated during the S stage.

Answer 9

Interphase – S phase

Question 10

• Also known as: Gap 2 phase
  Period when the cell produces materials essential for cell division
• Tetraploid DNA is checked for proper replication and damage

Answer 10

Interphase – G2 phase

Question 11

Duration of G1 Phase

Answer 11

11 hours

Question 12

Duration of S Phase

Answer 12

8 hours

Question 13

Duration of G2 Phase

Answer 13

4 hours

Question 14

G0 Phase is also known as

Answer 14

Resting Phase

Question 15

• Cells are not active in cell cycle
• Some cells may enter this phase after G1 phase
• Normally do not re-enter the cell cycle and remain alive performing their function until apoptosis occurs

Answer 15

G0 Phase

Question 16

• Occur at the end of G1 phase
• Before DNA replication in S phase
• At the end of G2 phase before M phase

Answer 16

Checkpoint

Question 17

Present in small numbers in the bone marrow (<1% cells in the bone marrow)

Answer 17

Stem Cells

Question 18

• These cells are present in the first few hours after an ovum is fertilized.
• Can develop into any human cell type, including development from embryo into fetus.
• The most versatile type of stem cell.
• Give rise to all cell lineage
• Gives rise to CFU-S and CFU-L
• Can develop into any human cell type, including development from embryo into fetus.

Answer 18

Totipotent hematopoietic stem cell (THSC)

Question 19

• These cells are capable of giving rise to multiple lineages of blood cells
• Example: CFU-S and CFU-L

Answer 19

Pluripotential or Multipotential stem cell

Question 20

The identification and origin of stem cells can be determined by immunophenotypic analysis using

Answer 20

Flow Cytometry

Question 21

Characteristic of stem cell

Answer 21

• Capable of self-renewal
• Give rise to differentiated progeny
• Able to reconstitute the hematopoietic system of a lethally irradiated host

Question 22

Fate of Hematopoietic Stem Cell (HSC)

Answer 22

• Self-renewal
• Differentiation
• Apoptosis

Question 23

• Glycoprotein
• Encoded on Chromosome 1q
• Stem cell marker

Answer 23

Stem Cells

Question 24

Is a continuous, regulated process of blood cell production that includes cell renewal, proliferation, differentiation, and maturation.

Answer 24

Hematopoiesis

Question 25

Is a collective term used to describe the process involved in the production of blood cells from human stem cells (HSCs) with subsequent cellular differentiation and development

Answer 25

Hematopoiesis

Question 26

These processes result in the formation, development, and specialization of all of the functional blood cells that are released from the bone marrow to the circulation.

Answer 26

Hematopoiesis

Question 27

In healthy adults, hematopoiesis is restricted primarily to the

Answer 27

Bone Marrow

Question 28

Hematopoiesis occurs in the following parts of the body:

Answer 28

Bone marrow, liver, spleen, lymph nodes, and thymus

Question 29

In fetus, hematopoiesis takes place at various intervals in the

Answer 29

Liver, spleen, thymus, bone marrow, and lymph nodes

Question 30

Major locations of Hematopoiesis

Answer 30

Yolk sac, aorta-gonad-mesonephros (AGM) region, fetal liver, bone marrow, and thymus.