chapter 1 Flashcards
Define Drug
any chemical that alters an organisms functions or processes
Define pharmacoology
the study of drugs (origin, properties, and interacting)
Define Pharmacy
preparation and dispensing of drugs
Define therapeutics
art of treating disease with drugs
Define toxicology
study of toxic substances an their pharmacological actions, including antidotes and poison control
Define pharmacognosy
identification of sources of drugs
Today the most common source of drugs is?
chemical synthesis but plant, animals, and minerals have often contributed the prototype of the active ingredient
Naturally occurring drugs date back to when?
Egyptian papyrus records, to the ancient Chinese and Central American civilizations and is still seen in remote regions of modern America, such as Appalachia.
Animal is a source of drug, name what is under its classification.
- thyroid hormone
- insulin
- pancreatic domase
plant is a source of drugs, name what is under its classification.
- khellin (ammi visnaga)
- Atropine (belladonna alkaloid)
- Digitalis (fox glove)
Mineral is a source of drugs, name what is in its classification.
- Copper sulfate
- magnesium sulfate
- mineral oil
Drug approval in the US is long, costly, and complex. In thee 1980’s it took 13-15 years and 350 million dollars (chemical trials to FDA approval. A more recent study showed?
900 million dollar in today’s market (research, development, pre and post clinical trials)
There is how many phases in drug approval?
3 phases
Define Mutagenicity
mutation in the gene
Define Teratogenicity.
Changes in the developing embryo
Define Carcinogenicity
increase risk of cancer
What is phase 1?
Investigated in small groups of individuals with the disease the drug is intended to treat
What is phase 2?
Investigated as a treatment for a small number of individuals with the disease the drug is intended to treat
What is phase 3?
investigated in large, multi center studies to establish safety and efficacy
Naming drugs: What is the Chemical name?
The name indicating the drug’s chemical structure
Naming drugs: What is the code name?
A name assigned by a manufacturer to an experimental chemical that shows potential as a drug
-numerical or alphanumerical
Naming Drugs: what is the generic name (aka nonproprietary)?
name assigned by the United States adopted name (USAN) Council when a chemical appears to have therapeutic uses and the manufacturer wishes to market the drug
-name i base loosely on the chemical structure of the drug
Naming drugs: What is the official name?
in the event an experimental drug becomes fully approved for general use, the generic name becomes its official name.
Naming drugs: What does the Trade Name (aka proprietary nme) mean?
brand name given by a particular manufacturer