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APhA Naplex > Ch34 Anti-infective Agents > Flashcards

Ch34 Anti-infective Agents Flashcards

1
Q

What is the general spectrum of aminoglycosides? (2)

A
  1. Gram (-)

2. Select aerobic gram (+)

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2
Q

What is the mechanism for aminoglycosides? (2)

A
  1. Inhibit protein synthesis through binding to the 30S ribosomal subunit ā€œ3 (common aminoglycosides) 30Sā€
  2. This irreversibly inhibits bacterial RNA
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3
Q

Are aminoglycosides bactericidal or bacteriostatic?

A

Bactericidal

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4
Q

Which aminoglycosides are minimally absorbed and are used to decrease bacterial content in the bowel? (2)

A
  1. Kanamycin

2. Neomycin

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5
Q

What are important ADRs of aminoglycosides? (3)

A
  1. Nephrotoxicity
  2. Ototoxicity
  3. Neuromuscular blockade
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6
Q

What are risk factors for neuromuscular blockade caused by aminoglycosidses? (3)

A
  1. Myasthenia gravis
  2. Hypocalcemia
  3. Elevated peak concentrations
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7
Q

What nerve is damaged in aminoglycoside induced ototoxicity?

A

Eighth cranial nerve

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8
Q

How are aminoglycosides dosed?

A
  1. Actual body weight

2. Unless patient is obese 20% over ideal use adjusted

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9
Q

What is the equation for ideal body weight (only needed for aminoglycosides to calculate adjusted if obese)?

A

Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.
1. My ideal 6ft = 77.6

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10
Q

What is the equation for adjusted body weight?

A

IBW + 0.4(total body weight - ideal)

Ideal is on the outsides

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11
Q

What are the target serum concentrations for amikacin?

A
  1. Peak = 20-30mcg/ml

2. Trough = <10 mcg/ml

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12
Q

What are the target serum concentrations for gentamicin and tobramycin?

A
  1. Peak = 4-10mcg/ml

2. Trough = <2mcg/ml

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13
Q

Which aminoglycoside can be inhaled via nebulization?

A

Tobramycin

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14
Q

What is the rationale for extended interval dosing with aminoglycosides? What trait is helpful in this dosing?

A
  1. Designed to drive the peak very high to max the concentration dependent killing and allow troughs to fall to reduce toxicity
  2. They have a significant postantibiotic effect
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15
Q

What is the mechanism of penicillins?

A

Bind to penicillin binding protein in cell wall

Cell wall synthesis is inhibited

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16
Q

Are penicillins bactericidal or bacteriostatic?

A

Bactericidal

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17
Q

What does the chemical structure of penicillins consist of?

A
  1. Beta-lactam

2. Thiazolidine Ring

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18
Q

How are penicillins eliminated? Name two exceptions.

A
  1. Renal

2. Nafcillin and oxacillin are hepatic

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19
Q

What are examples of ā€œnatural penicillins?ā€ (2)

A
  1. Penicillin G

2. Penicillin V

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20
Q

What are examples of ā€œpenicillinase-resistant penicillins?ā€ (4)

A
  1. Oxacillin
  2. Nafcillin
  3. Cloxacillin
  4. Dicloxacillin
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21
Q

What are examples of penicillin + beta lactamase inhibitors? (4)

A
  1. Amoxicillin Clavulanic acid (Augmentin)
  2. Ticarcillin Clavulanic acid (Timentin)
  3. Ampicillin Sulbactacm (Unasyn)
  4. Piperacillin Tazobactam (Zosyn)
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22
Q

What is the spectrum of natural penicillins? (5)

A
  1. Viridans Streptococci
  2. Streptococcus pyogenes
  3. 60% Streptococcus Pneumoniae
  4. Clostridium Pefringens (gas gangrene)
  5. Mouth anaerobes
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23
Q

What bacteria are natural penicillins ineffective against?

A

Staphylococcus aureus (penicillinase)

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24
Q

What do aminopenicillins have greater penetration for and higher affinity for?

