Flashcards in Chapter 03: Erectile Dysfunction Deck (14):
What is a disorder that is due to depression, anxiety and pyschological stress?
What is the four types Organic causes of ED
What is the brand name for the following drugs:
Where is smooth muscle NOT loacted:
A. Blood vessels
E. Walls of hollow organs in digestive, reproductive and urinary tracts
An increase in ___________ leads to binding of ______ to _____ and ______cycling resulting in muscle_______
C.C; M; A; CB; C
The regulatory light chain is phosphorlyated by _________
MLCK (Myosin light chain kinase)
What activates MLCK?
Calmodulin Ca++ complex
When cytoplasmic Ca++ is (high/low), Ca++ forms a complex with calmodulin which (activates/deactivates) MLCK, which causes smooth muscle (contraction/relaxation). When cytoplasmic Ca++ is. (High/Low), myosin phosphotase (phosphorylates/dephoshphorylates) regulatory light chain which causes smooth muscle (contraction/relaxation)
High; activates; contraction
Low; dephoshorylates; relaxation
PDE5 block _____ of____ to_______and lead to lowered cytoplasmic Ca++ and lead to relaxation
Hydrolysis; cGMP to 5’-GMP
PD5E afftects which tissues?
Corpus cavernosum, vascular smooth muscle and platelets
Why are nitrates bad for people taking PDE5 inhibitors?
Nitrates are vasodialators and can lead to servere drop in blood pressure
What is priapsim and what treatments can be done for men who have it?
Priapism is a condition where erection becomes very painful and persistent (prolonged erection).
Treatments include injection of phenylephrine into the smooth muscle or surgical drainage
Where must the Alprostadil be injected into if not inseting it into the urethra and why must you not exceed the maximum dosage (3x per week)?
Into the corpus cavernosa (chemical response more than neural)
Too many dosages can cause peyronie’s disease