Chapter 1 rounds Flashcards Preview

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Flashcards in Chapter 1 rounds Deck (17):
1

DICER

DICER trims and processes primary microRNA

2

RISC

RNA induced silencing complex: multiprotein aggregate assocaites with mature ss microRNA to target mRNA for cleavage and repress translation

3

XIST

Long noncoding RNA transcribed from x chromsome: essential in physiologic X chromosome inactivation: gene silencing

4

Phosphatidylserine

Inner leaflet of cell membrane, when flipped to extracellular surface cell undergoes apoptosis.

5

Endocytosis mechanisms

1. Caveolae: plasma membrane invaginations (potocytosis)
2.Clathrin: receptor mediated endocytosis (pinocytosis)

6

List intermediate filaments (6)

Lamin A, B, C
Vimentin
Desmin
Neurofilaments
Flial fibrillary acidic protein
Cyotkeratins

7

Occluding junction examples (4)

Complexes composed of transmembrane proteins:
Claudin, occludin, zonulin, catenin

8

Spot desmosomes function and examples

Macula adherens
Desmoglein and desmocolin (cadherins): linked to intracellualr intermediate filaments allow forces to be communicated over multiple cells

9

The warburg effect

upregulate glucose and glutamine cell uptake and decreased ATP per glucose molcule.

10

Second messenger examples (7)

Calcium
cAMP
cGMP
inositol triphosphate
Diacylglycerol
arachodonic acid
nitric oxide

11

TGF beta family proteins (4)

bone morphogenic proteins
activins
inhibins
mullerian inhibiting substances

12

basement membrane composition

Collagen 4 and laminin:

13

Fibrillar collagens (4)

type 1,2,3,5

14

Fibrillar collagen defects examples (2)

1. osteogenesis imperfecta
2. Ehlers danlos syndrome

15

Adhesive glycoproteins (3)

1. fibronectin
2. laminin
3. integrins

16

Most important checkpoint for DNA integrity before irreversible replication

G1-S checkpoint

17

Check point that ensures accurate genetic replication

S-G2 checkpoint