A
  1. The outer membrane of gram (-) rods

2. Penicillin binding proteins

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25
Are cephalosporins bactericidal or bacteriostatic?
Bactericidal
26
What is the mechanism of cephalosporins?
1. Inhibit mucopeptide synthesis in the bacterial cell wall | 2. Formation of defective cell walls
27
What is a common dose for penicillin G benzathine (Bicillin LA)? For syphilis treatment?
1. 2 million units IM single dose | 2. 4 million units IM single dose
28
What are the first generation cephalosporins? (3)
1. Cephalexin (Keflex) po 2. Cefadroxil (Duricef) po 3. Cefazolin (Ancef) IV" ALEX tried to keep up with the FADs but they FAZzled out"
29
What is the general spectrum for first generation cephalosporins?
More gram (+) than gram negative coverage
30
What are the second generation cephalosporins? (5)
1. Cefaclor (Ceclor) po 2. Cefuroxime (Ceftin, Zinacef) IV IM po 3. Cefoxitin (Mefoxin) IV 4. Cefotetan (Cefotan) IV IM 5. Cefprozil (Cefzil) po "The FACt is the FURry FOX crossed the TETANs like a PRO"
31
What is the general spectrum for second generation cephalosporins?
Enhanced gram (-) over 1st gen
32
What are the third generation cephalosporins? (7)
1. Cefpodoxime (Vantin) po 2. Ceftazidime (Fortaz, Tazicef) IV IM 3. Cefixime (Suprax) po 4. Cefdinir (Omnicef) po 5. Ceftriaxone (Rocephin) IV IM 6. Cefibuten (Cedax) po 7. Cefotaxime (Claforan) IV "Listening to his iPOD, TAZ was so FIXed on DINIR he fell off his TRIke onto his BUT and had to pay TAXes
33
What is the general spectrum for third generation cephalosporins?
1. More gram (-) than positive coverage | 2. Cerebrospinal fluid penetration
34
What is the general spectrum for third generation cephalosporins?
1. More gram (-) than positive coverage | 2. Cerebrospinal fluid penetration
35
What is the fourth generation cephalosporin?
Cefepime (Maxipime) IV IM
36
What is the fifth generation cephalosporin?
Ceftaroline (Teflaro) IV
37
What cephalosporins have antipseudomonal activity?
1. Ceftazidime | 2. Cefepime
38
Which cephalosporin has no gram (+) activity?
Ceftazidime
39
What cephalosporins have anaerobic coverage? (4)
Cefotetan 2nd Cefoxitin 2nd Cefprozil 2nd Cefpodoxime 3rd
40
Which cephalosporin has bleeding (hypoprothrombinemia) which is attributable to the presence of a N-methylthiotetrazole side chain?
Cefotetan
41
What cephalosporin can cause a disulfiram-like reaction with ingestion of alcohol?
Cefotetan
42
Which cephalosporins should be adjusted in renal insufficiency?
All but ceftriaxone (renal and via bile cleared)
43
What mechanism can cause bacterial resistance to cephalosporins?
Beta-lactamases
44
Are carbapenems beta-lactams?
They are beta-lactam-like | Structurally similar to penicillins
45
What is the mechanism for carbapenems?
Bind to penicillin binding proteins and inhibit peptidoglycan synthesis
46
Carbapenems are the DOC for what?
ESBL producing Enterobacteriaceae species
47
What is ESBL?
Extended Spectrum Beta-Lactamases
48
What is the general spectrum for carbapenems? (5)
1. Gram (+) 2. Gram (-) 3. Anaerobes 4. Atypical (Mycobacterium and chlamydia) 5. Pseudomonas Acinetobacter (not ertapenem)
49
What are the most common ADRs reported with imipenem? (2)
1. GI NVD (C.diff) | 2. Seizures reported in 0.4%
50
Why is cilastatin needed with imipenem?
It increases the AUC and urinary concentrations of imipenem
51
What is a difference in ADRs of meropenem and doripenem compared to imipenem?
Meropenem and doripenem have decreased CNS toxicity
52
What is a common dose for ertapenem?
1000 mg q24h
53
What type of bacterial killing do aminoglycosides have?
Concentration dependent
54
What type of bacterial killing do penicillins and cephalosporins have?
Time above the MIC dependent
55
What type of bacterial killing do fluoroquinolones have?
Concentration dependent
56
What condition cannot be treated with daptomycin?
Pneumonia
57
What condition should not be treated with linezolid?
Endovascular infections
58
What is the spectrum of clindamycin?
Anaerobes Gram (+) MRSA
59
What conditions are tetracyclines the DOC for? (2)
1. Lyme disease | 2. Rocky Mountain spotted fever
60
What is the general spectrum for macrolides?
1. Gram (+) | 2. Atypical
61
What is a BBW for telithromycin?
Hepatotoxicity
62
Why is aztreonam less likely to have cross-reactivity with penicillin allergy?
It does not have a beta lactam ring
63
What is the spectrum for aztreonam?
Gram (-)
64
