CHAP 5- Bone regeneration Flashcards

(50 cards)

1
Q

1rt years exodontia

A

Mandible 4-6 mm
Maxilla 2-4 mm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

After first years reabsorption

A

slow and progressive
more intense in the mandible tan in the maxillary bone
3/1 o 4/1
Manible : Arc widening
Maxilla : arc narrowing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Important Factors in Bone Regeneration

A

❖ Aesthetic and functional requirements of the patient
❖ Budget
❖ Tobacco
❖ Patient’s oral hygiene habits
❖ Availability of suitable donor sites ( in case of autologous grafting)
❖ Intraoral soft tissue status

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Autologous graft

A
  • Graft from the recipient’s own
  • Body Extraoral and intraoral donor
    sites
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Homologous graft
allograft
allogenic graft

A
  • Grafts from the same species
  • Mineralised freeze-dried bone/des
    (FDBA,DFDBA), fresh frozen
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Heterologous graft or Xenografts

A
  • Grafts from different species
  • Bovine bone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Alloplastic or synthetic graft

A
  • Laboratory synthesized inert material
  • Bioceramics (HA, B-TCP), Polymers, Bioactive Glasses
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Classification of Bone Grafts
BY ITS STRUCTURE
SPONGIOUS

A

+ o s t e o g e n i c c e l l s
- s t r u c t u r a l
s t i f f n e s s
+ r e s o r p t i o n
+ v a s c u l a r i z a t i o n

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CORTICAL

A
  • o s t e o g e n i c c e l l s
    + s t r u c t u r a l s t i f f n e s s
  • r e s o r p t i o n
    + o s t e o c o n d u c t i v e c a p a c i t y
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Particulated bone

A
  • Auto, Alo, Xeno,
  • Alloplastic
  • By itself, with plasma, with blood
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Composite

A

Mixed with each other

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Classification of Bone Grafts
BY Regeneration Mechanism
OSTEOGENESIS

A
  • It is the formation of bone tissue starting from living
    cells coming from the graft. ==> Autologous
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

OSTEOINDUCTION

A
  • It is a process by which mesenchymal cells in the
    recipient site a re-transformed into osteoforming cells .
  • This stimulus is provided by growth factors.
    ==>Autologous bone and Autograft
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

OSTEOCONDUCTION

A
  • It is a phenomenon in which the graft serves as a guide for bone neoformation .
  • It is colonized by blood vessels and osteoprogenitor cells of the recipient site .
  • As it is resorbed, it is replaced by neoformed bone tissue .
    ==>All of grafts
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Autologous dentin

A

❖ Studies with a larger sample size, and especially with a longer follow-up time, are needed to confirm the long-term stability of this material.
❖ Human dentin and bone tissue have a similar chemical composition.
❖ Autogenous dentin possesses osteoconduction and osteoinduction properties.
❖ Good results in terms of bone gain and consistency, and even better results compared to other materials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Gold standard

A

Autologous bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Autologous bone = PROS

A

❖ No additional biomaterial cost
❖ No immunological reaction
❖ Osteo-gene/inducer/conducer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Autologous bone = CONS

A

❖ Donor area (additional surgery)
❖ Increased morbidity (2 fields)
❖ Limited availability of intraoral grafts
❖ Extraoral grafts: AG, QX…
❖ High resorption rate
❖ Not storable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

DONOR SITES FOR AUTOGRAFTS

A
  • Cortical/spongious
  • Block/Particulated
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Intraoral regions

A

Intramembranous: less reabsorption
Mandibular ramus
Mandibular body
Mandibular symphysis
Tuberosity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Extraoral regions

