Chap6:2 O2 bound to hemoglobin

Question 1

oxyhemoglobin

Answer 1

the product of combining hemoglobin with oxygen. The loosely bound complex dissociates easily when the concentration of oxygen is low.

Question 2

reduced hemoglobin

Answer 2

Hemoglobin not bound with oxygen. Also called deoxyhemoglobin

Question 3

deoxyhemoglobin

Answer 3

Hemoglobin not bound with oxygen. Also called reduced hemoglobin

Question 4

each RBC contains how many hemoglobin molecules

Answer 4

about 280

Question 5

Normal adult Hb (Hb A) consists of

Answer 5

4 heme groups (iron, pigmented, nonprotein portion of the Hb)
4 amino acid chains: 2 alpha and 2 beta (make protein globin)

Question 6

oxygen content

Answer 6

is the sum of the oxygen attached to hemoglobin plus that dissolved in plasma

Question 7

factory that alter o2 content

Answer 7

• anything affecting Hb or saturation of Hb (will have a dramatic effect)
• Po2 has a minimal effect on o2 content, but is a major determinate of saturation of hemoglobin

Question 8

how many O2 molecules can bind with Hb

Answer 8

4, one for each heme/iron group

Question 9

the amount of oxygen bound to Hb is directly related to

Answer 9

the partial pressure of oxygen

Question 10

the alpha chain of the Hb molecule has ___ amino acids

Answer 10

141 each

Question 11

the beta chain of the Hb molecule has ___ amino acids

Answer 11

146 each

Question 12

why does fetal hemoglobin have a stronger attraction to O2

Answer 12

it has to gamma strands instead of beta. it helps to transfer maternal o2 across the placenta. Hb F turns to Hb A by first year of life

Question 13

methemoglobin

Answer 13

• changing the iron molecules from ferrous state to ferric state, eliminating the ability of hemoglobin to transport o2
• causes; drugs, chemicals (nitrites)

Question 14

what happens is the precise number, sequence, or spatial arrangement of the globin amino acid chains is altered?

Answer 14

the hemoglobin will be abnormal i.e. sickle cell hemoglobin (Hb S)

Question 15

normal hemoglobin value for adult males

Answer 15

14-16 g/100 mL of blood

Question 16

how many Heme groups are there in Hb

Answer 16

4

Question 17

g%/Hb or g%/dL

Answer 17

grams percent of hemoglobin or grams per deciliter. g% represents the weight

Question 18

average adult female hemoglobin value is

Answer 18

12-15 g%

Question 19

average intent hemoglobin value is

Answer 19

14-20 g%

Question 20

what percent of the RBC weight is Hb roughly

Answer 20

33%

Question 21

each g% of Hb can carry___mL of O2

Answer 21

1.34 mL of oxygen

Question 22

if a Hb is 15g%, and if fully saturated, about ____vol% of O2 will be bound to the Hb

Answer 22

O2 bound to Hb = 1.34 mL O2(15 g% Hb)

20.1

Question 23

O2 content of arterial blood

Answer 23

CaO2=(Hb X 1.34 X SaO2) + (PaO2 x 0.003)

Question 24

Mixed venous blood is drawn from

Answer 24

The pulmonary artery

Question 25

O2 bound to Hb=

Answer 25

1.34(g%Hb)SaO2

Question 26

at normal Pao2 of 100 torr, however, the SaO2 is about 97%. why?

Answer 26

physiologic shunts: - thebesian venous drainage into the left atrium - bronchial venous drainage into the pulmonary veins - alveoli that are under ventilated relative to pulmonary blood flow