Name two bacteria that linezolid is active against?
Enterococcus faceium and faecalis
65
What are some serious ADRs to linezolid? (3)
1. Myelosuppression 2. Neurotoxicity (peripheral neuropathy, and optic neuritis) 3. Lactic Acidosis
66
When are myelosuppression ADRs to linezolid more common to occur?
When therapy exceeds 14 days
67
What is an important drug interaction with linezolid? (4 classes, 1 agent involved)
1. It is a weak MAO inhibitor | 2. Caution with Sympathomimetics (Pseudoephedrine, NE, DA), SSRIs, TCAs, Triptans, Meperidine)
68
Where does linezolid achieve higher concentrations (tissue vs plasma)?
In tissue rather than plasma
69
What is the mechanism of daptomycin?
1. Causes rapid depolarization to bacterial cell membranes "rap depo dapto anagramish" 2. Loss of membrane potential inhibits protein, DNA, and RNA synthesis
70
What are 2 serious ADRs with daptomycin?
1. Rhabdomyolysis (increased creatine phosphokinase) | 2. Nephrotoxicity
71
What is the dose for daptomycin in treating pneumonia?
It cannot be used. It is inactivated by the surfactant in the lung
72
What is the mechanism of vancomycin? (2)
1. Inhibition of peptidoglycan synthesis polymerization and cross-linking 2. May also inhibit RNA synthesis
73
What is "red-man syndrome"?
Caused my histamine release associated with rapid IV infusion of vancomycin
74
How can the risk of "red-man syndrome be minimized?
1. Slow IV infusion of vancomycin | 2. NTE 500mg/30 mins
75
What is the volume of distribution of vancomycin?
0.7 L/kg (total body weight)
76
Are fluoroquinolones bactericidal or bacteriostatic?
Bactericidal
77
What is the mechanism of fluoroquinolones?
Inhibition of bacterial DNA gyrase and topoisomerase
78
What is an important counseling point fluoroquinolones
1. Ca, Mg, iron decrease absorption | 2. Antacids, dairy, and multivitamins should not be taken for at least 2 hours after dose
79
What is a BBW for fluoroquinolones?
1. Increased risk of tendinitis and tendon rupture (increased risk >60 years, children) 2. Avoid in myasthenia gravis
80
Are macrolides bactericidal or bacteriostatic?
Bacteriostatic
81
What is the mechanism for macrolides?
Bind to 50S RNA subunit thereby inhibiting RNA synthesis
82
What is the PO to IV conversion of azithromycin?
Equal
83
Macrolides are the DOC in what diseases? (2)
1. Atypical pneumonia | 2. Chlamydia
84
What is the difference between tetracyclines and tigecycline?
Same MOA but tigecycline has a structural modification that increases affinity and binding to the bacterial ribosome and decreases efflux from the cell
85
What are counseling points for tetracycline?
1. Best to take without food. Food interferes with absorption. However, food can minimize GI ADRs 2. Photosensitivity 3. Antacids, Dairy, Iron, Multivitamin should be avoided for several hours before and after (decrease tetracycline concentration)
86
What is an important serious ADR for sulfamethoxazole?
Dermatologic reactions (Steven-Johnson syndrome, rash, urticaria)
87
What antibiotic can induce clostridium difficile enterocolitis at higher rates?
Clindamycin
88
What miscellaneous antibiotic causes a disulfiram-like reaction?
1. Metronidazole | 2. Alcohol should be avoided 3 days before and after
89
What should be considered as an alternative to ceftriaxone in treating meningitis in patients with a life threatening b-lactam allergy? Why
1. Chloramphenicol | 2. It penetrates CNS
90
What is the mechanism which explains why chloramphenicol has limited use?
It's toxicities are caused by inhibition of mammalian protein synthesis
91
What is the BBW for chloramphenicol? (3)
1. Can cause life-threatening blood dyscrasias (abnormal blood condition) 2. Aplastic anemia (bone marrow does not produce sufficient new blood cells) and Hypoplastic anemia (decreased RBCs) 3. Thrombocytopenia and granulocytopenia
92
What agent can cause gray baby syndrome?
Chloramphenicol
93
What are the components of prokaryotic ribosomes? (3)
1. 70S 2. Large subunit = 50S (5S, 23S) 3. Small subunit = 30S (16S)
94
What are two indications for rifaximin?
1. Traveler's diarrhea caused by E coli | 2. Hepatic encephalopathy
95
What are three examples of echinocandins?
1. Caspofungin 2. Micafungin 3. Andulafungin
96
When should caspofungin be dose adjusted?
Severe liver dysfunction
97
Are azole antifungals inducers or inhibitors of CYP?
Inhibitor
98
What is a cardiovascular ADR of azole antifungals?
QT prolongation

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