A

Endocondral: more reabsorption
Iliac crest
Tibia
Fibula
Calotte

22
Q

objet for get bone

A

BONE SCRAPERS

23
Q

rotatory instrument

A

Harvesting burs
Biological harvesting slow velocity

24
Q

BONE SCRAPERS

25
P A R T I C U L A T E G R A F T S
ABSENCE OF STIFFNESS/MECHANICAL STRENGTH ===> SOFT TISSUE COLLAPSE OVER THE GRAFT + PARTICLE COMPRESSION ==> LOSS OF STABILITY + ACCELERATED RESORPTION
26
PA RT I C U L AT E G R A F T S IN CASES OF DEFECTS OF MORE THAN ONE WALL, IT IS NECESSARY TO USE
TITANIUM MEMBRANES OR MESHES THAT WILL KEEP THE GRAFT FREE OF TENSIONS.
27
GUIDED BONE REGENERATION
BIOLOGICAL PRINCIPLE THAT CONSISTS OF PREVENTING ACCESS TO THE AREA TO BE REGENERATED BY CELLS FROM THE CONNECTIVE TISSUE AND EPITHELIUM, ALLOWING COLONIZATION OF THE SPACE BY CELL LINES FROM THE BONE
28
WHAT IS MEMBRANE
ISOLATION BARRIER BETWEEN CONNECTIVE TISSUE AND THE BONE BED ==> TARGETED DIFFERENTIATION OF BONE TISSUE TO PROMOTE BONE REGENERATION
29
M E M B R A N A E S ==> P R O P E R T I E
Exclude gingival fibroblasts and epithelial cells from the regeneration zone Mechanical stability : provide a stable space and protect clot and graft biocompatible integrate with surrounding tissues Manageable Low cost
30
M E M B R A N A E S ==> USE
Extend 2 to 3 mm beyond the margins of the defect good adaptation Resorbable: hydrate before Correct stabilization
31
RESORBABLE MEMBRANES ==> NATURAL OR SYNTHETIC
Most used: Collagen tendons, , skin or pericardium / bovine or porcine They vary according to: type, structure, degree of cross-linking (cross-linked) and collagen treatment.
32
Resorb/Resorption
FAST : 2-4 mouths Medium : 4-mouths Slow: more than 6 mouths
33
resorb/Membranes Advantages
No 2nd surgery removed Easy adaptation and handling Good biocompatibility
34
resor/Membranes Iconvenient
Lack of stiffness Unpredictable degree of resorption If exposed rapid resorption
35
Non Resorbable membranes/Mesh ADVANTAGES
Dense surface to soft tissue. Avoids fibrous tissue in the bone defect
36
Non Resorbable membranes/Mesh Inconvenient
2nd surgery for removal More complicated management Higer rate of exposure (infection)
37
Resorbable membranes Indications
- L O C A L A L V E O L A R R I D G E D E F E C T S ( L I M I T E D H O R I Z O N T A L O R V E R T I C A L ) - P E R I - I M P L A N T B O N E R E G E N E R A T I O N - D E H I S C E N C E S A N D F E N E S T R A T I O N S A S S O C I A T E D W I T H I M P L A N T P L A C E M E N T - B O N E D E F E C T S A S S O C I A T E D W I T H O S S E O I N T E G R A T I O N F A I L U R E S - B O N E L E S I O N S - C O V E R A G E O F S I N U S M E M B R A N E P E R F O R A T I O N S I N S I N U S L I F T S
38
Non resorbable membranes / Mesh INDICATIONS
ALL (same as resorbable) More advantages but more difficult to work with and higher rate of complication incidence Large defects (longer time and bone maturation): Vertical and some horizontal regenerations
39
PARTICULATE GRAFTS OPTIMAL PARTICLE SIZE
0,25MM- 2 MM
40
CLINICAL USES OF PARTICULATE GRAFTS
(SOCKET PRESERVATION) FENESTRATIONS AND DEHISCENCES (GUIDED BONE REGENERATION) MAXILLARY SINUS ELEVATION PERI-IMPLANT DEFECTS
41
FENESTRATIONS AND DEHISCENCES
NARROW ALVEOLAR RIDGES OR BUCCAL CONCAVITIES DEHISCENCE(couvre pas jusqu'a l'apex): THE MOST CORONAL SPIRES ARE EXPOSED WITHOUT BONE COVERING. FENESTRATION(fenetre): LACK OF BONE COVERING OF THE IMPLANT IN ITS APICAL PORTION.
42
GUIDED BONE REGENERATION
Tinti’s Technique Vertical augmentation with immediate IOI placement
43
GUIDED BONE REGENERATION URBAN TECHNIQUE SAUSAGE TECHNIQUE (VERTICAL/HORIZONTAL AUGMENTATION)
- MIXTURE 1:1 : AUTOLOGOUS H. AND XENOGRAFT - SLOWLY RESORBABLE MEMBRANE OF COLLAGEN FIXED WITH PINS. - WAIT 8-9 MONTHS FOR IOI
44
PASS Principe for predictable bone regeneration
Primary wound closure Angiogenesis Space creation/maintenance Stability of initial blood clot and implant fixture
45
BLOCK GRAFTS Sequence of block grafts
- Preparation of the recipient area - Graft harvesting (in case of intraoral: chin, branch, tuberosity) - Adaptation + fixation of the block - Soft tissue coverage of the recipient site - Closing of donor area - Re-entry
46
Instruments for graft harvesting
- Crack milling cutter - Oscillating saw - Discs - Trephines - Piezoelectric
47
CLINICAL USES OF BLOCK GRAFTS Khoury’s technique Vertical and horizontal regeneration
- Procurement of autogenous block graft from retromolar area and split into two thin cortical lamellae. - In the recipient area, the sheets are arranged in a box shape with micro-screws. - Subsequently, the space is filled with autologous particulate bone. - Waiting 4 months and placement of IOI - In 2nd phase soft tissue augmentation
48
Complications Intraoperative
- Hemorrhage - Injury to vascular-nerve structures - Bone fractures
49
Post-operative
Suture dehiscence and wound opening Membrane and graft exposure Infection
50
Complications Resorption
❖ Bone grafts in apposition: high rate of resorption in the short and medium term ❖ Resorption rates during the first 6 months of 11-41.5%. ❖ If the graft is not subjected to mechanical stimulation: 92% resorption rate. ❖ Intramembranous bone resorbs less and revascularizes faster than grafts of endochondral origin